Enhancement of the binding of O-ethyl O-p-nitrophenyl phenylphosphonate (EPNoxon) to microsomal carboxylesterase by NAD in vitro.
スポンサーリンク
概要
- 論文の詳細を見る
Inhibition of rat liver microsomal carboxylesterase(CEase) by O-ethyl O-p-nitrophenyl phenylphosphonothioate (EPN) and binding of EPN oxygen analog to microsomal CEase were enhanced by addition of NAD or NADP. This was more prominent in addition of NAD than NADP. No potentiation of anti-CEase action of EPN by NAD was seen when pure esterase (E.C. 3.1.1.1) instead of liver microsomes was used as an enzyme source. This effect of NAD in microsomal CEase was significantly decreased when N-ethylmaleimide or p-chloromercuribenzoic acid was added. From these findings, it is strongly suggested that NAD-mediated potentiation of the anti-CEase action of EPN might be attributed to the increase in formation of NADH from NAD by microsomal dehydrogenase(s) containing a sulfhydryl group, leading to a subsequent increase in formation of the EPN oxygen analog from EPN, and in turn, CEase inhibition was enhanced.
- 公益社団法人 日本薬理学会の論文
著者
-
Igarashi Takashi
Laboratory Of Biochemical Pharmacology And Biotoxicology Faculty Of Pharmaceutical Sciences Chiba Un
-
Ueno Koichi
Laboratory Of Biochemical Pharmacology And Biotoxicology Department Of Drug Evaluation And Toxicolog
-
Satoh Tetsuo
Department Of Anesthesiology National Defense Medical College
-
Hosokawa Masakiyo
Laboratory Of Biochemical Pharmacology And Biotoxicology Faculty Of Pharmaceutical Sciences Chiba Un
-
UENO Koichi
Laboratory of Biochemical Pharmacology and Biotoxicology, Department of Drug Evaluation and Toxicological Sciences, Faculty of Pharmaceutical Scierces, Chiba University
-
SUGIYAMA Seiyu
Laboratory of Biochemical Pharmacology and Biotoxicology, Department of Drug Evaluation and Toxicological Sciences, Faculty of Pharmaceutical Scierces, Chiba University
-
KITAGAWA Haruo
Laboratory of Biochemical Pharmacology and Biotoxicology, Department of Drug Evaluation and Toxicological Sciences, Faculty of Pharmaceutical Scierces, Chiba University
-
KITAGAWA Haruo
Laboratory of Biochemical Pharmacology and Biotoxicology
-
HOSOKAWA Masakiyo
Laboratory of Biochemical Pharmacology and Biotoxicology, Department of Drug Evaluation and Toxicological Sciences, Faculty of Pharmaceutical Scierces, Chiba University
-
UENO Koichi
Laboratory of Biochemical Pharmacology and Biotoxicology
-
IGARASHI Takashi
Laboratory of Biochemical Pharmacology and Biotoxicology, Department of Drug Evaluation and Toxicological Sciences, Faculty of Pharmaceutical Scierces, Chiba University
関連論文
- Expression of histamine H4 receptor in human epidermal tissues and attenuation of experimental pruritus using H4 receptor antagonist
- The structure-activity relationship between oxycoumarin derivatives showing inhibitory effects on iNOS in mouse macrophage RAW264.7 cells
- Enhanced Effect of Connexin 43 on Cisplatin-Induced Cytotoxicity in Mesothelioma Cells
- Establishment and Pathophysiological Characterization of Type 2 Diabetic Mouse Model Produced by Streptozotocin and Nicotinamide(Highlighted paper selected by Editor-in-chief,Pharmacology)
- Comparative study of histamine H4 receptor expression in human dermal fibroblasts
- Expression of Histamine H4 Receptor in Synovial Cells from Rheumatoid Arthritic Patients(Biopharmacy)
- Histamine H4 Receptor Expression in Human Synovial Cells Obtained from Patients Suffering from Rheumatoid Arthritis(Biopharmacy)
