Effect of Sodium Loading and Depletion on Vascular Reactivity and Prostacyclin Generation : IX Conference on the Pathogenesis of Hypertension

概要

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In order to estimate the modulatory activity of Prostacyclin (PGI_2 ) to the vascular reactivity, pressor responses to angiotensin II (A II) and noradrenaline (NA) and PGI_2 generation of aorta were measured using the rats of sodium loading or of sodium depletion. On the sodium loading, the blood pressure increased gradually and plasma renin activity (PRA) and plasma aldosterone concentration (PAC) were decreased. The pressor responses to A II and NA were enhanced by sodium loading. The PGI_2 generation of aorta was enhanced at the initial stage of sodium loading and decreased thereafter. The increased generation of PGI_2 may represent the adaptive mechanism for the attenuation of the sustained elevation in blood pressure. In sodium depletion, the pressor responses to A II and NA were decreased, and PRA and PAC were elevated. PGI_2 generation of aorta was also increased. These findings suggested that PGI_2 could participate in blood pressure control mechanism on sodium loading and depletion.
社団法人日本循環器学会の論文
1980-06-20