The Role of Hypothalamo-sympathetic Nerve System to Maintain High Blood Pressure in DOCA Hypertensive Rats : IX Conference on the Pathogenesis of Hypertension

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Effects of calcium ionophore, A23187, on prostaglandin E_2 and renin release, and the interrelationship were investigated in anesthetized dogs. PGE_2 concentration in arterial and renal venous plasma was measured by radioimmunoassay, and secretion rate (pg/g・min) from the kidney was calculated. The renin secretion rate (ng/g・min) was calculated simultaneously. Intrarenal infusion of A23187 at a rate of 0.5 mg/min for 2 min resulted in a significant increase in RBF. PGE_2 Secretion rate increased from 61 ± 26 to 1012 ± 566 1 222 ± 500 and 388 ± 125 at 5, 9 and 17 min. Renin secretion rate also increased from 1.4 ± 0.8 to 2.3 ± 1.3, 5.8 ± 2.7 and 5.9 ± 1.6 at 5, 9 and 17 min. However, systemic administration of A23187 at a rate of 0.5 mg/min for 2 min did not alter the parameter. Thus, intrarenal infusion of A23187 affects RBF, renin release and PGE_2 release directly within the kidney. In indomethacin treated dogs (5 mg/kg, i.v.) intrarenal infusion of A231 87 significantly decreased RBF. The renin release with A23187 was also abolished with indomethacin as well as PGE_2 release. These results suggest that calcium mobilization within the kidney plays an important role in PGE_2 Synthesis and release, and that the renal vasodilation and renin release are secondary effects of renal PGs Synthesis and release.
社団法人日本循環器学会の論文
1980-06-20