Quinine-resistant Severe Falciparum Malaria Effectively Treated with Atovaquone and Proguanil Hydrochloride Combination Therapy
スポンサーリンク
概要
- 論文の詳細を見る
A 22-year-old Japanese man noticed pyrexia and diarrhea after travel to Guinea. Notable physical findings included hepatosplenomegaly. Treatment with oral quinine and minocycline was started after definitive diagnosis of falciparum malaria by blood smear. Initially, parasitemia and body temperature decreased but by the third night of therapy his temperature increased to 40°C with a slight increase of parasite count. When quinine treatment was changed to atovaquone/proguanil, his temperature dropped immediately and complete plasmodial elimination was confirmed on microscopic examination. Subsequent recrudescence of the disease was not observed. It was concluded that the antimalarial treatment with atovaquone/proguanil might become invaluable in Japan.
- 社団法人 日本内科学会の論文
- 2004-07-01
著者
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YAMADA Tomohiro
Department of Pathogenic Biochemistry, Institute of Natural Medicine, Toyama Medical and Pharmaceuti
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UCHIYAMA Hitoji
Department of Molecular Hematology and Oncology, Graduate School of Medical Science, Kyoto Prefectur
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ARIZONO Naoki
Department of Medical Zoology, Kyoto Prefectural University of Medicine
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TEGOSHI Tatsuya
Department of Medical Zoology, Kyoto Prefectural University of Medicine
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SATO Katsuaki
Department of Applied Physics, Tokyo University of Agriculture and Technology
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Arizono Naoki
Department Of Pathology Shiga University Of Medical Science
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MURAKAMI SADATSUGU
Department of Anatomy, Kyoto Prefectural University of Medicine
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Tegoshi Tatsuya
Department Of Medical Zoology Kyoto Prefectural University Of Medicine
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OKAMOTO Akio
Department of Medicine, Nantan General Hospital
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YONEDA Seiichi
Department of Medicine, Nantan General Hospital
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KAJITA Yoshihiro
Department of Medicine, Nantan General Hospital
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Uchiyama Hitoji
Department Of Medicine Nantan General Hospital
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Okamoto Akio
Department Of Human And Mechanical Systems Engineering Faculty Of Engineering Kanazawa University
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Yoneda Seiichi
Department Of Medicine Nantan General Hospital
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Yamada Tomohiro
Department Of Clinical Pathology Kinki University School Of Medicine
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Murakami Sadatsugu
Department Of Anatomy Kyoto Prefectural University Of Medicine
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Murakami Sadatsugu
Department Of Medicine Nantan General Hospital
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Arizono Naoki
Department Of Medical Zoology Kyoto Prefectural University Of Medicine
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Okamoto Akio
Department Of Medicine Nantan General Hospital
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Sato Katsuaki
Department Of Medicine Nantan General Hospital
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Kajita Yoshihiro
Department Of Medicine Nantan General Hospital
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Kajita Yoshihiro
Department Of Internal Medicine Nantan Hospital
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Yamada Tomohiro
Department Of Medicine Nantan General Hospital
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KAJITA YOSHIHIRO
Department of Internal Medicine Nantan General Hospital
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Sato Katsuaki
Department of Applied Physics, Graduate School of Engineering, Tokyo University of Agriculture and Technology, 2-24-16 Nakacho, Koganei, Tokyo 184-8588, Japan
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SATO Katsuaki
Department of Applied Physics, Faculty of Technology, Tokyo University of Agriculture and Technology
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