EFFECT OF PREGNANT MARE SERUM GONADOTROPIN AND ESTRADIOL ON THE FORMATION OF 13,14-DIHYDROPROSTAGLANDIN F_<2α> IN RAT OVARY
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概要
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Effects of pregnant mare serum gonadotropin (PMS) and estradiol on the formation of 13,14-dihydroprostaglandin F_<2α> (13,14H_2-PGF_<2α>) from prostaglandin F_<2α> (PGF_<2α>) and 13,14-dihydro-15-ketoprostaglandin F_<2α> (15KD-PGF_<2α>) in the ovarian homogenate of rats were examined. PMS and estradiol were given to the rats (s.c.) on the first day of diestrus, and the ovaries were removed 24 hours after treatment with each hormone. PMS stimulated the formation of 13,14H_2-PGF_<2α> from PGF_<2α> and 15KD-PGF_<2α>, and estradiol markedly inhibited the formation of 13,14H_2-PGF_<2α> from PGF_<2α> and 15KD-PGF_<2α>. However, the formation of 15KD-PGF_<2α> from PGF_<2α> did not change with PMS and estradiol. These results indicate that 13,14H_2-PGF_<2α> formed in rat ovary may play some important role in ovarian function and may be regulated by gonadotropins and ovarian steroids.
- 公益社団法人日本薬学会の論文
著者
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Inazu Norihisa
Department Of Pharmacology Tokyo College Of Pharmacy
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KOGO Hiroshi
Department of Pharmacology, Tokyo University of Pharmacy and Life Science
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Kogo Hiroshi
Department Of Pharmacology Tokyo College Of Pharmacy
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Kogo Hiroshi
Department Of Anatomy And Cell Biology Gunma University School Of Medicine
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AIZAWA YOSHIO
Department of Pharmacology, Tokyo College of Pharmacy
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Inazu Norihisa
Department Of Pharmacology And Toxicology Tokyo College Of Pharmacy
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Aizawa Yoshio
Department Of Pharmacology Tokyo College Of Pharmacy
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AIZAWA Yoshio
Department of Pharmacolgy, Tokyo College of Pharmacy
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