Effect of Thyroid Hormone on CYP19 Expression in Ovarian Granulosa Cells From Gonadotropin-Treated Immature Rats
スポンサーリンク
概要
- 論文の詳細を見る
The present study was designed to determine the mechanisms by which serum estradiol levels are enhanced during gonadotropin-induced ovarian development in hypothyroid immature rats. Thyroidectomized (Tx)-immature rats receiving thyroidectomy on day 22 were treated with 8 IU equine chorionic gonadotropin (eCG) at 26 days of age to induce follicular development in ovaries. Ovaries or ovarian granulosa cells were collected on the first proestrus (day 28). Enhanced expression of aromatase (CYP19) mRNA induced by eCG treatment was inhibited by injection of thyroxine (T4: 5 μg × 6 times) in Tx rats. Ovarian granulosa cells harvested from Tx rats were cultured for 24 h in chemically defined serum-free medium containing gonadotropin in the presence of 3,5,3-triidothyronine (T3). Addition of low doses of T3 (10−8, 10−7 M) to the medium significantly decreased 17β-estradiol (E2) levels, whereas high doses of T3 (10−6, 10−5 M) did not inhibit the levels. Similar effects of T3 on CYP19 mRNA expression were observed. These results indicate that augmentation of E2 production in hypothyroid animals may be mediated, in part, via the stimulation of CYP19 mRNA expression in granulosa cells, which is suppressed by thyroid hormone.
- 社団法人 日本薬理学会の論文
- 2004-04-01
著者
-
Kogo Hiroshi
Department Of Anatomy And Cell Biology Gunma University School Of Medicine
-
Toda Katsumi
Department Of Medical Chemistry Kochi Medical School
-
Toda Katsumi
Department Of Molecular Genetics School Of Medicine Kochi University
-
Tamura K
Department Of Endocrine Pharmacology School Of Pharmacy Tokyo University Of Pharmacy & Life Scie
-
Shimizu Yoko
Department Of Endocrine Pharmacology School Of Pharmacy Tokyo University Of Pharmacy & Life Scie
-
Tamura Kazuhiro
Department Of Endocrine Pharmacology Tokyo University Of Pharmacy And Life Science
-
HATSUTA Minoru
Department of Endocrine Pharmacology, School of Pharmacy, Tokyo University of Pharmacy & Life Scienc
-
Kogo Hiroshi
Department Of Endocrine Pharmacology School Of Pharmacy Tokyo University Of Pharmacy & Life Scie
-
Hatsuta Minoru
Department Of Endocrine Pharmacology School Of Pharmacy Tokyo University Of Pharmacy & Life Scie
関連論文
- Temporal Expression of Type I Interferon Receptor in the Peri-Implantation Ovine Extra-Embryonic Membranes : Demonstration that Human IFNα Can Bind to This Receptor
- Co-Expression of Transforming Growth Factor β and Interferon τ During Peri-Implantation Period in the Ewe
- EFFECT OF PREGNANT MARE SERUM GONADOTROPIN AND ESTRADIOL ON THE FORMATION OF 13,14-DIHYDROPROSTAGLANDIN F_ IN RAT OVARY
- Aromatase-deficient (ArKO) mice are retrieved from severe hepatic steatosis by peroxisome proliferator administration
- Sequestration of Cross-linked Membrane Molecules to Caveolae in Two Different Pathways
- Caveolae: from a morphological point of view
- Molecular Mechanism for the Expression of Caveolin-1 Isoforms : Relevance to the Formation of Caveolar Invagination
- Direct Ovarian Effects of a GnRH Agonist in Hypophysectomized Immature Rats : Inhibition of Theca-Interstitial Luteinizing Hormone Receptor mRNA Expression and Induction of Interstitial Cell Differentiation(Reproductive Biology)
- MUTUALLY EXCLUSIVE EXPRESSION OF CAVEOLIN-1 ISOFORMS IN THE DIFFERENT CELL TYPES OF THE MOUSE LUNG(Cell Biology and Morphology,Abstracts of papers presented at the 74^ Annual Meeting of the Zoological Society of Japan)
- A-16 Caveolin-1 and Structure of Caveolae
- Caveolae and Endoplasmic Reticulum : Immunofluorescence Microscopy and Time-Lapse Analysis
- Acousto-Optic Bragg Diffraction by Deep Bulk Acoustic Waves for Use in Optic Spectrum Analyser : Photoacoustic Spectroscopy
- Propagation Characteristics of SAW on a ZnO/SiO_2/high-velocity-substrate Structure : SAW and Communication Devices
- Effect of Surface Electrical Boundary Condition on Temperature Stability of SAW Devices : SAW and Communication Devices
- Accuracy of Gates RF Pulse Measurement : Acoustical Measurements and Instrumentation
