SIGNIFICANCE OF GONAD AND RENAL PROSTAGLANDIN E_2 IN THE ANTIHYPERTENSIVE EFFECT OF PINDOLOL IN SPONTANEOUSLY HYPERTENSIVE RATS
スポンサーリンク
概要
- 論文の詳細を見る
The effect of gonadectomy on the antihypertensive action of pindolol in male spontaneously hypertensive rats (SHR) was investigated. And we also examined the relationship between the antihypertensive effect of this drug and the renal prostaglandin E_2 (PGE_2) level. In gonadectomized SHR, the reduction of blood pressure was not observed by the oral administration of pindolol, although the drug exhibited a marked antihypertensive activity in sham operated SHR. Urinary PGE_2 in sham operated SHR was increased following the administration of pindolol, but not in gonadectomized SHR. Similar results were obtained in the experiments using Wistar rats. The PG synthesis inhibition induced by indomethacin suppressed the antihypertensive action of pindolol. Results in the present study suggest that renal PGs, particularly PGE_2,are involved in the antihypertensive mechanism of pindolol, and that male gonad takes part in the regulation of the stimulation of the renal PGE_2 producing system induced by pindolol.
- 公益社団法人日本薬学会の論文
著者
-
Satoh Tetsuo
Department Of Pharmacology And Toxicology Tokyo College Of Pharmacy
-
KOGO Hiroshi
Department of Pharmacology, Tokyo University of Pharmacy and Life Science
-
Kogo H
Department Of Pharmacology Tokyo College Of Pharmacy
-
Kogo Hiroshi
東京薬科大学 内分泌分子薬理学
-
Kogo Hiroshi
Department Of Electrical Engineering Chiba University
-
Kogo H
Deparfment Of Anatomy And Molecular Cell Biology Nagoya University Graduate School Of Medicine
-
Kogo Hiroshi
Department Of Anatomy And Cell Biology Gunma University School Of Medicine
-
Aizawa Y
Nakano Egota Hospital
-
AIZAWA YOSHIO
Nakano Egota Hospital
-
Satoh Tetsuo
Department Of Anesthesiology National Defense Medical College
関連論文
- CHARACTERIZATION AND PURIFICATION OF VARIOUS CARBOXYLESTERASE ISOZYMES FROM RAT LIVER MICROSOME
- THE EFFECTS OF ASPIRIN AND ITS METABOLITE, SALICYLIC ACID, ON CULTURED RAT EMBRYO
- ACETYLSALICYLIC ACID INDUCED FETALTOXICITY AND DRUG METABOLISM
- POTENTIATION OF EPN-INDUCED INHIBITION OF LIVER MICROSOMAL CARBOXYLESTERASE BY NAD IN VITRO
- Temporal Expression of Type I Interferon Receptor in the Peri-Implantation Ovine Extra-Embryonic Membranes : Demonstration that Human IFNα Can Bind to This Receptor
- PHYSIOLOGICAL ROLES OF ALDO/KETO REDUCTASES IN REPRODUCTIVE ORGANS
- LOCALIZATION OF CARBONYL REDUCTASE IN RAT OVARY AND ITS PHYSIOLOGICAL ROLE IN OVARIAN FUNCTION
- CHARACTERISTIC AND PHYSIOLOGICAL ROLES OF CARBONYL REDUCTASES IN RAT OVARY
- CHARACTERISTICS OF 13,14-DIHYDROPROSTAGLANDIN F_ SYNTHETASE OF RAT OVARY
- EFFECT OF PREGNANT MARE SERUM GONADOTROPIN AND ESTRADIOL ON THE FORMATION OF 13,14-DIHYDROPROSTAGLANDIN F_ IN RAT OVARY
- Sequestration of Cross-linked Membrane Molecules to Caveolae in Two Different Pathways
- Caveolae: from a morphological point of view
- Molecular Mechanism for the Expression of Caveolin-1 Isoforms : Relevance to the Formation of Caveolar Invagination
- Direct Ovarian Effects of a GnRH Agonist in Hypophysectomized Immature Rats : Inhibition of Theca-Interstitial Luteinizing Hormone Receptor mRNA Expression and Induction of Interstitial Cell Differentiation(Reproductive Biology)
- MUTUALLY EXCLUSIVE EXPRESSION OF CAVEOLIN-1 ISOFORMS IN THE DIFFERENT CELL TYPES OF THE MOUSE LUNG(Cell Biology and Morphology,Abstracts of papers presented at the 74^ Annual Meeting of the Zoological Society of Japan)
- A-16 Caveolin-1 and Structure of Caveolae
- Caveolae and Endoplasmic Reticulum : Immunofluorescence Microscopy and Time-Lapse Analysis
