NICORANDIL (2-NICOTINAMIDOETHYL NITRATE) INHIBITS BOTH VASO-DILATING AND -CONSTRICTING EFFECTS OF ENDOTHELIN IN A VASCULARLY ISOLATED HIND-LIMB PREPARATION IN RATS
スポンサーリンク
概要
- 論文の詳細を見る
Effects of nicorandil (2-nicotinamidoethyl nitrate), a nitrate derivative with a K^+ channel-opening action, on endothelin-1 (ET)-induced effects on peripheral blood vessels were studied using a hind-limb perfusion preparation in rats. ET injected into this circuit increased the perfusion pressure for more than 30 min following a transient, initial vasodepression of the perfusion system. The magnitude of both responses was dose-dependent. Pretreatments with nicorandil infused into this preparation significantly attenuated both the initial vasodilation and the sustained vasoconstriction caused by ET. The initial vasodepression caused by ET could be mediated by the release of endothelium-derived relaxing factor (EDRF). The sustained phase would be due to increased intracellular calcium elicited by ET. Nicorandil inhibited both the initial and the sustained phase of the ET-responses, probably by inhibition of intracellular phosphoinositide metabolism in both endothelium and vascular smooth muscle cells.
- 社団法人日本循環器学会の論文
- 1991-07-20
著者
-
Nishimura Masato
Department of Cardiovascular Medicine, Abashiri Kohsei General Hospital
-
Hachiya T
Midorigaoka Hospital
-
Takahashi Hakuo
Department Of Clinical Sciences And Laboratory Medicine Kansai Medical University
-
YOSHIMURA Manabu
Department of Clinical Laboratory and Medicine, Kawaramachi-hirokoji
-
Yoshimura Manabu
Department Of Clinical Laboratory And Medicine Kyoto Prefectural University Of Medicine
-
Yoshimura Manabu
Department Of Clinical And Laboratory Medicine Kyoto Prefectural University Of Medicine
-
Takahashi Hakuo
Department Of Cardiology Rakusai Newtown Hospital Kansai Medical University
-
NAKANISHI Tadashi
Department of Clinical Laboratory and Medicine, Kyoto Prefectural University of Medicine
-
Iyoda Isao
Kyoto Prefectural University Of Medicine The Second Department Of Medicine
-
Sakamoto Masatoshi
Department of Clinical Laboratory and Medicine, Kyoto Prefectural University of Medicine
-
SAKAMOTO MASANORI
Department of Clinical Laboratory and Medicine, Kyoto Prefectural University of Medicine
-
IKEGAKI IWAO
Department of Clinical Laboratory and Medicine, Kyoto Prefectural University of Medicine
-
Ikegaki Iwao
Department Of Clinical Laboratory And Medicine Kyoto Prefectural University Of Medicine
-
Yoshimura Manabu
Department Of Anesthesiology-resuscitology Yamaguchi University Graduate School Of Medicine
-
Takahashi Hakuo
The Second Department Of Medicine Kyoto Prefectural University Of Medicine
-
Nishimura Masato
Department Of Clinical And Laboratory Medicine Kyoto Prefectural University Of Medicine
-
Sakamoto Masatoshi
Department Of Clinical Laboratory And Medicine Kyoto Prefectural University Of Medicine
-
Nakanishi Tadashi
Department Of Clinical Laboratory And Medicine
-
Takahashi H
Department Of Clinical Sciences And Laboratory Medicine Kansai Medical University
-
Nakanishi Tadashi
Department Of Cardiovascular Medicine Kyoto Prefectural University School Of Medicine
-
Yoshimura Manabu
Department Of Clinical Laboratory And Medicine And The Third Department Of Internal Medicine Kyoto P
-
Sakamoto Masanori
Department Of Applied Physics Faculty Of Engineering University Of Tokyo
