Clinical Study on Increased Serum Thyroxine-Binding Globulin in Cancerous State

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概要

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• Serum thyroxine-binding globulin (TBG) in 169 patients with various cancers was determined by radioimmunoassay (RIA). Eleven patients showed a high serum TBG level (>35μg/m<I>l</I>). Two of them had been treated with estrogen for prostate cancer. One patient had high serum TBG with serum hepatitis. Another 8 cases had normal liver function and also normal levels serum estrogen. Thus, about 4.7%(8/169) of the cancer patients had high serum TBG and mild hyperthyroxinemia caused by unknown mechanisms.<BR>The high TBG level in these patients continued until just before death, or in some cases decreased to nomal after removal of cancer tumors by operation.<BR>Caner is occasionally associated with an increase in serum TBG. Although the mechanism is not clear, the increased TBG in the cancerous state is interesting and has significance as a tumor marker.

• 社団法人 日本内分泌学会の論文

著者

• IJICHI Hamao

  Second Department of Internal Medicine, Kyoto Prefectural University of Medicine

• YOSHIMURA Manabu

  Second Department of Internal Medicine. Kyoto Prefectural University of Medicine

• KAJITA Yoshihiro

  Department of Medicine, Nantan General Hospital

• KAJITA YOSHIHIRO

  Nantan General Hospital

• HACHIYA TAKASHI

  Second Department of Surgery, Hamamatsu University School of Medicine

• MIYAZAKI TADAYOSHI

  Second Department of Internal Medicine Kyoto Prefectural University of Medicine Kyoto

• OCHI YUKIO

  Second Department of Internal Medicine Shiga University of Medical Science

• ISHIDA MASAO

  Department of Internal Medicine Nantan General Hospital

• Ijichi Hamao

  Second Department Of Internal Medicine Kyoto Prefectural University Of Medicine

• YOSHIMURA MANABU

  Second Department of Internal Medicine Kyoto Prefectural University of Medicine Kyoto

• KAJITA YOSHIHIRO

  Department of Internal Medicine Nantan General Hospital

• HACHIYA TAKASHI

  Second Department of Internal Medicine Kyoto Prefectural University of Medicine Kyoto

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