- Acousto-Optic Bragg Diffraction by Deep Bulk Acoustic Waves for Use in Optic Spectrum Analyser : Photoacoustic Spectroscopy
- Propagation Characteristics of SAW on a ZnO/SiO_2/high-velocity-substrate Structure : SAW and Communication Devices
- Effect of Surface Electrical Boundary Condition on Temperature Stability of SAW Devices : SAW and Communication Devices
- Accuracy of Gates RF Pulse Measurement : Acoustical Measurements and Instrumentation
- High-Frequency Operation for Resin-Coated BAW Beam Devices : SAW and Communication Devices
- Automated Acousto-Optic Measurement System of Bluk Acoustic Waves Launched from an IDT : Acoustical Measurements and Instrumentation
- Role of BK Channels in Testosterone-Induced Relaxation of the Aorta in Spontaneously Hypertensive Rats(Pharmacology)
- REGULATION AND PHYSIOLOGICAL ROLE OF HEPATIC MICROSOMAL CARBOXYLESTERASES
- Dexamethasone or Triamcinolone Increases Follicular Development in Immature Female Rats
- EFFECT OF LIPID PEROXIDATION ON COVALENT BINDING OF ACTIVE METABOLITE OF ACETAMINOPHEN TO LIVER MICROSOMAL MACROMOLECULES IN SEVERAL ANIMAL SPECIES
- PROTECTIVE ROLE OF COMPONENTS IN CELL CYTOSOL AGAINST ACETAMINOPHEN-INDUCED HEPATOTOXICITY (The Fourth Meeting for the Study of Toxic Effect)
- 118. METABOLISM AND HEPATOTOXICITY OF ACETAMINOPHEN (The Third Meeting for the Study of Toxic Effect)
- COMPARISON OF EFFECTS OF ACETAMINOPHEN ON LIVER MICROSOMAL DRUG METABOLISM AND LIPID PEROXIDATION IN RATS AND MICE
- 124. Toxicity of Procaine and Its Brain Concentration (The Second Meeting for the Study of Toxic Effect)
- Prostaglandin F_ -Induced Functional Regression of the Corpus Luteum and Apoptosis in Rodents
- EFFECT OF 13, 14-DIHYDROPROSTAGLANDIN F2α ON STEROID BIOSYNTHESIS IN RAT OVARY
- EFFECT OF GONADOTROPIN AND ESTROGEN ON CHANGES IN LEVELS OF PROSTAGLANDIN IN RAT OVARY
- Short Term Hypercholesterolemia Alters N^G-Nitro-L-arginine-and Indomethacin-Resistant Endothelium-Dependent Relaxation by Acetylcholine in Rabbit Renal Artery
- SIGNIFICANCE OF GONAD AND RENAL PROSTAGLANDIN E_2 IN THE ANTIHYPERTENSIVE EFFECT OF PINDOLOL IN SPONTANEOUSLY HYPERTENSIVE RATS
- Effect of Etidronate on Aortic Calcification and Bone Metabolism in Calcitoriol-Treated Rats With Subtotal Nephrectomy
- Effects of Phytoestrogens on Acetylcholine- and Isoprenaline-Induced Vasodilation in Rat Aorta
- 17β-Estradiol Alters Isoproterenol-Induced Relaxation in Rat Aortic Rings
- ROLE OF PHOSPHOLIPID IN THE EFFECT OF ESTRADIOL ON SUGAR TRANSPORT IN RAT UTERUS
- EFFECT OF METHYLXANTHINES ON URINARY PROSTAGLANDIN E EXCRETION IN RATS
- EFFECT OF THEOPHYLLINE ON THE RELEASE AND CONTENTS OF PROSTAGLANDINS E AND F IN RAT
- EFFECT OF INTRA-UTERINE ADMINISTRATION OF INDOMETHACIN ON OVARIAN STEROIDS
- EFFECT OF OXYTOCIN AND ESTROGEN ON PROSTACYCLIN RELEASE FROM ISOLATED UTERUS IN OVARIECTOMIZED RATS
- EFFECT OF PHOSPHOLIPASE A, C, AND D ON SUGAR AND AMINO ACID TRANSPORT IN RAT UTERUS
- MULTIPLICITY AND FUNCTION OF HEPATIC MICROSOMAL CARBOXYLESTERASES IN VARIOUS MAMMALS AND HUMANS
- MULTIPLICITY AND REGULATION OF HEPATIC MICROSOMAL CARBOXYLESTERASE IN RATS
- Assessment of the lingual tonsil and vallecula during fiberoptic intubation
- Flumazenil reduces the hypnotic dose of propofol in male patients under spinal anesthesia
- Halothane anesthesia decreases the extracellular level of dopamine in rat striatum : a microdialysis study in vivo
- Accidental subdural catheterization suspected on administration of a test dose of lidocaine and successfully managed by a small dose of dibucaine
- NAD-Coupled Enzymatic Oxidation of O-Ethyl O-p-Nitrophenyl Phenylphosphonothioate (EPN) to Its Oxygen Analog with Liver Microsomes of Rats