関連論文
- Possible Contribution of Ischemia of the Conus Branch to Induction or Augmentation of Brugada Type Electrocardiographic Changes in Patients With Coronary Artery Disease
- Monte Carlo simulation for evaluation of the efficacy of carbapenems and new quinolones against ESBL-producing Escherichia coli
- Flow cytometric analysis of Thy-1 expression in myelodysplastic syndrome
- Flow cytometric analysis of Thy-1 expression in CD34-positive acute leukemia
- IS005 Vascular Smooth Muscle Cell(VSMC)-Specific Overexpression of Angiotensin type2(AT2)Receptor Causes Endothelium-dependent Vasodilation via bradykinin/NO/cGMP pathway
- IS040 Angiotensin Type 2 (AT2) Receptor Inhibits AT1-mediated Intracelluar Alkalosis to Enhance Kinik Production in Vascular Smooth Muscle Cells From Vascular-targeted AT2 Transgenic Mice
- IS050 Cardiac-Specific Overexpression of Angiotensin AT2 receptor Causes Attenuated Response to AT1 receptor - Mediated Chronotropic Action
- Association of Human Hepatocyte Growth Factor with Hemodialysis Hypotension
- Restriction of Dietary Sodium May Enhance Nitric Oxide Production in Rats
- Mechanism of Hypertension Induced by Chronic Inhibition of Nitric Oxide in Rats
- -0642- Angiotensin II inhibits L-type Ca current in pacemaker cells isolated from the rabbit sinoatrial node(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
- Urinary Excretion of Free Dopamine and Digoxinlike Substances Correlates with Endogenous Secretion of Insulin in Normotensive Adults, but Not in Hypertensive Subjects
- Does Dopamine Act on Myocardial Cells?
- Diagnostic Significance of Dopamine Estimation Using Plasma and Urine in Patients with Adrenal and Renal Insufficiency, Renal Transplantation and Hypertension
- -0338- CHANGES IN DIETARY SALT INTAKE MAY PLAY A ROLE IN THE REGULATION OF RENIN GENE EXPRESSION IN THE HYPOTHALAMUS OF RATS(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
- AN ATP-SENSITIVE K^+ CHANNEL IN THE BRAIN PLAYS A ROLE IN ARTERIAL PRESSURE REGULATION DURING ACUTE CEREBRAL ISCHEMIA
- BETA-3 ADRENERGIC AGONIST, BRL-26830A, AND ALPHA/BETA BLOCKER, AROTINOLOL, MARKEDLY INCREASE REGIONAL BLOOD FLOW IN THE BROWN ADIPOSE TISSUE IN ANESTHETIZED RATS
- NICORANDIL (2-NICOTINAMIDOETHYL NITRATE) INHIBITS BOTH VASO-DILATING AND -CONSTRICTING EFFECTS OF ENDOTHELIN IN A VASCULARLY ISOLATED HIND-LIMB PREPARATION IN RATS
- INTRACEREBROVENTRICULAR INJECTIONS OF ENDOTHELIN INCREASE ARTERIAL PRESSURE IN CONSCIOUS RATS : The 53th Annual Scientific Session of the Japanese Circulation Society
- MEASUREMENT OF DIGITAL ARTERIAL PRESSURE IN PATIENTS WITH ESSENTIAL HYPERTENSION
- -P115-THE EFFECTS OF ENDOTHELIN ON CENTRAL REGULATION OF ARTERIAL PRESSURE : INTRACEREBROVENTRICULAR INJECTION OF ENDOTHELIN IN RATS : Hypertension : FREE COMMUNICATIONS(III) : PROCEEDINGS OF THE 53th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION
- Pathophysiological Role of Dopamine on the Development of Hypertension in Rats
- Evidence for a Digitalis-Like Substance in the Hypothalamopituitary Axis in Rats : Implications in the Central Cardiovascular Regulation Associated with an Excess Intake of Sodium
- -491- A LINK BETWEEN THE CENTRAL CARDIOVASCULAR CONTROL AND THE THERMOREGULATION IN SHR : INVOLVEMENT OF BRAIN ANGIOTENSIN II
- -344- INHIBITORY ROLES OF THE HYPOTHALAMIC ATRIAL NATRIURETIC POLYPEPTIDE ON THE VASOPRESSIN RELEASE IN THE SODIUM-LOADED RATS
