ENHANCED RENAL SYMPATHETIC NERVE ACTIVITY IN RESPONSE TO SALT LOADING IN RATS
スポンサーリンク
概要
- 論文の詳細を見る
To analyze the conflicting data on the relationship between sodium intake and sympathetic activity, the effects of a chronically excessive intake of sodium on renal sympathetic activity and blood pressure were investigated in normotensive rats. Renal sympathetic activity was estimated by urinary excretion of free norepinephrine (NE) and the turnover of NE in the kidneys. Blood pressure increased in rats receiving a high sodium diet when compared with that of the basal sodium diet. Urinary-free NE, epinephrine (E) and dopamine (DA) excretions in rats receiving a high sodium diet were enhanced significantly from those in the basal sodium diet. The turnover of NE in the kidneys was more enhaced in the high sodium group than in the basal sodium group. By blocking the sympathetic tone with ganglionic blockade, hexamethonium, enhanced excretion of urinary NE and elevation of blood pressure in response to salt loading were blocked to the levels of the basal sodium diet. These results suggest that a chronically exessive intake of sodium enhances the renal sympathetic and adreno-medullary activities, leading to a rise in blood pressure in normotensive rats.
- 社団法人日本循環器学会の論文
- 1986-05-20
著者
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Yoshimura Manabu
Department Of Clinical Laboratory And Medicine Kyoto Prefectural University Of Medicine
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Yoshimura Manabu
Department Of Clinical And Laboratory Medicine Kyoto Prefectural University Of Medicine
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Ijichi H
2nd Department Of Medicine Kyoto Prefectural University Of Medicine
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Takeda K
Kyoto Industrial Health Association
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YOSHIMURA MANABU
The Second Department of Internal Medicine, Kyoto Prefectural University of Medicine
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KAMBARA SEIICHI
The Second Department of Internal Medicine, Kyoto Prefectural University of Medicine
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TAKAHASHI HAKUO
The Second Department of Internal Medicine, Kyoto Prefectural University of Medicine
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IJICHI HAMAO
The Second Department of Internal Medicine, Kyoto Prefectural University of Medicine
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SASAKI Susumu
The Second Department of Medicine, Kyoto Prefectural University of Medicine
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TAKEDA Kazuo
The Second Department of Medicine, Kyoto Prefectural University of Medicine
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FUKUYAMA Masaki
Kyoto Prefectural University of Medicine, The Second Department of Medicine
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YAMAZAKI HIDEAKI
The Second Department of Internal Medicine, Kyoto Prefectural University of Medicine
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LEE LI-CHIK
The Second Department of Internal Medicine, Kyoto Prefectural University of Medicine
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FUKUYAMA MASAKI
The Second Department of Internal Medicine, Kyoto Prefectural University of Medicine
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Sasaki Susumu
Department Of Medicine Akashi City Hospital
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Takahashi Hakuo
The Second Department Of Medicine Kyoto Prefectural University Of Medicine
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Lee Li-chik
The 2nd Depertment Of Internal Medicine Kyoto Prefectural University Of Medicine
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Kambara Seiichi
The Second Department Of Internal Medicine Kyoto Prefectural University Of Medicine
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Fukuyama Masaki
Kyoto Prefectural University Of Medicine The Second Department Of Medicine
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Yamasaki Hideaki
The Second Department Of Internal Medicine Kyoto Prefectural University Of Medicine
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Sasaki Susumu
Division Of Hypertension And Nephrology Department Of Medicine Kyoto Prefectural University School O
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Takeda Kazuo
The Second Department of Internal Medicine, Kyoto Prefectural University of Medicine
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Sasaki Susumu
The Second Department of Internal Medicine, Kyoto Prefectural University of Medicine
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