- Connexin 32 as an Anti-invasive and Anti-metastatic Gene in Renal Cell Carcinoma
- Cytotoxic Effect of the Her-2/Her-1 Inhibitor PKI-166 on Renal Cancer Cells Expressing the Connexin 32 Gene
- ATTENUATION OF ASPIRIN ANALGESIA BY CALCIUM LOADING IN HEALTHY SUBJECTS
- CHARACTERIZATION AND PURIFICATION OF VARIOUS CARBOXYLESTERASE ISOZYMES FROM RAT LIVER MICROSOME
- NAD-MEDIATED POTENTIATION OF ANTI-CARBOXYLESTERASE ACTION OF EPN (5); PARTICIPATION OF MICROSOMAL DEHYDROGENASE (S)
- IN VIVO INHIBITION OF LIPID PEROXIDE FORMATION BY CLOFIBRATE IN THE RAT
- SPECIES DIFFERENCE IN GLUTATHIONE LEVEL AND GLUTATHIONE RELATED ENZYME ACTIVITIES IN RATS, MICE, GUINEA PIGS AND HAMSTERS
- THE EFFECTS OF ASPIRIN AND ITS METABOLITE, SALICYLIC ACID, ON CULTURED RAT EMBRYO
- INDUCTION OF HEPATIC GLUTATHIONE S-TRANSFERASE ACTIVITIES BY REPEATED ADMINISTRATION OF AMINOPYRINE IN RATS
- PERTURBATION OF HEPATIC GLUTATHIONE LEVEL AND GLUTATHIONE RELATED ENZYME ACTIVITIES BY REPEATED ADMINISTRATION OF AMINOPYRINE IN RATS
- CHANGES OF GAMMA-GLUTAMYLTRANSPEPTIDASE ACTIVITY IN THE RAT DURING DEVELOPMENT AND COMPARISON OF THE FETAL LIVER, PLACENTAL AND ADULT LIVER ENZYMES
- ACETYLSALICYLIC ACID INDUCED FETALTOXICITY AND DRUG METABOLISM
- INDUCTION OF HEPATIC GAMMA-GLUTAMYLTRANSFERASE IN RATS BY LONG-TERM ADMINISTRATION OF AMINOPYRINE
- POTENTIATION OF EPN-INDUCED INHIBITION OF LIVER MICROSOMAL CARBOXYLESTERASE BY NAD IN VITRO
- "P-32 In vitro liver injury model induced by P. acnes-LPS in multicellular sphroids composed of rat liver cells formed by rotary culture system.
- CYTOKINE-DEPENDENT IN VITRO RAT LIVER INJURY INDUCED BY P.ACNES AND LPS.
- CHARACTERISTIC AND PHYSIOLOGICAL ROLES OF CARBONYL REDUCTASES IN RAT OVARY
- CHARACTERISTICS OF 13,14-DIHYDROPROSTAGLANDIN F_ SYNTHETASE OF RAT OVARY
- EFFECTS OF REPEATED DOSES OF COMPOUND E FOR 4 AND 9 WEEKS ON THE MALE REPRODUCTIVE ORGANS (<SPECIAL ISSUE>TESTICULAR TOXICITY)
- EFFECTS OF A DAILY FEEDING-RESTRICTION ON THE REPRODUCTIVE AND DEVELOPMENT TOXICITY PARAMETERS IN FEMALE RATS
- GENERAL PHARMACOLOGICAL STUDIES OF HYDROXYPROPYLMETHYLCELLULOSE ACETATE SUCCINATE IN EXPERIMENTAL ANIMALS
- Induction of Cytochrome P450 1A1 in Mice by Repeated Oral Administration of Propranolol
- EFFECT OF PRENATAL EXPOSURE OF PARATHION ON HUMORAL IMMUNE FUNCTION IN MICE
- BASAL INVESTIGATION ON THE INTRODUCTION OF DRUG METABOLIZING SYSTEM INTO RAT WHOLE EMBBYO CULTURE SYSTEM
- ROLE OF DEHYDROPEPTIDASE-I IN THE METABOLISM OF GLUTATHIONE
- ON THE DIFFERENT FUNCTION OF CYTOCHROME P-450 ISOZYMES IN LIPID PEROXIDATION
- EFFECTS ON OFFSPRING INDUCED BY ORAL ADMINISTRATION OF HYDROXYPROPYLMETHYLCELLULOSE ACETATE SUCCINATE TO THE FEMALE RATS IN PERI-AND POST-NATAL PERIODS
- TERATOLOGICAL STUDY OF HYDROXYPROPYLMETHYLCELLULOSE ACETATE SUCCINATE IN RABBITS
- TERATOLOGICAL STUDIES OF HYDROXYPROPYLMETHYLCELLULOSE ACETATE SUCCINATE IN RATS
- STUDIES OF HYDROXYPROPYLMETHYLCELLULOSE ACETATE SUCCINATE ON FERTILITY IN RATS
- CHARACTERIZATION AND SEX DIFFERENCES OF MEMBRANEBOUND STEROID ESTER HYDROLYZING ENZYMES IN LIVER MICROSOMES OF RATS
- Direct Comparison of Quantized Hall Resistance between Si-MOSFET and GaAs/AlGaAs Heterostructure Devices on the Same Sample Holder
- REGULATION AND PHYSIOLOGICAL ROLE OF HEPATIC MICROSOMAL CARBOXYLESTERASES
- EFFECT OF LIPID PEROXIDATION ON COVALENT BINDING OF ACTIVE METABOLITE OF ACETAMINOPHEN TO LIVER MICROSOMAL MACROMOLECULES IN SEVERAL ANIMAL SPECIES