- HYPOTENSIVE RESPONSES TO CENTRALLY ADMINISTERED TAURINE IN DOCA-SALT HYPERTENSIVE AND SPONTANEOUSLY HYPERTENSIVE RATS
- Hypotension and Hypothalamic Depression Produced by Intracerebroventricular Injections of GABA in Spontaneously Hypertensive Rats : THE 15th CONFERENCE ON THE PATHOGENESIS OF HYPERTENSION
- Salt Elevates Blood Pressure with Biphasic Changes in Hypothalamic Responsiveness : THE 15th CONFERENCE ON THE PATHOGENESIS OF HYPERTENSION
- ATTENUATED DEVELOPMENT OF HYPERTENSION BY CHRONIC ADMINISTRATION OF BROMOCRIPTINE IN DOCA-SALT HYPERTENSIVE RATS
- ENHANCED RENAL SYMPATHETIC NERVE ACTIVITY IN RESPONSE TO SALT LOADING IN RATS
- CENTRALLY INDUCED VASODEPRESSOR AND SYMPATHETIC NERVE RESPONSES TO TAURINE
- Peripheral Origin of Plasma Dopamine : THE 14th CONFERENCE ON THE PATHOGENESIS OF HYPERTENSION
- Renal Denervation Inhibits Hypothalamo-Sympathetic Nerve System in Normotensive and Hypertensive Rats : THE 14th CONFERENCE ON THE PATHOGENESIS OF HYPERTENSION
- ACTIVITIES OF HYPOTHALAMO-SYMPATHETIC NERVOUS SYSTEM DURING DEVELOPING STAGES OF SODIUM-INDUCED HYPERTENSION : Hypertension (II) : FREE COMMUNICATIONS (II) : PROCEEDINGS OF THE 49th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- Reliability of Gadolinium-Enhanced Table Stepping 3D MR Angiography for Screening Test of Atherosclerotic Occlusive Diseases of Lower Extremities
- Computed tomographic air-contrast enema imaging for presurgical examination of colon tumors : assessment with colon phantoms and in patients
- Inflammation May Lead to the Development of Coronary Spasm
- Reduced intestinal apo A-IV mRNA levels in patients with liver cirrhosis
- Comparative Study of Dobutamine Stress Electron-Beam Computed Tomography and Exercise Thallium Scintigraphy in the Diagnosis of Patients With Suspected Coronary Artery Disease
- Therapeutic Angiogenesis for Patients with Limb Ischemia by Autologous Transplantation of Bone Marrow Cells : Randomized Controlled Trial
- Angiogenesis for Critical Limb Ischemia Using Autologous Bone Marrow Cell Transplantation
- Does high-dose opioid anesthesia exacerbate ischemic spinal cord injury in rabbits?
- Prediction of postoperative delirium after abdominal surgery in the elderly
- Electron-Beam CT Angiography for Thoracic Aortic Aneutysm and Electrocardiographically Triggered Scan
- New Insights into the Therapeutic Management of Morning Hypertension with α_1-Adrenergic Receptor Blockers
- PJ-328 Pathophysiological roles of Endogenous Digitalis, Marinobufotoxin in Spontaneous Hypertensive Rat(Hypertension, basic(03)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- Differences in antimicrobial susceptibility breakpoints for Pseudomonas aeruginosa, isolated from blood cultures, set by the Clinical and Laboratory Standards Institute (CLSI) and the Japanese Society of Chemotherapy
- Serum hepatocyte growth factor levels in Henoch-Schonlein purpura
- Endogenous Digitalislike Factor: An Update
- CENTRALLY INHIBITORY EFFECT OF ADRENALLINE ON CARDIOVASCULAR AND SYMPATHETIC NERVE SYSTEM IN URETHANE ANESTHETIZED RAT
- KCl Inhibits Hypothalamic Activity to Attenuate Hypertension in DOCA-salt Rats : THE 13TH CONFERENCE ON THE PATHOGENESIS OF HYPERTENSION
