Effects of Antiestrogens on Ovarian Aldo-Keto Reductase in Relation to Ovulation in Rats.
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概要
- 論文の詳細を見る
The pharmacological effects of antiestrogens on ovarian aldo-keto reductase and ovulation were investigated in rats. The activities of reduction of 13, 14-dihydro-15-keto-PGF<SUB>2α</SUB>, 4-benzoylpyridine and menadione in ovarian cytosol were significantly decreased by antiestrogen treatments, and the ovulation was completely inhibited. However, administration of luteinizing hormone-releasing hormone at 3:00 p.m. on the day of proestrus restored both enzyme activities and ovulation, which were inhibited by antiestrogens, to control levels. These results indicate that nonsteroidal antiestrogen inhibits the luteinizing hormone surge on the day of proestrus in 4-day cycling rats and that ovarian aldo-keto reductase may be closely involved in the ovulatory process in rats.
- 公益社団法人 日本薬理学会の論文
著者
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Kogo Hiroshi
Department Of Anatomy And Cell Biology Gunma University School Of Medicine
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INABA NIRO
Department of Pharmacology and Toxicology, Tokyo College of Pharmacy
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Inazu Norihisa
Department Of Pharmacology And Toxicology Tokyo College Of Pharmacy
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SATOH Tetsuo
Laboratory of Biochemical Pharmacology and Biotoxicology
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Satoh Tetsuo
Laboratory of Biochemical Pharmacology and Biotoxicology, Faculty of Pharmaceuticals Sciences
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