Influence of OSW-1 [3β, 16β, 17α-Trihydroxycholest-5-en-22-one 16-O-(2-O-4-methoxybenzoyl-β-D-xylopyranosyl)-(1→3)-(2-O-acetyl-α-L-arabinopyranoside)], a Steroidal Saponin, on Endothelium Dependent Relaxation Caused by Acetylcholine in Rat Aorta
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概要
- 論文の詳細を見る
The tension of isolated ring preparation of the aorta from rats was measured isometrically to study the influence of OSW-1 [3β, 16β, 17α-trihydroxycholest-5-en-22-one 16-O-(2-O-4-methoxybenzoyl-β-D-xylopyranosyl)-(1→3)-(2-O-acetyl-α-L-arabinopyranoside)], a steroidal saponin, on the endothelium dependent and independent relaxation caused by acetylcholin (ACh) and sodium nitroprusside (SNP), respectively. OSW-1 (10^<-7> M), which has more than 100 times higher concentration for anti-tumor activity, had no influence on either the endothelium dependent or independent relaxation. OSW-1 (10^<-6>M, 0.9 μg/ml) slightly reduced the endothelium dependent relaxation caused by ACh but did not affect the SNP-induced relaxation. In contrast to OSW-1,1 mg/ml of saponin significantly suppressed the ACh-induced relaxation and shifted the dose-relaxation curve for SNP to the right. OSW-1 (10^<-7> and 10^<-6> M) did not affect the norepinephrine-induced contraction but 1 mg/ml of saponin significantly attenuated it. The results suggest that though the higher concentration of OSW-1 shows weaker influence on the endothelium function compared with saponin, OSW-1 at an anti-tumor dose has no influence on either endothelium or smooth muscle function.
- 公益社団法人日本薬学会の論文
- 1997-04-15
著者
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Honda H
Department Of Pharmacology Tokyo University Of Pharmacy And Life Science
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Honda Hideo
Department Of Pharmacology Tokyo University Of Pharmacy And Life Science
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Honda Hideo
Department Of Ophthalmology Nagoya City University Medical School
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KOGO Hiroshi
Department of Pharmacology, Tokyo University of Pharmacy and Life Science
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Kogo H
Tokyo Univ. Pharmacy & Life Sci. Tokyo Jpn
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Kogo Hiroshi
Department Of Anatomy And Cell Biology Gunma University School Of Medicine
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Mimaki Yoshihiro
Laboratory Of Medical Plant Science Tokyo University Of Pharmacy And Life Science
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Sashida Yutaka
Laboratory Of Medical Plant Science Tokyo University Of Pharmacy And Life Science
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Honda Hideo
東京薬科大学 薬理
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