- High-Frequency Operation for Resin-Coated BAW Beam Devices : SAW and Communication Devices
- Automated Acousto-Optic Measurement System of Bluk Acoustic Waves Launched from an IDT : Acoustical Measurements and Instrumentation
- Role of BK Channels in Testosterone-Induced Relaxation of the Aorta in Spontaneously Hypertensive Rats(Pharmacology)
- Dexamethasone or Triamcinolone Increases Follicular Development in Immature Female Rats
- Double RF System for Suppression of Longitudinal Coupled Bunch Instability on UVSOR Storage Ring
- Prostaglandin F_ -Induced Functional Regression of the Corpus Luteum and Apoptosis in Rodents
- EFFECT OF 13, 14-DIHYDROPROSTAGLANDIN F2α ON STEROID BIOSYNTHESIS IN RAT OVARY
- EFFECT OF GONADOTROPIN AND ESTROGEN ON CHANGES IN LEVELS OF PROSTAGLANDIN IN RAT OVARY
- Short Term Hypercholesterolemia Alters N^G-Nitro-L-arginine-and Indomethacin-Resistant Endothelium-Dependent Relaxation by Acetylcholine in Rabbit Renal Artery
- SIGNIFICANCE OF GONAD AND RENAL PROSTAGLANDIN E_2 IN THE ANTIHYPERTENSIVE EFFECT OF PINDOLOL IN SPONTANEOUSLY HYPERTENSIVE RATS
- Effect of Etidronate on Aortic Calcification and Bone Metabolism in Calcitoriol-Treated Rats With Subtotal Nephrectomy
- Effects of Phytoestrogens on Acetylcholine- and Isoprenaline-Induced Vasodilation in Rat Aorta
- 17β-Estradiol Alters Isoproterenol-Induced Relaxation in Rat Aortic Rings
- ROLE OF PHOSPHOLIPID IN THE EFFECT OF ESTRADIOL ON SUGAR TRANSPORT IN RAT UTERUS
- EFFECT OF METHYLXANTHINES ON URINARY PROSTAGLANDIN E EXCRETION IN RATS
- EFFECT OF THEOPHYLLINE ON THE RELEASE AND CONTENTS OF PROSTAGLANDINS E AND F IN RAT
- EFFECT OF INTRA-UTERINE ADMINISTRATION OF INDOMETHACIN ON OVARIAN STEROIDS
- EFFECT OF OXYTOCIN AND ESTROGEN ON PROSTACYCLIN RELEASE FROM ISOLATED UTERUS IN OVARIECTOMIZED RATS
- EFFECT OF PHOSPHOLIPASE A, C, AND D ON SUGAR AND AMINO ACID TRANSPORT IN RAT UTERUS
- Developmental changes in soluble proteins during the early development of Dictyostelium discoideum
- THE ROLE OF UTERINE TISSUE IN CHANGES OF PROSTAGLANDIN CONTENT IN THE RAT OVARY
- VIBRATION BEHAVIOR OF ROTATING SHAFT DUE TO CONTACT WITH CASING
- Effect of Thyroid Hormone on CYP19 Expression in Ovarian Granulosa Cells From Gonadotropin-Treated Immature Rats
- Involvement of Stathmin in Proliferation and Differentiation of Immortalized Human Endometrial Stromal Cells
- The Expression of Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) and Its Regulation by Ovarian Steroids in Rat Uterine Stromal Cells
- Influence of OSW-1 [3β, 16β, 17α-Trihydroxycholest-5-en-22-one 16-O-(2-O-4-methoxybenzoyl-β-D-xylopyranosyl)-(1→3)-(2-O-acetyl-α-L-arabinopyranoside)], a Steroidal Saponin, on Endothelium Dependent Relaxation Caused by Acetylcholine in Rat Aorta
- GONADOTROPIN-RELEASING HORMONE RECEPTOR mRNA EXPRESSION IN THE OVARIES OF NEONATAL AND ADULT RATS
- EFFECT OF VASOPRESSIN ON RAT URINARY PROSTAGLANDIN EXCRETION
- Significance of Phospholipid in Estrogen Action on Rat Uterus
- Protease-Activated Receptor-Stimulated Interleukin-6 Expression in Endometriosis-Like Lesions in an Experimental Mouse Model of Endometriosis
- Four supernumerary molars in one maxillary quadrant : A case report
- A Comparison of the Effects of Estradiol and 2- and 4-Hydroxyestradiol on Uterine Ornithine Decarboxylase Activity in Immature Rats.
- Inhibitory effect of acemetacin, a prodrug of indomethacin, on prostaglandin E2 release from inflamed synovial tissue.
- Effects of Antiestrogens on Ovarian Aldo-Keto Reductase in Relation to Ovulation in Rats.
- Effects of Repeated Administration of Pilocarpine and Isoproterenol on Aquaporin-5 Expression in Rat Salivary Glands
- Agonistic-Antagonistic Actions of Clomiphene Citrate on PGF2.ALPHA. Fluctuations in Ovariectomized Rat Uterus.
- The mode of action of indomethacin, aspirin and melatonin on the blockage of the first ovulation in immature rat pretreated with PMSG.
- Kinetics of the oxidation of aqueous sodium sulfite solutions with air.
- The possible role of the pituitary gland and uterine tissue in the production system of 13,14-dihydroprostaglandin F2.ALPHA. in rat ovary.