INTRACEREBROVENTRICULAR INJECTIONS OF ENDOTHELIN INCREASE ARTERIAL PRESSURE IN CONSCIOUS RATS : The 53th Annual Scientific Session of the Japanese Circulation Society
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概要
- 論文の詳細を見る
We investigated the possible effects of endothelin (ET) on the central regulation of arterial pressure by injecting ET intracerebroventricularly (ICV) into conscious rats. ICV injections of ET caused dose-dependent elevation of arterial pressure and increase of heart rate. The first reaction was abolished by bunazosin. an α_1-adrenergic blocker. ,injected intravenously. However. the increase in arterial pressure and heart rate caused the rats. injected with ET ICV, to roll to the left on their long axis for 20-30 min, followed by prolonged sedation. Furthermore, the pressor responses and tachycardia were significantly attenuated by the ICV pretreatment with nicardipine. a calcium channel blocker, and nicorandil. a nitrate derivative. respectively-These results suggest that ET may elevate the intracellular Ca^<2+> concentration ([Ca^<2+>]i_) of sympathetic nerve activity regulatory neurons of the brain. leading to an accelerated outflow of sympathetic nerve activity and cause the elevation of arterial pressure.
- 社団法人日本循環器学会の論文
- 1990-06-20
著者
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Nishimura Masato
Department of Cardiovascular Medicine, Abashiri Kohsei General Hospital
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Hachiya T
Midorigaoka Hospital
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Takahashi Hakuo
Department Of Clinical Sciences And Laboratory Medicine Kansai Medical University
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YOSHIMURA Manabu
Department of Clinical Laboratory and Medicine, Kawaramachi-hirokoji
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Yoshimura Manabu
Department Of Clinical Laboratory And Medicine Kyoto Prefectural University Of Medicine
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Yoshimura Manabu
Department Of Clinical And Laboratory Medicine Kyoto Prefectural University Of Medicine
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Takahashi Hakuo
Department Of Cardiology Rakusai Newtown Hospital Kansai Medical University
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Iyoda Isao
Kyoto Prefectural University Of Medicine The Second Department Of Medicine
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IKEGAKI IWAO
Department of Clinical Laboratory and Medicine, Kyoto Prefectural University of Medicine
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MATSUSAWA MAKOTO
Department of Clinical Laboratory and Medicine, Kyoto Prefectural University of Medicine
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NAKANISHI TADASHI
Cardiovascular Division, Department of Medicine, Nagitsuji Hospital
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HIRABAYASHI MASAMI
Cardiovascular Division, Department of Medicine, Nagitsuji Hospital
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Ikegaki Iwao
Department Of Clinical Laboratory And Medicine Kyoto Prefectural University Of Medicine
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Yoshimura Manabu
Department Of Anesthesiology-resuscitology Yamaguchi University Graduate School Of Medicine
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Takahashi Hakuo
The Second Department Of Medicine Kyoto Prefectural University Of Medicine
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Matsuzawa Makoto
Department Of Clinical Laboratory And Medicine Kyoto Prefectural University Of Medicine
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Nishimura Masato
Department Of Clinical And Laboratory Medicine Kyoto Prefectural University Of Medicine
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Nakanishi Tadashi
Department Of Clinical Laboratory And Medicine
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Takahashi H
Department Of Clinical Sciences And Laboratory Medicine Kansai Medical University
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Hirabayashi Masami
Cardiovascular Division Department Of Medicine Nagitsuji Hospital
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Yoshimura Manabu
Department Of Clinical Laboratory And Medicine And The Third Department Of Internal Medicine Kyoto P
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