Changes in the Cyclic Nucleotides of Rat Thyroid, Pituitary and Plasma Caused by Methylthiouracil Treatment

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概要

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• Changes in the content of cyclic nucleotides (cAMP and cGMP) and related enzyme activities were observed in the rat thyroid, pituitary and plasma during the prolonged increase of endogenous TSH produced by treatment with methylthiouracil (MTU). Experiments were performed after 4 weeks treatment with MTU.<BR>The wet weight and c AMP content per wet weight of the thyroid increased 3 and 1.4 times respectively, but c GMP showed a slight decrease. Pituitary weight increased 1.3 times, but c AMP and c GMP content did not change. The c AMP level in plasma also increased about 1.3 times, but c GMP did not increase.<BR>The c AMP-phosphodiesterase activity in the thyroid, pituitary and plasma was increased 1.9, 1.4 and 1.3 times respectively after MTU treatment, while c GMPphosphodiesterase showed no significant change.<BR>ATPase activity in the thyroid and pituitary was also increased more than 1.5 times after MTU treatment, while 5-nucleotidase activity decreased remarkably. These data indicate that the metabolism of the cyclic nucleotide system in the thyroid is stimulated by TSH.

• 社団法人 日本内分泌学会の論文

著者

• YOSHIMURA Manabu

  Second Department of Internal Medicine. Kyoto Prefectural University of Medicine

• HACHIYA TAKASHI

  Second Department of Surgery, Hamamatsu University School of Medicine

• KAJITA YOSHIHIRO

  Second Department of Internal Medicine, Kyoto Prefectural University of Medicine

• Ochi Y

  Research Institute For Production Development

• MIYAZAKI TADAYOSHI

  Second Department of Internal Medicine Kyoto Prefectural University of Medicine Kyoto

• OCHI YUKIO

  Second Department of Internal Medicine Shiga University of Medical Science

• OCHI YUKIO

  Second Depurtment of Internal Medicine, Shiga Medical Umiversity

• YOSHIMURA MANABU

  Second Department of Internal Medicine Kyoto Prefectural University of Medicine Kyoto

• KAJITA YOSHIHIRO

  Second Department of Internal Medicine Kyoto Prefectural University of Medicine Kyoto

• HACHIYA TAKASHI

  Second Department of Internal Medicine Kyoto Prefectural University of Medicine Kyoto

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