The Role of Prostaglandins in the Regulation of Blood Pressure with Special Reference to Vascular Reactivity : SYMPOSIUM ON BLOOD PRESSURE AND VASOACTIVE SUBSTANCES

スポンサーリンク

概要

• 論文の詳細を見る

• The role of prostaglandins (PGs) in the regulation of blood pressure was analysed from the point of view of vascular reactivity to PGs and also of PG-induced modulation of pressor response. The vasodepressor effect of PGE_1 as more sensitive in the patients with essential hypertension than in the normotensive subjects. In the normotensive subjects or in rats, pressor response to norepinephrine was modulated by PGE_1, enhanced under treatment with indomethacin, an inhibitor of PG biosynthesis, and suppressed under an infusion of PGE_1. These results indicate that pressor response to norepinephrine is modulated by exogenous and endogenous PGs. The PG-induced modulation disappeared after chemical sympathectomy, suggesting that the PG-induced modulation of pressor response is regulated by the sympathetic nervous system. In sympathetic neurotransmission, PGs could play an important role in the regulation of norepinephrine release. Renal content of norepinephrine was reduced under treatment with indomethacin, indicating an enhanced release of norepinephrine and an enhanced turnover of norepinephirne in the kidneys under treatment with indomethacin. These results suggest that a deficient state of PG may enhance the pressor response and norepinephrine release. As there is much evidence indicating that the reduction of PG synthesis in patients and animals with hypertension, vascular reactivity to PGs and PG-induced modulation of pressor response may play significant roles in the regulation of blood pressure and could be causal factors of hypertension.

• 社団法人日本循環器学会の論文
• 1984-02-20

著者

• Okajima Hiroshi

  Department Of Anatomy Kyoto Prefectural University Of Medicine

• IJICHI Hamao

  Second Department of Internal Medicine, Kyoto Prefectural University of Medicine

• Yoshimura Manabu

  Department Of Clinical Laboratory And Medicine Kyoto Prefectural University Of Medicine

• Yoshimura Manabu

  Department Of Clinical And Laboratory Medicine Kyoto Prefectural University Of Medicine

• Ijichi H

  2nd Department Of Medicine Kyoto Prefectural University Of Medicine

• Ijichi Hamao

  Second Department Of Medicine Kyoto Prefectural University Of Medicine

• Takeda K

  Kyoto Industrial Health Association

• SASAKI Susumu

  Second Department of Internal Medicine. Kyoto Prefectural University of Medicine

• TAKEDA Kazuo

  Second Department of Internal Medicine. Kyoto Prefectural University of Medicine

• YOSHIMURA Manabu

  Second Department of Internal Medicine. Kyoto Prefectural University of Medicine

• OKAJIMA HIROSHI

  Second Department of Medicine, Kyoto Prefectural University of Medicine

• TAKAHASHI HAKUO

  Second Department of Medicine, Kyoto Prefectural University of Medicine

• Sasaki Susumu

  Department Of Medicine Akashi City Hospital

• Takahashi Hakuo

  The Second Department Of Medicine Kyoto Prefectural University Of Medicine

• SHIKUMA RIEKO

  Second Department of Internal Medicine Kyoto Prefectural University of Medicine

• TAKASHINA RYOSAKU

  Second Department of Internal Medicine Kyoto Prefectural University of Medicine

• YAMAZAKI HIDEAKI

  Second Department of Internal Medicine Kyoto Prefectural University of Medicine

• Okabayashi Hideoki

  2nd Department Of Medicine Kyoto Prefectural University Of Medicine

• Okamura H

  Department Of Anatomy Kyoto Prefectural University Of Medicine

• Okamura Hiro-oki

  Department Of Audio-vestibular Neuroscience Tokyo Medical And Dental University

• Yoshimura Manabu

  The Second Department Of Medicine Kyoto Prefectural University Of Medicine

• Yamasaki Hideaki

  The Second Department Of Internal Medicine Kyoto Prefectural University Of Medicine

• Yoshimura Manabu

  Department Of Clinical Laboratory And Medicine And The Third Department Of Internal Medicine Kyoto P

• Takashina R

  Second Department Of Internal Medicine Kyoto Prefectural University Of Medicine

• Sasaki Susumu

  Division Of Hypertension And Nephrology Department Of Medicine Kyoto Prefectural University School O

• Sasaki Susumu

  Second Department Of Internal Medicine Kyoto Prefectural University Of Medicine

• Okamura Hiro-oki

  Department Of Otolaryngology Tokyo Medical And Dental University

• Ijichi Hamao

  Second Department Of Internal Medicine Kyoto Prefectural University Of Medicine

• YOSHIMURA MANABU

  Second Department of Internal Medicine Kyoto Prefectural University of Medicine Kyoto

