The Expression of Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) and Its Regulation by Ovarian Steroids in Rat Uterine Stromal Cells
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概要
- 論文の詳細を見る
The effects of ovarian steroids on the expression of granulocyte-macrophage colony-stimulating factor (GM-CSF) in rat uterus were examined. Intense expression of GM-CSF mRNA was dispersedly located in the endometrial-myometrial junction and stroma of the uterus. GM-CSF was immunohistochemically localized in stromal cells and luminal epithelium. Ovariectomy significantly reduced the appearance of GM-CSF-mRNA-positive cells and the levels of expression for GM-CSF mRNA in the whole uterus, whereas treatment with 17β-estradiol (E2) or a combination of E2 and progesterone (P4) for 5 days on ovariectomized animals recruited GM-CSF-mRNA-positive cells and stimulated its expression. The combined treatment with E2 and P4 also stimulates the expression for GM-CSF mRNA and the production of immunoreactive GM-CSF in the stromal tissues. These data suggest that the expression of GM-CSF in uterine stromal cells is partially regulated by ovarian steroids.
- 社団法人 日本薬理学会の論文
- 1999-02-01
著者
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Kogo Hiroshi
Department Of Anatomy And Cell Biology Gunma University School Of Medicine
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KUMASAKA Kenichi
Department of Food and Drug Science, Kanagawa Prefectural Public Health Laboratory
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Tamura Kazuhiro
Department Of Endocrine Pharmacology Tokyo University Of Pharmacy And Life Science
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Kumasaka Kenichi
Department Of Pharmacology Tokyo University Of Pharmacy & Life Science
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Kogo Hiroshi
Department Of Pharmacology Tokyo University Of Pharmacy & Life Science
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