Effect of prostaglandin E1 on renin and aldosterone in hypertensive patients.
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概要
- 論文の詳細を見る
The effect of prostaglandin E<SUB>1</SUB> (PGE<SUB>1</SUB>) on plasma renin activity (PRA) and plasma aldosterone concentration (PAC) was studied in the hypertensive subjects treated with without75mg indomethacin or60mg propranolol for a week. Subsequent to the treatment with indomethacin for a week, PRA and PAC levels were decreased as compared to the control, without changes in the blood pressure and heart rate. During the infusion of PGE<SUB>1</SUB>, the blood pressure was decreased and the pulse rate was increased. PRA and PAC levels were also elevated. These changes of parameters were not different between the control and the indomethacin-treated subjects. PRA and PAC were suppressed after the treatment with propranolol. With the infusion of PGE<SUB>1</SUB>, the level of PRA was not significantly elevated, while, PAC was significantly increased by the infusion of100ng/Kg/min of PGE<SUB>1</SUB>. During the infusion of PGE<SUB>1</SUB>, the blood pressure was decreased while the pulse rate was increased in the subjects treated with propranolol. However, the elevation of the pulse rate was less remarkable than the control. These data indicate that PGE, have important roles in the regulation of the release of renin and aldosterone. These findings also suggest that PGE<SUB>1</SUB>may act to stimulate the secretion of aldosterone in man.
- 社団法人 日本内分泌学会の論文
著者
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TAKAHASHI HAKUO
Second Department of Medicine, Kyoto Prefectural University of Medicine
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TAKASHINA RYOSAKU
Second Department of Internal Medicine Kyoto Prefectural University of Medicine
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HACHIYA TAKASHI
Second Department of Surgery, Hamamatsu University School of Medicine
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KAJITA YOSHIHIRO
Second Department of Internal Medicine, Kyoto Prefectural University of Medicine
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MIYAZAKI TADAYOSHI
Second Department of Internal Medicine Kyoto Prefectural University of Medicine Kyoto
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OCHI YUKIO
Second Department of Internal Medicine Shiga University of Medical Science
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Ijichi Hamao
Second Department Of Internal Medicine Kyoto Prefectural University Of Medicine
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YOSHIMURA MANABU
Second Department of Internal Medicine Kyoto Prefectural University of Medicine Kyoto
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YOSHIMURA MANABU
Second Department of Internal Medicine, Kyoto Prfectural University of Medicine
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TAKAHASHI Hakuo
Second Department of Internal Medicine, Kyoto Prefectural University of Medicine
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IJICHI HAMAO
Second Department of Internal Medicine, Kyoto Prfectural University of Medicine
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KAJITA YOSHIHIRO
Second Department of Internal Medicine Kyoto Prefectural University of Medicine Kyoto
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KAJITA YOSHIHIRO
Second Department of Internal Medicine, Kyoto Prfectural University of Medicine
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HACHIYA TAKASHI
Second Department of Internal Medicine Kyoto Prefectural University of Medicine Kyoto
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TAKASHINA RYOSAKU
Second Department of Internal Medicine, Kyoto Prfectural University of Medicine
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MIYAZAKI TADAYOSHI
Second Department of Internal Medicine, Kyoto Prfectural University of Medicine
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