- Centrally-Induced Vasopressor Responses to Sodium-Potassium Adenosine Triphosphatase Inhibitor, Ouabain, may be Mediated Via Angiotensin II in the Anteroventral Third Ventricle in the Brain : THE 13TH CONFERENCE ON THE PATHOGENESIS OF HYPERTENSION
- EFFECT OF BROMOCRIPTINE ON BLOOD PRESSURE AND PRESSURE RESPONSE TO EXERCISE IN PATIENTS WITH ESSENTIAL HYPERTENSION : Hypertension(I) : I : 48 Annual Scientific Meeting, Japanese Circulation Society
- RETARDATION OF THE DEVELOPMENT OF HYPERTENSION IN DOCA-SALT RATS BY RENAL DENERVATION
- The Role of Prostaglandins in the Regulation of Blood Pressure with Special Reference to Vascular Reactivity : SYMPOSIUM ON BLOOD PRESSURE AND VASOACTIVE SUBSTANCES
- CENTRALLY INDUCED VASOPRESSOR AND SYMPATHETIC NERVE RESPONSES TO CARBACHOL IN RATS
- CENTRALLY-INDUCED VASOPRESSOR RESPONSES TO OUABAIN ARE AUGMENTED IN SPONTANEOUSLY HYPERTENSIVE RATS : PROCEEDINGS OF THE 47th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY : Hypertension
- HETEROGENEITY OF VASODEPRESSOR RESPONSES BY CAPTOPRIL : Hypertension (I) : 46th Annual Scientific Meeting, Japanese Circulation Society
- Liquid Chromatography Mass Spectrometric Analysis of Ouabainlike Factor in Biological Fluid
- Increased Receptor Binding by Bovine (b) TSH Bound to Monoclonal Antibody to bTSHβ-subunit
- All-trans Retinoic Acid Inhibits Vascular Smooth Muscle Cell Proliferation Targeting Multiple Genes for Cyclins and Cyclin-Dependent Kinases
- Possible Role of Chronic Infection With Chlamydia Pneumoniae in Japanese Patients With Acute Myocardial Infarction
- Increases in Plasma Ouabainlike Immunoreactivity during Surgical Extirpation of Pheochromocytoma
- Thyroid Stimulating Immunoglobulin (TSI) in Graves' Disease
- ENDOGENOUS BRAIN ANGIOTENSIN II-MEDIATED SYMPATHETIC NERVE RESPONSES ARE NOT AUGMENTED IN MATURE SPONTANEOUSLY HYPERTENSIVE RATS
- PJ-119 Effect of Anti-platelet Drugs at Angiogenic Cell Therapy(Peripheral circulation-8 (H) PJ20,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- Anti-platelet Drugs Inhibited Angiogenesis by Bone Marrow Cell Implantation(Peripheral Circulation/Vascular Disease (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Therapeutic Angiogenesis Therapy by Autologous Bone Marrow Cell Transplantation for Critical Limb Ischemia(An Update on the Contemporary Management of Peripheral Arterial Disease, The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Angiogenesis and Angiotensin II : Differential Postnatal Angiogenic Activities Unmasked by Gene-Engineered Mouse Models of Angiotensin AT1 and AT2 Receptor Subtypes
- Renin-Angiotensin System in Proliferative Diabetic Retinopathy and Its Gene Expression in Cultured Human Muller Cells
- Gravity Load Collapse of Reinforced Concrete Columns with Brittle Failure Modes
- -1072-BLOCK OF Na^+ CHANNELS BY IMIPRAMINE IN GUINEA-PIG CARDIAC VENTRICULAR CELLS : THE 54th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- MR Imaging Features of Solid-pseudopapillary Tumor of the Pancreas
- CENTRALLY-INDUCED VASOPRESSOR AND SYMPATHETIC NERVE RESPONSES TO INTRACEREBROVENTRICULAR OR INTRAHYPOTHALAMIC INJECTIONS OF OUABAIN IN THE DOCA-SALT HYPERTENSIVE RAT : Hypertension (II) : FREE COMMUNICATIONS (II) : PROCEEDINGS OF THE 49th ANNUAL SCIENTIFI
- ENDOGENOUS BRAIN ANGIOTENSIN II-MEDIATED SYMPATHETIC NERVE RESPONSES ARE NOT AUGMENTED IN MATURE SPONTANEOUSLY HYPERTENSIVE RATS : Hypertension (I) : 46th Annual Scientific Meeting, Japanese Circulation Society
