Effect of LATS, TSH and Cholera Toxin on the Thyroid Gland in Nude Mice

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概要

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• Three thyroid stimulators; LATS, TSH, and cholera toxin, have been tested by bioassay using congenitally athymic homozygous mice (nu/nu), nude mice and control littermates (nu/+) possessing normal thymic function. nu/+ Animals showed a response to LATS similarly to normal white mice of the ddN strain. The assay response to LATS in nu/nu animals was about half that in normal mice. TSH also showed a less stimulating action in nude mice.<BR>Cholera toxin made a long acting response similarly to LATS. The response to cholera toxin in nude mice was about half that of normal control mice.<BR>The thyroid of nude mice has a receptor for LATS-immunoglobulin, TSH or cholera toxin, which is similar to that of normal mice.

• 社団法人 日本内分泌学会の論文

著者

• YOSHIMURA Manabu

  Second Department of Internal Medicine. Kyoto Prefectural University of Medicine

• HACHIYA TAKASHI

  Second Department of Surgery, Hamamatsu University School of Medicine

• KAJITA YOSHIHIRO

  Second Department of Internal Medicine, Kyoto Prefectural University of Medicine

• Ochi Y

  Research Institute For Production Development

• MIYAZAKI TADAYOSHI

  Second Department of Internal Medicine Kyoto Prefectural University of Medicine Kyoto

• OCHI YUKIO

  Second Department of Internal Medicine Shiga University of Medical Science

• YOSHIMURA MANABU

  Second Department of Internal Medicine Kyoto Prefectural University of Medicine Kyoto

• KAJITA YOSHIHIRO

  Second Department of Internal Medicine Kyoto Prefectural University of Medicine Kyoto

• HACHIYA TAKASHI

  Second Department of Internal Medicine Kyoto Prefectural University of Medicine Kyoto

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