• TAKAHASHI Hakuo

  Second Department of Internal Medicine, Kyoto Prefectural University of Medicine

• TAKEDA Kazuo

  Second Department of Internal Medicine, Kyoto Prefectural University of Medicine

• Okajima Hiroshi

  Second Department of Internal Medicine, Kyoto Prefectural University of Medicine

関連論文

• DNA Cytofluorometry of Leukemic Cells identified by Wright-Giemsa Stain; Study on Destaining Method
• Association of Human Hepatocyte Growth Factor with Hemodialysis Hypotension
• Restriction of Dietary Sodium May Enhance Nitric Oxide Production in Rats
• Mechanism of Hypertension Induced by Chronic Inhibition of Nitric Oxide in Rats
• -0642- Angiotensin II inhibits L-type Ca current in pacemaker cells isolated from the rabbit sinoatrial node(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
• Urinary Excretion of Free Dopamine and Digoxinlike Substances Correlates with Endogenous Secretion of Insulin in Normotensive Adults, but Not in Hypertensive Subjects
• Does Dopamine Act on Myocardial Cells?
• Diagnostic Significance of Dopamine Estimation Using Plasma and Urine in Patients with Adrenal and Renal Insufficiency, Renal Transplantation and Hypertension
• -0338- CHANGES IN DIETARY SALT INTAKE MAY PLAY A ROLE IN THE REGULATION OF RENIN GENE EXPRESSION IN THE HYPOTHALAMUS OF RATS(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
• AN ATP-SENSITIVE K^+ CHANNEL IN THE BRAIN PLAYS A ROLE IN ARTERIAL PRESSURE REGULATION DURING ACUTE CEREBRAL ISCHEMIA
• BETA-3 ADRENERGIC AGONIST, BRL-26830A, AND ALPHA/BETA BLOCKER, AROTINOLOL, MARKEDLY INCREASE REGIONAL BLOOD FLOW IN THE BROWN ADIPOSE TISSUE IN ANESTHETIZED RATS
• NICORANDIL (2-NICOTINAMIDOETHYL NITRATE) INHIBITS BOTH VASO-DILATING AND -CONSTRICTING EFFECTS OF ENDOTHELIN IN A VASCULARLY ISOLATED HIND-LIMB PREPARATION IN RATS
• INTRACEREBROVENTRICULAR INJECTIONS OF ENDOTHELIN INCREASE ARTERIAL PRESSURE IN CONSCIOUS RATS : The 53th Annual Scientific Session of the Japanese Circulation Society
• MEASUREMENT OF DIGITAL ARTERIAL PRESSURE IN PATIENTS WITH ESSENTIAL HYPERTENSION
• -P115-THE EFFECTS OF ENDOTHELIN ON CENTRAL REGULATION OF ARTERIAL PRESSURE : INTRACEREBROVENTRICULAR INJECTION OF ENDOTHELIN IN RATS : Hypertension : FREE COMMUNICATIONS(III) : PROCEEDINGS OF THE 53th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION
• Pathophysiological Role of Dopamine on the Development of Hypertension in Rats
• Evidence for a Digitalis-Like Substance in the Hypothalamopituitary Axis in Rats : Implications in the Central Cardiovascular Regulation Associated with an Excess Intake of Sodium
• -491- A LINK BETWEEN THE CENTRAL CARDIOVASCULAR CONTROL AND THE THERMOREGULATION IN SHR : INVOLVEMENT OF BRAIN ANGIOTENSIN II
• -344- INHIBITORY ROLES OF THE HYPOTHALAMIC ATRIAL NATRIURETIC POLYPEPTIDE ON THE VASOPRESSIN RELEASE IN THE SODIUM-LOADED RATS
• HYPOTENSIVE RESPONSES TO CENTRALLY ADMINISTERED TAURINE IN DOCA-SALT HYPERTENSIVE AND SPONTANEOUSLY HYPERTENSIVE RATS
• Hypotension and Hypothalamic Depression Produced by Intracerebroventricular Injections of GABA in Spontaneously Hypertensive Rats : THE 15th CONFERENCE ON THE PATHOGENESIS OF HYPERTENSION
• Salt Elevates Blood Pressure with Biphasic Changes in Hypothalamic Responsiveness : THE 15th CONFERENCE ON THE PATHOGENESIS OF HYPERTENSION
• ATTENUATED DEVELOPMENT OF HYPERTENSION BY CHRONIC ADMINISTRATION OF BROMOCRIPTINE IN DOCA-SALT HYPERTENSIVE RATS
• ENHANCED RENAL SYMPATHETIC NERVE ACTIVITY IN RESPONSE TO SALT LOADING IN RATS
