ATTENUATED DEVELOPMENT OF HYPERTENSION BY CHRONIC ADMINISTRATION OF BROMOCRIPTINE IN DOCA-SALT HYPERTENSIVE RATS
スポンサーリンク
概要
- 論文の詳細を見る
The aim of the study was to investigate whether or not the development of hypertension is influenced by chronic treatment with bromocriptine and/or domperidone. Rats treated with DOCA-salt were divided into 4 groups : control with vehicle, bromocriptine, bromocriptine with domperidone, and domperidone. Increased blood pressure by DOCA-salt treatment was significantly suppressed by treatment with bromocriptine and this bromocriptine suppression was significantly blocked by treatment with domperidone. Increased urinary excretion of norepinephrine by DOCA-salt treatment was significantly suppressed by bromocriptine and the inhibiting effect of bromocriptine disappeared with domperidone. In the four groups of rats, there were significant correlations between systolic blood pressure and urinary excretion of norpinephrine, systolic blood pressure and urinary excretion of epinephrine, and urinary excretion of dopamine and sodium. These results suggest that the chronic effect of bromocriptine is to suppress development of DOCA-salt hypertension, mainly through peripheral mechanisms which are involved in the decreased release of norepinephrine.
- 社団法人日本循環器学会の論文
- 1986-11-20
著者
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Okajima Hiroshi
Department Of Anatomy Kyoto Prefectural University Of Medicine
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Yoshimura Manabu
Department Of Clinical Laboratory And Medicine Kyoto Prefectural University Of Medicine
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Yoshimura Manabu
Department Of Clinical And Laboratory Medicine Kyoto Prefectural University Of Medicine
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Ijichi H
2nd Department Of Medicine Kyoto Prefectural University Of Medicine
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YOSHIMURA MANABU
The Second Department of Internal Medicine, Kyoto Prefectural University of Medicine
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KAMBARA SEIICHI
The Second Department of Internal Medicine, Kyoto Prefectural University of Medicine
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OKABAYASHI HIDEOKI
The Second Department of Internal Medicine, Kyoto Prefectural University of Medicine
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TAKAHASHI HAKUO
The Second Department of Internal Medicine, Kyoto Prefectural University of Medicine
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IJICHI HAMAO
The Second Department of Internal Medicine, Kyoto Prefectural University of Medicine
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Takahashi Hakuo
The Second Department Of Medicine Kyoto Prefectural University Of Medicine
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Okabayashi Hideoki
2nd Department Of Medicine Kyoto Prefectural University Of Medicine
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Okamura H
Department Of Anatomy Kyoto Prefectural University Of Medicine
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Okamura Hiro-oki
Department Of Audio-vestibular Neuroscience Tokyo Medical And Dental University
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Kambara Seiichi
The Second Department Of Internal Medicine Kyoto Prefectural University Of Medicine
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Okamura Hiro-oki
Department Of Otolaryngology Tokyo Medical And Dental University
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