- PROTECTIVE ROLE OF COMPONENTS IN CELL CYTOSOL AGAINST ACETAMINOPHEN-INDUCED HEPATOTOXICITY (The Fourth Meeting for the Study of Toxic Effect)
- 118. METABOLISM AND HEPATOTOXICITY OF ACETAMINOPHEN (The Third Meeting for the Study of Toxic Effect)
- 329 Productton of Experimental Acute Liver Injury Model Using Multicellular Spheroids Composed of Rat Parenchymal and Non-parenchymal Liver Cells
- Two-Dimensional Electron Gas in an n^+-GaAs/Undoped AlGaAs/Undoped GaAs SIS Structure
- Effect of Nonspecific Binding to Microsomes and Metabolic Elimination of Buprenorphine on the Inhibition of Cytochrome P4502D6(Biochemistry/Molecular Biology)
- Inhibitory effect of the extracts from Thai medicinal plants on iNOS expression in mouse macrophage RAW 264.7
- Inhibitory effect of oxycoumarins isolated from the Thai medicinal plant Clausena guillauminii on the inflammation mediators, iNOS, TNF-α, and COX-2 expression in mouse macrophage RAW 264.7
- Memory and learning-enhancing effect of Daikenchuto, a traditional Japanese herbal medicine, in mice
- Inhibition of the Antibody Production by Acetaminophen Independent of Liver Injury in Mice
- Abatement of Morphine-Induced Slowing in Gastrointestinal Transit by Dai-kenchu-to, a Traditional Japanese Herbal Medicine
- O11-09 Reproductive Immunotoxicity of di-(2-ethyihexyl phthalate(DEHP)in rats
- P-10. Fish micronucleus test using kidney, gill and erythrocytes(Abstracts of the oral and poster presentations)(The 53rd Annual Meeting of the Society of Chromosome Research)
- P-09. Micronucleus test using erythrocytes of Carassius species and Zacco platypus for monitoring genotoxic pollutants in river water(Abstracts of the oral and poster presentations)(The 53rd Annual Meeting of the Society of Chromosome Research)
- PRODUCTION OF EXPERIMENTAL ACUTE LIVER INJURY MODEL USING THE MULTICELLULAR SPHEROIDS COMPOSED OF RAT LIVER CELLS.
- FORMATION AND LONG-TERM CULTURE OF SPHEROID COMPOSED OF LONG-EVANS CINNAMON(LEC)RAT LIVER CELLS
- COMPARISON OF EFFECTS OF ACETAMINOPHEN ON LIVER MICROSOMAL DRUG METABOLISM AND LIPID PEROXIDATION IN RATS AND MICE
- MULTIPLICITY AND CHARACTERIZATION OF GLUTATHIONE STRANSFERASES IN DOG LIVER CYTOSOL
- 124. Toxicity of Procaine and Its Brain Concentration (The Second Meeting for the Study of Toxic Effect)
- A Novel Variant Allele of OATP-C (SLCO1B1) Found in a Japanese Patient with Pravastatin-induced Myopathy
- SIGNIFICANCE OF GONAD AND RENAL PROSTAGLANDIN E_2 IN THE ANTIHYPERTENSIVE EFFECT OF PINDOLOL IN SPONTANEOUSLY HYPERTENSIVE RATS
- MULTIPLICITY AND FUNCTION OF HEPATIC MICROSOMAL CARBOXYLESTERASES IN VARIOUS MAMMALS AND HUMANS
- MULTIPLICITY AND REGULATION OF HEPATIC MICROSOMAL CARBOXYLESTERASE IN RATS
- INFLUENCE OF MATERNAL DRUG METABOLISM ON THE FETAL TOXICITY INDUCED BY ACETYLSALICYLIC ACID
- Assessment of the lingual tonsil and vallecula during fiberoptic intubation
- Flumazenil reduces the hypnotic dose of propofol in male patients under spinal anesthesia
- Halothane anesthesia decreases the extracellular level of dopamine in rat striatum : a microdialysis study in vivo
- Accidental subdural catheterization suspected on administration of a test dose of lidocaine and successfully managed by a small dose of dibucaine
- Structural Organization and Characterization of the Regulatory Element of the Human Carboxylesterase (CES1A1 and CES1A2) genes