• CENTRALLY INDUCED VASODEPRESSOR AND SYMPATHETIC NERVE RESPONSES TO TAURINE
• Peripheral Origin of Plasma Dopamine : THE 14th CONFERENCE ON THE PATHOGENESIS OF HYPERTENSION
• Renal Denervation Inhibits Hypothalamo-Sympathetic Nerve System in Normotensive and Hypertensive Rats : THE 14th CONFERENCE ON THE PATHOGENESIS OF HYPERTENSION
• ACTIVITIES OF HYPOTHALAMO-SYMPATHETIC NERVOUS SYSTEM DURING DEVELOPING STAGES OF SODIUM-INDUCED HYPERTENSION : Hypertension (II) : FREE COMMUNICATIONS (II) : PROCEEDINGS OF THE 49th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• Chronic Angiotensin Blockade with Candesartan Cilexetil in DOCA/Salt Hypertensive Rats Reduces Cardiac Hypertrophy and Coronary Resistance without Affecting Blood Pressure
• -1120- ROLE OF NITRIC OXIDE IN IMPAIRED CORONARY CIRCULATION AND IMPROVEMENT BY ANGIOTENSIN RECEPTOR ANTAGONIST IN HYPERTENSIVE HEART(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
• -1045- The Role of Impaired Glucose Tolerance and Hyperinsulinemia on the Development of Hypertension in Sucrose-fed SHR(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
• Low Frequency Regular Exercise Improves Flow-Mediated Dilatation of Subjects with Mild Hypertension
• Lowering of Blood Pressure Improves Endothelial Dysfunction by Increase of Nitric Oxide Produciton in Hypertensive Rats
• Role of the Central Nervous System in the Development of Hypertension Produced by Chronic Nitric Oxide Blockade in Rats
• P342 ROLE OF NITRIC OXIDE AND EFFECT OF L-ARGININE IN IMPAIRED CORONARY CIRCULATION OF HYPERTENSIVE HEART
• ROLE OF SYMPATHETIC NERVE INHIBITION IN THE VASODEPRESSOR EFFECT OF BROMOCRIPTINE IN NORMOTENSIVE AND HYPERTENSIVE RATS
• CENTRAL DEPRESSOR MECHANISMS OF CALCIUM IN NORMOTENSIVE AND HYPERTENSIVE RATST : Hypertension : 53 Annual Scientific Meeting, Japanese Circulation Society
• CENTRAL BAROREFLEX REGULATION BY THE RENAL NERVES IN ANESTHETIZED RATS
• -480- EFFECTS OF SINOAROTIC DENRVATION (SAD) ON THE DEVELOPMENT OF HYPERTENSION AND HYPOTHALAMO-SYMPATHETIC NERVOUS SYSTEM IN DOCA-SALT TREATED RATS
• CENTRALLY INHIBITORY EFFECT OF ADRENALLINE ON CARDIOVASCULAR AND SYMPATHETIC NERVE SYSTEM IN URETHANE ANESTHETIZED RAT
• KCl Inhibits Hypothalamic Activity to Attenuate Hypertension in DOCA-salt Rats : THE 13TH CONFERENCE ON THE PATHOGENESIS OF HYPERTENSION
• Centrally-Induced Vasopressor Responses to Sodium-Potassium Adenosine Triphosphatase Inhibitor, Ouabain, may be Mediated Via Angiotensin II in the Anteroventral Third Ventricle in the Brain : THE 13TH CONFERENCE ON THE PATHOGENESIS OF HYPERTENSION
• EFFECT OF BROMOCRIPTINE ON BLOOD PRESSURE AND PRESSURE RESPONSE TO EXERCISE IN PATIENTS WITH ESSENTIAL HYPERTENSION : Hypertension(I) : I : 48 Annual Scientific Meeting, Japanese Circulation Society
• RETARDATION OF THE DEVELOPMENT OF HYPERTENSION IN DOCA-SALT RATS BY RENAL DENERVATION
• The Role of Prostaglandins in the Regulation of Blood Pressure with Special Reference to Vascular Reactivity : SYMPOSIUM ON BLOOD PRESSURE AND VASOACTIVE SUBSTANCES
• CENTRALLY INDUCED VASOPRESSOR AND SYMPATHETIC NERVE RESPONSES TO CARBACHOL IN RATS
• CENTRALLY-INDUCED VASOPRESSOR RESPONSES TO OUABAIN ARE AUGMENTED IN SPONTANEOUSLY HYPERTENSIVE RATS : PROCEEDINGS OF THE 47th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY : Hypertension
• HETEROGENEITY OF VASODEPRESSOR RESPONSES BY CAPTOPRIL : Hypertension (I) : 46th Annual Scientific Meeting, Japanese Circulation Society
