NAD-Coupled Enzymatic Oxidation of O-Ethyl O-p-Nitrophenyl Phenylphosphonothioate (EPN) to Its Oxygen Analog with Liver Microsomes of Rats
スポンサーリンク
概要
- 論文の詳細を見る
-O-Ethyl O-p-nitrophenyl phenylphosphonothioate (EPN)-induced inhibition of rat liver microsomal carboxylesterase (CEase) and formation of O-ethyl O-p-nitrophenyl phenylphosphonate (EPNoxon), an oxygen analog of EPN, were enhanced remarkably by addition of NAD in vitro. This potentiation of the anti-CEase action of EPN by NAD was significantly inhibited by addition of SKF 525-A or potassium thiocyanate (KSCN); and a simultaneous decrease in cytochrome P-450 contents was also observed. Addition of N-ethylmaleimide (NEM) at various concentrations inhibited potentiation of the anti-CEase action of EPN by NAD in parallel with inhibition of liver microsomall dehydrogenase activities. In conclusion, NAD was enzymatically reduced to NADH, a cofactor of microsomal dehydrogenase(s), and then formation of EPNoxon through microsomal cytochrome P-450-coupled monooxygenase was accelerated. Consequently, inhibition of CEase by EPN was potentiated.
著者
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Igarashi Takashi
Laboratory Of Biochemical Pharmacology And Biotoxicology Faculty Of Pharmaceutical Sciences Chiba Un
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Ueno Koichi
Laboratory Of Biochemical Pharmacology And Biotoxicology Department Of Drug Evaluation And Toxicolog
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Satoh Tetsuo
Department Of Anesthesiology National Defense Medical College
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SUGIYAMA Seiyu
Laboratory of Biochemical Pharmacology and Biotoxicology, Department of Drug Evaluation and Toxicological Sciences, Faculty of Pharmaceutical Scierces, Chiba University
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SUGIYAMA Seiyu
Laboratory of Biochemical Pharmacology and Biotoxicology, Department of Drug Fvaluation and Toxicological Sciences, Faculty of Pharmaceutical Sciences, Chiba University
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KITAGAWA Haruo
Laboratory of Biochemical Pharmacology and Biotoxicology
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KITAGAWA Haruo
Laboratory of Biochemical Pharmacology and Biotoxicology, Department of Drug Fvaluation and Toxicological Sciences, Faculty of Pharmaceutical Sciences, Chiba University
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SATOH Tetsuo
Department of Pharmacology, Tokyo College of Pharmacy
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UENO Koichi
Laboratory of Biochemical Pharmacology and Biotoxicology
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UENO Koichi
Laboratory of Biochemical Pharmacology and Biotoxicology, Department of Drug Fvaluation and Toxicological Sciences, Faculty of Pharmaceutical Sciences, Chiba University
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IGARASHI Takashi
Laboratory of Biochemical Pharmacology and Biotoxicology, Department of Drug Fvaluation and Toxicological Sciences, Faculty of Pharmaceutical Sciences, Chiba University
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