- NAD-Coupled Enzymatic Oxidation of O-Ethyl O-p-Nitrophenyl Phenylphosphonothioate (EPN) to Its Oxygen Analog with Liver Microsomes of Rats
- Studies on the Latex Agglutination Inhibition Method for Assay of Plasma Theophylline Concentration
- Terminal deletion of chromosome 10q : Clinical features and literature review
- Propofol injection pain is not alleviated by pretreatment with flurbiprofen axetil, a prodrug of a nonsteroidal antiinflammatory drug
- MULTIPLICITY AND DIFFERENCES IN THE INDUCTION OF HEPATIC MICROSOMAL CARBOXYLESTERASE ISOZYMES IN INBRED STRAINS OF RATS AND MICE
- Weber-Christian disease with benign cytophagic histiocytes in the skin lesion
- HYPOCALCEMIC EFFECT OF ACETYLSALICYLIC ACID IN RATS
- Autoantibodies against C-reactive protein (CRP) in sera of patients with systemic rheumatic diseases
- STUDIES ON THE ULTRASTRUCTURAL DISTRIBUTION OF H3-DIMETACRINE IN RAT CEREBRAL CORTEX
- PARTIAL PURIFICATION AND IMMUNOLOGICAL ASPECTS OF CARBOXYLESTERASE FROM RAT LIVER MICROSOMES
- GLUTATHIONE DEPLETION BY ANILINE ANALOGS IN VITRO ASSOCIATED WITH LIVER MICROSOMAL CYTOCHROME P-450
- EFFECT OF LYOPHILIZATION AND STORAGE OF LIVER 9, 000 × g SUPERNATANT FRACTION ON THE METABOLISM OF IMIPRAMINE IN SEVERAL SPECIES OF ANIMALS
- ASPIRIN INHIBITION OF HYPERCALCEMIC EFFECT OF 1α-HYDROXYVITAMIN D3 IN RATS
- THE PHARMACOKINETICS OF OCHRATOXIN A IN RATS
- EFFECT OF PRETREATMENT WITH TRICRESYLPHOSPHATES AND PHENOBARBITAL ON THE METABOLISM AND TOXICITY OF PROCAINE IN RATS
- A novel animal model of pruritus induced by successive application of glucocorticoid to mouse skin
- Antiallergic Activity of Curcuma longa (II) : Features of inhibitory actions on histamine release from mast cells
- Antiallergic Activity of Curcuma longa (I) : Effectiveness of Extracts Containing Curcuminoids
- Acetaminophen enhances pruritus in a mouse model of contact dermatitis induced by suboptimal concentration of hapten
- The Histamine H_2-Receptor Antagonist, Cimetidine, Inhibits the Articular Osteopenia in Rats With Adjuvant-Induced Arthritis by Suppressing the Osteoclast Differentiation Induced by Histamine
- Comparison of Vasodilation Potency between Sufentanil and Fentanyl on the Isolated Aorta of the Rat
- New 2-Aryl-1,4-naphthoquinone-1-oxime Methyl Ether Compound Induces Microtubule Depolymerization and Subsequent Apoptosis
- Effects of heptaminol AMP amidate on suppressor and helper function of murine T cells.
- Effects of heptaminol AMP amidate(HAA) on cyclic AMP level and mitogen-induced proliferation of murine spleen cells.
- Plasma glutathione S-transferase in carbon tetrachrolide treated rats and its association to hepatic cytosolic isozymes.
- Enhancement of the binding of O-ethyl O-p-nitrophenyl phenylphosphonate (EPNoxon) to microsomal carboxylesterase by NAD in vitro.
- Effect of heptaminol AMP amidate, a new nucleotide derivative, on in vitro humoral immunity.
- Contribution of isosorbide-5-mononitrate, a major metabolite of isosorbide dinitrate (ISDN), to the hemodynamic effect of ISDN administered orally in conscious dogs.
- Effects of co-administration of monomethylaminoantipyrine and cobaltous chloride on hepatic glutathione level and glutathione-related enzyme activities in rats.
- Potentiation of EPN-induced inhibition of liver microsomal carboxylesterase by addition of liver cytosol from 6-aminonicotinamide-treated, starved rats.
- Suppression of pentylenetetrazol-induced seizures by hydralazine associated with 5-hydroxytryptaminergic system in rat brain.