EFFECT OF GONADOTROPIN AND ESTROGEN ON CHANGES IN LEVELS OF PROSTAGLANDIN IN RAT OVARY
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概要
- 論文の詳細を見る
Effects of gonadotropin and estrogen on the levels of prostaglandin (PG) in the rat ovary were investigated. PGF content in rat ovary, as measured by radioimmunoassay, was slightly higher than that by bioassay using rat stomach fundus, although there was no statistically significant difference. PGE and PGF levels in rat ovary during the estrous cycle were lowest on the day of diestrus, PGE was of the highest level on the day of estrus, and PGF on the day of proestrus. Both PGE and PGF were increased 24 hours after treatment with pregnant mare serum gonadotropin on the first day of diestrus. PGE was increased about 2.5 fold and PGF about 2.3 fold. PGF was significantly increased 24 hours after treament with estradiol on the first day of diestrus. These results suggest that gonadotropin may directly or indirectly regulate changes in ovarian PG content <I>via</I> actions of estrogen.
- 社団法人 日本薬理学会の論文
著者
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Inazu Norihisa
Department Of Pharmacology Tokyo College Of Pharmacy
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KOGO Hiroshi
Department of Pharmacology, Tokyo University of Pharmacy and Life Science
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Kogo Hiroshi
Department Of Pharmacology Tokyo College Of Pharmacy
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Kogo Hiroshi
Department Of Anatomy And Cell Biology Gunma University School Of Medicine
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AIZAWA YOSHIO
Department of Pharmacology, Tokyo College of Pharmacy
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Inazu Norihisa
Department Of Pharmacology And Toxicology Tokyo College Of Pharmacy
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Aizawa Yoshio
Department Of Pharmacology Tokyo College Of Pharmacy
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AIZAWA Yoshio
Department of Pharmacolgy, Tokyo College of Pharmacy
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