• Assessment of Vascular Damage by Pulse Wave Velocity and Photoplethysmogram in Hypertensive Subjects
• ENDOGENOUS BRAIN ANGIOTENSIN II-MEDIATED SYMPATHETIC NERVE RESPONSES ARE NOT AUGMENTED IN MATURE SPONTANEOUSLY HYPERTENSIVE RATS
• Effects of Angiotensin II Type 1 Receptor Antagonist on Pressor Responses to Pulsatile Compression of the Rostral Ventrolateral Medulla in Rats
• Increased Blood Pressure, Drinking, and Salt Preference by Neuron-Specific Expression of Human Renin
• Effects of Pravastatin on Exercise Electrocardiography Test Performance and Cardiovascular Mortality and Morbidity in Patients With Hypercholesterolemia : Lipid Intervention Study in Kyoto
• -105- HIGH FIBRINOPEPTIDE A (FPA) LEVELS IN ATRIAL FIBRILLATION AND THE EFFECTS OF HEPARIN ADMINISTRATION : Pulmonary Circulation, Papillary Circulation : FREE COMMUNICATIONS(I) : PROCEEDINGS OF THE 51th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATI
• IMPLICATION OF Na^+,Ca^ OR Na^+-K^+ ATPase ON PGI_2 GENERATION IN CULTURED HUMAN VASCULAR ENDOTHELIAL CELLS : Pathophysiology, Vessel : PROCEEDINGS OF THE 50th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• PROSTACYCLIN GENERATION BY CULTURED HUMAN VASCULAR ENDOTHELIAL CELLS WITH REFERENCE TO ANGIOTENSIN I-CONVERTING ENZYME
• Tyrosine Hydroxylase and NADPH-Diaphorase in the Rat Nodose Ganglion : Colocalization and Central Projection
• Augmentation of Pulse Wave Velocity Precedes Vascular Structural Changes of the Aorta in Rats Treated with N^ω-Nitro-L-Arginine Methyl Ester
• OJ-110 The Efficacy of Educational Admission Program for Chronic Kidney Disease(Kidney/Renal circulation-1 (H) OJ19,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
• Contrasting Effects of Angiotensin Type 1 and 2 Receptors on Nitric Oxide Release under Pressure
• Effects of AT1 antagonist on pressor responses to pulsatile compression of the rostral ventrolateral medulla
• Association of Pressure Induced Hypertension with Specific Area of Ventrolateral Surface of Medulla Oblongata and Catecholamine Neurons
• 1079 THE ROLE OF HYPOTHALAMIC NITRIC OXIDE IN THE CARDIO-VASCULAR CONTROL DURING SHAKER STRESS IN AWARE RATS.
• OJ-013 HMG-CoA Reductase Inhibitors Upregulate Anti-aging Klotho mRNA via RhoA Inactivation(Neurohumoral Factors 1 (H) : OJ2)(Oral Presentation (Japanese))
• CENTRALLY-INDUCED VASOPRESSOR AND SYMPATHETIC NERVE RESPONSES TO INTRACEREBROVENTRICULAR OR INTRAHYPOTHALAMIC INJECTIONS OF OUABAIN IN THE DOCA-SALT HYPERTENSIVE RAT : Hypertension (II) : FREE COMMUNICATIONS (II) : PROCEEDINGS OF THE 49th ANNUAL SCIENTIFI
• ENDOGENOUS BRAIN ANGIOTENSIN II-MEDIATED SYMPATHETIC NERVE RESPONSES ARE NOT AUGMENTED IN MATURE SPONTANEOUSLY HYPERTENSIVE RATS : Hypertension (I) : 46th Annual Scientific Meeting, Japanese Circulation Society
• CENTRAL CHOLINERGIC VASOPRESSOR MECHANISMS IN SPONTANEOUSLY HYPERTENSIVE RATS : Hypertension (I) : 46th Annual Scientific Meeting, Japanese Circulation Society
• The Role of Brain Angiotensin II in the Mechanism of the Pressor Responses to Intracisternal Injection of Hypertonic NaCl in Urethane Anesthetized Rats : THE 11th CONFERENCE ON THE PATHOGENESIS OF HYPERTENSION
• THALLIUM-201 MYOCARDIAL IMAGING FOR EVALUATION OF LEFT VENTRICULAR HYPERTROPHY AND DILATATION: COMPARISON WITH ECHOCARDIOGRAPHY : Nuclear Cardiology : PROCEEDINGS OF THE 44th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• LEFT VENTRICULAR MID-WALL CIRCUMFERENTIAL FIBER SHORTENING WORK CALCULATED WITH THE SIMULTANEOUS RECORDING OF LEFT VENTRICULAR ECHOGRAM AND PRESSURE : IInd Auditorium
