Pathophysiological Role of Dopamine on the Development of Hypertension in Rats
スポンサーリンク
概要
- 論文の詳細を見る
The aim of the study is to investigate the pathophysiological role of dopamine (DA) in the development of hypertension in DOCA-salt hypertensive rats and spontaneously hypertensive rats (SHRs). The augmentation of dopaminergic activity by chronic administration of bromocriptine, a DA agonist, suppressed the increase of blood pressure in DOCA-salt hypertensive rats. In contrast, suppression of dopaminergic activity by chronic administration of carbidopa, an inhibitor of dopa decarboxylase, accelerated the development of hypertension in SHRs, and this acceleration was also increased by salt loading. Increased urinary excretion of norepinephrine (NE) by DOCA-salt treatment was suppressed by the treatment of bromocriptine. In contrast, administration of carbidopa and salt loading in SHRs resulted in an increase in renal NE content and in urinary NE and epinephrine (E) excretion and a decrease in urinary sodium excretion. These results suggest that dopaminergic activity participate in the development of hypertension and decreased dopaminergic activity accelerates the development of hypertension in hypertensive rats mainly through the enhancement of peripheral sympathetic nerve activity.
- 社団法人日本循環器学会の論文
- 1987-10-20
著者
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Hachiya T
Midorigaoka Hospital
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Okajima Hiroshi
Department Of Anatomy Kyoto Prefectural University Of Medicine
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Yoshimura Manabu
Department Of Clinical Laboratory And Medicine Kyoto Prefectural University Of Medicine
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Yoshimura Manabu
Department Of Clinical And Laboratory Medicine Kyoto Prefectural University Of Medicine
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Ijichi H
2nd Department Of Medicine Kyoto Prefectural University Of Medicine
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Iyoda Isao
Kyoto Prefectural University Of Medicine The Second Department Of Medicine
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Suga Keisuke
2nd Dep. of Inter. Med. Kyoto Prefectural University of Medicine
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YOSHIMURA MANABU
The Second Department of Internal Medicine, Kyoto Prefectural University of Medicine
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KAMBARA SEIICHI
The Second Department of Internal Medicine, Kyoto Prefectural University of Medicine
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OKABAYASHI HIDEOKI
The Second Department of Internal Medicine, Kyoto Prefectural University of Medicine
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IKEGAIKI IWAO
The Second Department of Internal Medicine, Kyoto Prefectural University of Medicine
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MATSUZAWA MAKOTO
The Second Department of Internal Medicine, Kyoto Prefectural University of Medicine
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SUGA KEISUKE
The Second Department of Internal Medicine, Kyoto Prefectural University of Medicine
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TAKAHASHI HAKUO
The Second Department of Internal Medicine, Kyoto Prefectural University of Medicine
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IJICHI HAMAO
The Second Department of Internal Medicine, Kyoto Prefectural University of Medicine
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Ikegaki Iwao
Department Of Clinical Laboratory And Medicine Kyoto Prefectural University Of Medicine
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Takahashi Hakuo
The Second Department Of Medicine Kyoto Prefectural University Of Medicine
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Matsuzawa Makoto
Department Of Clinical Laboratory And Medicine Kyoto Prefectural University Of Medicine
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Okabayashi Hideoki
2nd Department Of Medicine Kyoto Prefectural University Of Medicine
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Okamura H
Department Of Anatomy Kyoto Prefectural University Of Medicine
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Kambara Seiichi
The Second Department Of Internal Medicine Kyoto Prefectural University Of Medicine
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Takahashi H
Department Of Clinical Sciences And Laboratory Medicine Kansai Medical University
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