- THE ROLE OF UTERINE TISSUE IN CHANGES OF PROSTAGLANDIN CONTENT IN THE RAT OVARY
- Terminal deletion of chromosome 10q : Clinical features and literature review
- Propofol injection pain is not alleviated by pretreatment with flurbiprofen axetil, a prodrug of a nonsteroidal antiinflammatory drug
- MULTIPLICITY AND DIFFERENCES IN THE INDUCTION OF HEPATIC MICROSOMAL CARBOXYLESTERASE ISOZYMES IN INBRED STRAINS OF RATS AND MICE
- Effect of Thyroid Hormone on CYP19 Expression in Ovarian Granulosa Cells From Gonadotropin-Treated Immature Rats
- Involvement of Stathmin in Proliferation and Differentiation of Immortalized Human Endometrial Stromal Cells
- The Expression of Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) and Its Regulation by Ovarian Steroids in Rat Uterine Stromal Cells
- Autoantibodies against C-reactive protein (CRP) in sera of patients with systemic rheumatic diseases
- STUDIES ON THE ULTRASTRUCTURAL DISTRIBUTION OF H3-DIMETACRINE IN RAT CEREBRAL CORTEX
- PARTIAL PURIFICATION AND IMMUNOLOGICAL ASPECTS OF CARBOXYLESTERASE FROM RAT LIVER MICROSOMES
- Influence of OSW-1 [3β, 16β, 17α-Trihydroxycholest-5-en-22-one 16-O-(2-O-4-methoxybenzoyl-β-D-xylopyranosyl)-(1→3)-(2-O-acetyl-α-L-arabinopyranoside)], a Steroidal Saponin, on Endothelium Dependent Relaxation Caused by Acetylcholine in Rat Aorta
- GLUTATHIONE DEPLETION BY ANILINE ANALOGS IN VITRO ASSOCIATED WITH LIVER MICROSOMAL CYTOCHROME P-450
- EFFECT OF LYOPHILIZATION AND STORAGE OF LIVER 9, 000 × g SUPERNATANT FRACTION ON THE METABOLISM OF IMIPRAMINE IN SEVERAL SPECIES OF ANIMALS
- GONADOTROPIN-RELEASING HORMONE RECEPTOR mRNA EXPRESSION IN THE OVARIES OF NEONATAL AND ADULT RATS
- EFFECT OF VASOPRESSIN ON RAT URINARY PROSTAGLANDIN EXCRETION
- THE PHARMACOKINETICS OF OCHRATOXIN A IN RATS
- EFFECT OF PRETREATMENT WITH TRICRESYLPHOSPHATES AND PHENOBARBITAL ON THE METABOLISM AND TOXICITY OF PROCAINE IN RATS
- Significance of Phospholipid in Estrogen Action on Rat Uterus
- Comparison of Vasodilation Potency between Sufentanil and Fentanyl on the Isolated Aorta of the Rat
- A Comparison of the Effects of Estradiol and 2- and 4-Hydroxyestradiol on Uterine Ornithine Decarboxylase Activity in Immature Rats.
- Plasma glutathione S-transferase in carbon tetrachrolide treated rats and its association to hepatic cytosolic isozymes.
- Enhancement of the binding of O-ethyl O-p-nitrophenyl phenylphosphonate (EPNoxon) to microsomal carboxylesterase by NAD in vitro.
- Contribution of isosorbide-5-mononitrate, a major metabolite of isosorbide dinitrate (ISDN), to the hemodynamic effect of ISDN administered orally in conscious dogs.
- Inhibitory effect of acemetacin, a prodrug of indomethacin, on prostaglandin E2 release from inflamed synovial tissue.
- Effects of co-administration of monomethylaminoantipyrine and cobaltous chloride on hepatic glutathione level and glutathione-related enzyme activities in rats.
- Effects of Antiestrogens on Ovarian Aldo-Keto Reductase in Relation to Ovulation in Rats.
- Effects of Repeated Administration of Pilocarpine and Isoproterenol on Aquaporin-5 Expression in Rat Salivary Glands
- Agonistic-Antagonistic Actions of Clomiphene Citrate on PGF2.ALPHA. Fluctuations in Ovariectomized Rat Uterus.
- Suppression of pentylenetetrazol-induced seizures by hydralazine associated with 5-hydroxytryptaminergic system in rat brain.
- The mode of action of indomethacin, aspirin and melatonin on the blockage of the first ovulation in immature rat pretreated with PMSG.
- The possible role of the pituitary gland and uterine tissue in the production system of 13,14-dihydroprostaglandin F2.ALPHA. in rat ovary.