- CENTRAL CHOLINERGIC VASOPRESSOR MECHANISMS IN SPONTANEOUSLY HYPERTENSIVE RATS : Hypertension (I) : 46th Annual Scientific Meeting, Japanese Circulation Society
- The Role of Brain Angiotensin II in the Mechanism of the Pressor Responses to Intracisternal Injection of Hypertonic NaCl in Urethane Anesthetized Rats : THE 11th CONFERENCE ON THE PATHOGENESIS OF HYPERTENSION
- Solar Selective Absorber Coating Composed of Aluminum and Nitrogen with High Performance Induced by Surface Roughness
- Solar Light Absorption Property of Nano-Structured Silver Layer and Application to Photo-Thermal Energy Conversion Coating
- Solar Light Absorption Property of Sputtered Al-N Films with Enhanced Surface Roughness during Film Growth(Surfaces, Interfaces, and Films)
- Clinical differences between brain natriuretic peptide and N-terminal pro-brain natriuretic peptide
- Screening of antibiotics resistance to Enterobacteriaceae, Pseudomonas aeruginosa, and Acinetobacter baumannii by an advanced expert system
- Epidemiological study of Candida infections in blood : susceptibilities of Candida spp. to antifungal agents, and clinical features associated with the candidemia
- Sympathetic and Pressor Hyperresponsiveness to Intracisternal Injections of Hypertonic NaCl in DOCA Hypertensive Rats : THE 10th CONFERENCE ON THE PATHOGENESIS OF HYPERTENSION
- CENTRALLY-INDUCED VASOPRESSOR RESPONSES TO CONJUGATED ESTROGENS : Kidney・Hypertension : FREE COMMUNICATIONS (Abstract) : 45 Annual Scientific Meeting, Japanese Circulation Society
- Structural-Color-Control by AlN Coating on Rough-Surface Al Film
- Inhibitory Effect of Thyroid Blocking Antibody (TBAb) on the Thyroid Stimulatory Effect of Human Chorionic Gonadotropin (HCG) and Equine Chorionic Gonadotropin (ECG)
- The central mechanism underlying hypertension : a review of the roles of sodium ions, epithelial sodium channels, the renin-angiotensin-aldosterone system, oxidative stress and endogenous digitalis in the brain
- Effect of sodium loading and depletion on cyclic nucleotides in plasma and aorta. Interaction between prostacyclin and cyclic nucleotides.
- Immunological similarity of thyroid stimulating antibody (TSAb) and thyroid blocking antibody (TBAb) with animal IgG
- Neutralization and purification of thyroid stimulating antibody (TSAb) and thyroid blocking antibody (TBAb) by heterophilic antibody to animal IgG in Graves' disease
- Enhanced synthesis of renal dopamine and impaired natriuresis in spontaneously hypertensive rats (SHRs)
- Pathophysiological Role of Augmented Catecholamine Content in SHR Heart
- Effect of inhibition of dopamine biosynthesis on the development of hypertension in SHR
- Defect of Dopaminergic Sodium-handling in SHR Kidneys
- Significance of Brain Amiloride-Sensitive Sodium Channels in the Pressor Mechanism of SHRSP/Izm
- A Novel Method Detecting Hypercoagulability in Small Experimental Animals:Comparison between Spontaneously Hypertensive and Normotensive Rats
- Different susceptibility of HCl-induced gastric ulceration and the role of gastric catecholamine in the spontaneously hypertensive rats
- An ATP-sensitive K+ Channel in the Brain Plays a Role in Arterial Pressure Regulation During Cerebral Ischemia:Comparison between SHR and WKY rats
- Solar Light Absorption Property of Sputtered Al–N Films with Enhanced Surface Roughness during Film Growth