Agonistic-Antagonistic Actions of Clomiphene Citrate on PGF2.ALPHA. Fluctuations in Ovariectomized Rat Uterus.
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概要
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Effects of clomiphene and/or estrogen on uterine prostaglandin (PG) F<SUB>2α</SUB> fluctuations in ovariectomized rats were examined. Uterine PGF<SUB>2α</SUB> fluctuations were measured at the indicated times after injection of clomiphene and/or estradiol. Antiestrogenic effects of clomiphene on urine weight and PGF<SUB>2α</SUB> levels were observed at 6 hr, and its effect on uterine 13, 14-dihydro-15-keto-PGF<SUB>2α</SUB> forming capacity was observed at 24 hr. At 48 and 72 hr, additive effects were recognized in all parameters. These results indicate that clomiphene possesses agonistic-antagonistic actions on the PGF<SUB>2α</SUB> fluctuations in the uterus.
- 公益社団法人 日本薬理学会の論文
著者
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Kogo Hiroshi
Department Of Anatomy And Cell Biology Gunma University School Of Medicine
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Hikikoshi Atsuko
Department of Pharmacology, Tokyo College of Pharmacy
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