Hypoglycemic Effects of Turmeric (Curcuma longa L. Rhizomes) on Genetically Diabetic KK-A^y Mice(Communications to the Editor)
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概要
- 論文の詳細を見る
The turmeric (Curcuma longa L. rhizomes) EtOH extract significantly suppressed an increase in blood glucose level in type 2 diabetic KK-A^y mice. In an in vitro evaluation, the extract stimulated human adipocyte differentiation in a dose-dependent manner and showed human peroxisome proliferator-activated receptor (PPAR)-γ ligand-binding activity in a GAL4-PPAR-γ chimera assay. The main constituents of the extract were identified as curcumin, demethoxycurcumin, bisdemethoxycurcumin, and ar-turmerone, which had also PPAR-γ ligand-binding activity. These results indicate that turmeric is a promising ingredient of functional food for the prevention and/or amelioration of type 2 diabetes and that curcumin, demethoxycurcumin, bisdemethoxycurcumin, and ar-turmerone mainly contribute to the effects via PPAR-γ activation.
- 公益社団法人日本薬学会の論文
- 2005-05-01
著者
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Kuroda M
Laboratory Of Medicinal Pharmacognosy Tokyo University Of Pharmacy And Life Sciences School Of Pharm
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Kuroda Minpei
Laboratory Of Medicinal Pharmacognosy Tokyo University Of Pharmacy And Life Science School Of Pharma
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Nishiyama T
Functional Foods Development Division Kaneka Corporation
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KAWADA Teruo
Laboratory for Molecular Function of Food, Division of Food Science and Biotechnology, Graduate Scho
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Kitahara Mikio
Life Science Research Laboratories Life Science Rd Center Kaneka Corporation
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黒田 明平
東京薬大薬
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Kitano Mitsuaki
Frontier Biochemical And Medical Res. Laboratories Corporate Res. And Dev. Div. Kaneka Corp.
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MIMAKI Yoshihiro
Laboratory of Medicinal Plant Science, School of Pharmacy, Tokyo University of Pharmacy and Life Sci
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Mimaki Yoshihiro
Laboratory Of Medical Plant Science Tokyo University Of Pharmacy And Life Science
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Nishiyama Tozo
Functional Foods Development Division Kaneka Corporation
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Kuroda M
東京薬大
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Nakagawa Kaku
Functional Food Ingredients Div. Kaneka Corp.
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KISHIDA Hideyuki
Life Science Research Laboratories, Life Science RD Center, Kaneka Corporation
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MAE Tatsumasa
Functional Food Ingredients Division, Kaneka Corporation
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Kawada Teruo
Laboratory Of Molecular Function Of Food Division Of Food Science And Biotechnology Graduate School
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TSUKAGAWA Misuzu
Functional Foods Development Division, Kaneka Corporation
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TAKAHASHI Kazuma
Division of Molecular Metabolism and Diabetes, Department of Internal Medicine, Tohoku University Sc
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KITAHARA Mikio
Functional Foods Development Division, Kaneka Corporation
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Mimaki Yoshihiro
Laboratory Of Medicinal Pharmacognosy Tokyo University Of Pharmacy And Life Science School Of Pharma
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Mae Tatsumasa
Functional Food Ingredients Div. Kaneka Corp.
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Kawada Teruo
Laboratory For Molecular Function Of Food Division Of Food Science And Biotechnology Graduate School
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Kuroda Minpei
Laboratory Of Medicinal Pharmacognosy Tokyo University Of Pharmacy And Life Science School Of Pharma
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Takahashi Kazuma
Division Of Molecular Metabolism And Diabetes Department Of Internal Medicine Tohoku University Scho
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Kishida Hideyuki
Frontier Biochemical And Medical Research Laboratories Corporate Research And Development Division K
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Tsukagawa Misuzu
Functional Foods Development Division Kaneka Corporation
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Takahashi Kazuma
Division of Diabetes and Metabolism, Department of Internal Medicine, Iwate Medical University School of Medicine, Japan
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