Short Term Hypercholesterolemia Alters N^G-Nitro-L-arginine-and Indomethacin-Resistant Endothelium-Dependent Relaxation by Acetylcholine in Rabbit Renal Artery
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概要
- 論文の詳細を見る
The tension of isolated rings was measured isometrically to compare the NG-nitro-L-arginine- and indomethacin-resistant relaxation by acetylcholine (ACh) in the renal artery from normal rabbits and short term hypercholesterolemia rabbits (0.5% cholesterol chow for 5 weeks). ACh-induced relaxation in the renal artery precontracted with phenylephrine was not influenced by cholesterol-enriched chow. However, in comparison with artery from normal rabbits, the N G-nitro-L-arginine- and indomethacin-resistant endothelium-dependent relaxation by ACh was significantly enhanced by the chow. The resistant part of ACh-induced relaxation was significantly inhibited when the artery was treated with tetraethylammonium or SKF 525a. Results suggest that short term hypercholesterolemia modulates endothelium-derived hyperpolarizing factor-mediated relaxation in rabbit renal artery.
- 社団法人 日本薬理学会の論文
- 2001-02-01
著者
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FUJII Hiroyuki
Department of Cardiology, Yokohama-Minami Kyosai Hospital
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Fujii Hiroyuki
Department Of Cardiology Yokohama-minami Kyosai Hospital
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Honda Hideo
Department Of Pharmacology Tokyo University Of Pharmacy And Life Science
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Honda Hideo
Department Of Ophthalmology Nagoya City University Medical School
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KOGO Hiroshi
Department of Pharmacology, Tokyo University of Pharmacy and Life Science
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Kogo Hiroshi
Department Of Anatomy And Cell Biology Gunma University School Of Medicine
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Kogo Hiroshi
Department Of Pharmacology Tokyo University Of Pharmacy And Life Science
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Notoya Yoko
Department Of Internal Medicine Tokyo Medical University
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MOROE Hiroko
Department of Pharmacology, Tokyo University of Pharmacy and Life Science
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ARAI Katsunori
Department of Internal Medicine, Tokyo Medical University
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Moroe Hiroko
Department Of Pharmacology Tokyo University Of Pharmacy And Life Science
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Arai K
Department Of Internal Medicine Tokyo Medical University
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Fujii Hiroyuki
Department Of Pharmacology Tokyo University Of Pharmacy And Life Science
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