Prostaglandin F_<2α> -Induced Functional Regression of the Corpus Luteum and Apoptosis in Rodents
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概要
- 論文の詳細を見る
We investigated the relationship between prostaglandin (PG) F2α-induced functional luteal regression and apoptosis in the rodent ovary. Administration of PGF2α significantly decreased the serum levels of progesterone within 12 h after treatment in pseudopregnant mice. Apparent signals were detected in luteal tissues at 24 to 72 h by terminal deoxynucleotidyl transferase (TdT)-mediated dUTP-biotin nick endo labeling (TUNEL) assay. PGF2α significantly increased the levels of the cleavage nuclear poly (ADP-ribose) polymerase fragment and transforming growth factor-β (TGF-β) mRNA within 48 h. PGF2α (10 μM) decreased progesterone secretion 6 to 72 h after its addition in luteinized ovarian cells, whereas C2-ceramide (25 μM) decreased progesterone levels by 44% 72 h after its addition. DNA fragmentation was not observed in the cultured cells treated with PGF2α for 24 h, although cells incubated with C2-ceramide showed fragmentation. Treatment with PGF2α for 1 h caused a distinct decrease in luteinizing hormone (LH)-induced cyclic AMP production. Thus, the inhibitory effect of PGF2α on progesterone secretion may be caused by both the blockage of the functional LH receptor and the activation of apoptotic signaling.
- 社団法人 日本薬理学会の論文
- 2003-05-01
著者
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IMAKAWA Kazuhiko
Laboratory of Animal Breeding, Faculty of Agriculture, The University of Tokyo
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Imakawa Kazuhiko
Laboratory Of Animal Breeding And Reproduction Department Of Veterinary Medical Sciences Graduate Sc
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TAMURA Kazuhiro
Department of Pharmacology, Tokyo University of Pharmacy and Life Science
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KOGO Hiroshi
Department of Pharmacology, Tokyo University of Pharmacy and Life Science
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Kogo H
Department Of Pharmacology Tokyo College Of Pharmacy
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Kogo Hiroshi
東京薬科大学 内分泌分子薬理学
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Kogo Hiroshi
Department Of Electrical Engineering Chiba University
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Kogo H
Deparfment Of Anatomy And Molecular Cell Biology Nagoya University Graduate School Of Medicine
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Kogo Hiroshi
Department Of Anatomy And Cell Biology Gunma University School Of Medicine
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Imakawa K
Univ. Tokyo Tokyo Jpn
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WANG Zhiyan
Department of Pharmacology, Tokyo University of Pharmacy and Life Science
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YOSHIE Mikihiro
Department of Pharmacology, Tokyo University of Pharmacy and Life Science
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TAMURA Hiroshi
Pharmarise Co., Ltd., Nishishinjuku Indensu Kodama Bidg
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Wang Zhiyan
Department Of Pharmacology Tokyo University Of Pharmacy And Life Science
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Tamura Kazuhiro
Department Of Pharmacology Tokyo University Of Pharmacy And Life Science
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Tamura Kazuhiro
Department Of Endocrine Pharmacology Tokyo University Of Pharmacy And Life Science
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Imakawa Kazuhiko
Laboratory Of Animal Breeding Graduate School Of Agricultural And Life Sciences The University Of To
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Tamura Hiroshi
Pharmarise Co. Ltd.
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YOSHIE Mikihiro
Department of Endocrine Pharmacology, Tokyo University of Pharmacy and Life Science
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TAMURA Kazuhiro
Department of Endocrine and Neural Pharmacology, Tokyo University of Pharmacy and Life Sciences, Tokyo 192-0392, Japan
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