HYPOTENSIVE RESPONSES TO CENTRALLY ADMINISTERED TAURINE IN DOCA-SALT HYPERTENSIVE AND SPONTANEOUSLY HYPERTENSIVE RATS

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概要

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• The present study was designed to investigate the short-term effects of intracerebroventricularly-administered taurine in DOCA-salt hypertensive (DOCA), spontaneously hypertensive (SHR) and their respective normotensive control rats anesthetized with urethane. Blood pressure, heart rate and sympathetic nerve activity were consistently decreased following the injection of taurine 150μg per rat in hypertensive rats as well as in normotensive controls of the two groups. Percent changes from the baselines in blood pressure, heart rate and sympathetic nerve activity were significantly larger in DOCA-salt hypertensive rats than those in sham operated rats. In contrast, percent changes in blood pressure and sympathetic nerve activity were not significantly different between spontaneously hypertensive rats and normotensive wistar kyoto rats. These result show that the responses of blood pressure, heart rate and sympathetic nerve activity to intracerebroventricular taurine are different between spontaneously hypertensive rats and DOCA-salt hypertensive rats. It appears that augmented vasodepressor responses to taurine in DOCA-salt hypertensive rats, compared to spontaneously hypertensive rats, are due to enhanced inhibition of the sympathetic outflow.

• 社団法人日本循環器学会の論文
• 1986-12-20

著者

• Inoue Atsushi

  The 2nd Depertment Of Internal Medicine Kyoto Prefectural University Of Medicine

• NAKAGAWA Masao

  the Second Department of Medicine, Kyoto Prefectural University of Medicine

• Yoshimura Manabu

  Department Of Clinical Laboratory And Medicine Kyoto Prefectural University Of Medicine

• Yoshimura Manabu

  Department Of Clinical And Laboratory Medicine Kyoto Prefectural University Of Medicine

• Ijichi H

  2nd Department Of Medicine Kyoto Prefectural University Of Medicine

• Takeda K

  Kyoto Industrial Health Association

• YOSHIMURA MANABU

  The Second Department of Internal Medicine, Kyoto Prefectural University of Medicine

• TAKAHASHI HAKUO

  The Second Department of Internal Medicine, Kyoto Prefectural University of Medicine

• IJICHI HAMAO

  The Second Department of Internal Medicine, Kyoto Prefectural University of Medicine

• INOUE Atsushi

  The Second Department of Medicine, Kyoto Prefectural University of Medicine

• LEE Li-cruk

  The Second Department of Medicine, Kyoto Prefectural University of Medicine

• SASAKI Susumu

  The Second Department of Medicine, Kyoto Prefectural University of Medicine

• TAKEDA Kazuo

  The Second Department of Medicine, Kyoto Prefectural University of Medicine

• Sasaki Susumu

  Department Of Medicine Akashi City Hospital

• Nakagawa Masao

  The Second Department Of Medicine Kyoto Prefectural University Of Medicine

• Takahashi Hakuo

  The Second Department Of Medicine Kyoto Prefectural University Of Medicine

• Lee Li-chik

  The 2nd Depertment Of Internal Medicine Kyoto Prefectural University Of Medicine

• Sasaki Susumu

  Division Of Hypertension And Nephrology Department Of Medicine Kyoto Prefectural University School O

• Takeda Kazuo

  The Second Department of Internal Medicine, Kyoto Prefectural University of Medicine

• Sasaki Susumu

  The Second Department of Internal Medicine, Kyoto Prefectural University of Medicine

• Nakagawa Masao

  The Second Department of Internal Medicine, Kyoto Prefectural University of Medicine

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