• Neuropeptide Y- and Met-Enkephalin-Arg^6-Gly^7-Leu^8-like Immunoreactive Neurons in the Locus Coeruleus in Prehypertension Stage of SHR
• Distribution and fine structure of [Met]-enkephalin-Arg^6-Gly^7-Leu^8-like immunoreactive neurons in the rat cerebellum
• Galanin Immunoreactive Fibers and Terminals in the Rat Medulla Oblongata and Spinal Cord
• COMBINED TECHNIQUES OF IMMUNOCYTOCHEMISTRY AND [^3H]THYMIDINE AUTORADIOGRAPHY FOR ANALYZING THE TIME COURSE OF PEPTIDE NEURON PRODUCTION (Contribution of Histochemistry to Developmental Neurobiology)
• Immunohistochemical Investigation of Nerve Fibers among the Cochlear Supporting Cells with the Combination of Antigen Retrieval and Signal Amplification Method
• P3-34 The presence of nerve fibers among the cochlear supporting cells by using combination of antigen retrieving and signal amplification method
• ENZYME CYTOCHEMICAL AND MORPHOMETRICAL ANALYSES OF GAP JUNCTIONS IN RABBIT OVARIAN GRANULOSA CELLS DURING FOLLICLE MATURATION AND OVULATORY PROCESS
• CYTOCHEMICAL LOCALIZATION OF ACID PHOSPHATASE IN THE RABBIT OVARIAN FOLLICLE
• Effect of Sodium Loading and Depletion on Vascular Reactivity and Prostacyclin Generation : IX Conference on the Pathogenesis of Hypertension
• Amplification of HLA-DQA1 gene from bloodstains by polymerase chain reaction.
• STUDIES ON β-PYRIDYLCARBINOL AS A PRECURSOR OF NICOTINAMIDE ADENINE DINUCLEOTIDE
• Enhanced Vascular Reactivity to Norepinephrine in Salt-Sensitive Patients with Hypertension
• Sympathetic and Pressor Hyperresponsiveness to Intracisternal Injections of Hypertonic NaCl in DOCA Hypertensive Rats : THE 10th CONFERENCE ON THE PATHOGENESIS OF HYPERTENSION
• CENTRALLY-INDUCED VASOPRESSOR RESPONSES TO CONJUGATED ESTROGENS : Kidney・Hypertension : FREE COMMUNICATIONS (Abstract) : 45 Annual Scientific Meeting, Japanese Circulation Society
• HMG-CoA Reductase Inhibitors Stimulate the Anti-Aging Klotho Protein Expression in Rats of Chronic NOS Inhibition
• An Assay for Antibodies to Thyroid Plasma Membrane Using the Isotope-labeled Protein A
• Clinical Study on Increased Serum Thyroxine-Binding Globulin in Cancerous State
• Urinary Excretion of LATS in a Patient with Gravesdisease Complicated by Nephrotic Syndrome
• Effect of Biogenic Amines on TRH-TSH System
• Immunohistochemical Localization of PhospholipaseA in the Guinea Pig Nasal Mucosa
• P3-22 The expression of 5-lipoxygenase in the guinea pig nose
• P3-20 Immunohistochemical localization of phospholipase A2 in the guinea pig nose
• An Attempt to Analyze Various Thyroid Stimulators by the Receptor Assay using hTSH Radioimmunoassay
• Changes in the Cyclic Nucleotides of Rat Thyroid, Pituitary and Plasma Caused by Methylthiouracil Treatment
• Effect of LATS, TSH and Cholera Toxin on the Thyroid Gland in Nude Mice
• The Role of Hypothalamo-sympathetic Nerve System to Maintain High Blood Pressure in DOCA Hypertensive Rats : IX Conference on the Pathogenesis of Hypertension
• Effect of sodium loading and depletion on cyclic nucleotides in plasma and aorta. Interaction between prostacyclin and cyclic nucleotides.
• The Study of the Third Heart Sound in Relation to the Left Ventricular Filling and Wall Movement by Echocardiography
• Defect of Dopaminergic Sodium-handling in SHR Kidneys
• The Effect of Propranolol on Blood Pressure and Sympathetic Nerve Activity in the Spontaneously Hypertensive Rats

もっと見る 閉じる

スポンサーリンク