Possible Role of Chronic Infection With Chlamydia Pneumoniae in Japanese Patients With Acute Myocardial Infarction
スポンサーリンク
概要
- 論文の詳細を見る
Chlamydia pneumoniae, a common human respiratory pathogen, has been implicated in the pathogenesis of coronary heart diseases (CHD) in several seroepidemiological studies. The present case-control study investigated the relation between serologic evidence of C. pneumoniae infection and CHD in a Japanese population. Two groups of cases were enrolled: 26 patients with acute myocardial infarction (AMI) and 46 patients with effort angina pectoris (e-AP). Their data were compared with 58 age-matched healthy controls and also compared with 53 patients with vasospastic angina (VSA) as pathological control subjects. Anti-C. pneumoniae specific IgA and IgG antibody titers were measured by enzyme-linked immunosorbent assay (ELISA). The mean indices of IgG-type antibody in AMI and e-AP were not significantly different from those in either the normal controls or VSA group. On the other hand, the mean indices of IgA-type antibody in AMI were significantly higher than in the normal controls (1.39±0.83 in AMI vs 0.84±0.58 in controls, p<0.001) and VSA (1.39±0.83 in AMI vs 1.05±0.61 in VSA, p<0.05) group. However, the differences in the IgA titers in the e-AP group compared with the normal controls did not reach a significant level. The odds ratio associated with the seropositivity of IgA for AMI against the normal controls was 3.89 (95% confidence interval (CI): 1.16-13.10) and that against VSA was 6.90 (95% CI: 1.73-27.52) after adjustment for risk factors for CHD and/or age, sex and smoking status. In 6 patients the elevated IgA titers were sustained even at 3 months after the episode of AMI. These results suggest that seropositivity for IgA-type antibody against C. pneumoniae may be a significant risk factor for the development of AMI. The possible mechanisms include chronic inflammation in the coronary artery due to persistent C. pneumoniae infection.
- 社団法人日本循環器学会の論文
- 2000-10-20
著者
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Hachiya T
Midorigaoka Hospital
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Takahashi Hakuo
Department Of Clinical Sciences And Laboratory Medicine Kansai Medical University
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KOMIYAMA Yutaka
Department of Astronomy, School of Science, The University of Tokyo
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Takahashi Hakuo
Department Of Cardiology Rakusai Newtown Hospital Kansai Medical University
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HARA Katsuko
Department of Clinical Sciences and Laboratory Medicine, Kansai Medical University
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Hara Katsuko
Department Of Clinical Sciences And Laboratory Medicine Kansai Medical University
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Komiyama Yutaka
Department Of Clinical Sciences And Laboratory Medicine Kansai Medical University
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Komiyama Yutaka
Department Of Astronomy School Of Science The University Of Tokyo
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Takahashi Hakuo
The Second Department Of Medicine Kyoto Prefectural University Of Medicine
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KOSAKA Chiya
the Department of Clinical Sciences and Laboratory Medicine, Kansai Medical University
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KOSAKA Chiya
Department of Clinical Sciences and Laboratory Medicine, Kansai Medical University
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Kosaka Chiya
Department Of Clinical Sciences And Laboratory Medicine Kansai Medical University
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Takahashi H
Department Of Clinical Sciences And Laboratory Medicine Kansai Medical University
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