COMPARISON OF EFFECTS OF ACETAMINOPHEN ON LIVER MICROSOMAL DRUG METABOLISM AND LIPID PEROXIDATION IN RATS AND MICE
スポンサーリンク
概要
- 論文の詳細を見る
Studies were conducted to determine the <I>in vivo</I> effect of acetaminophen (AAP) on the lipid peroxidation, drug metabolizing enzyme activity and microsomal electron transfer system of rat and mouse liver. AAP was found to inhibit ethylmorphine N-demethylase activity in the presence of NADPH and this inhibition of the enzyme was due to decrease in cytochrome P-450 content, but not due to change in lipid peroxidation in liver microsomes. Kinetical data showed that AAP administration had no effect on Km values of ethylmorphine N-demethylase, however, a decrease in the Vmax values was seen in rats and mice. There was no significant effect of AAP on both NADPH-cytochrome <I>c</I> reductase and the content of cytochrome <I>b</I><SUB>5</SUB> 3 hours after this administration to rats and mice. On the other hand, AAP induced a significant decrease in NADH-ferricyanide reductase in mice, but not in rats. The greatest decrease in cytochrome P-450 was observed among the components of the liver microsomal electron transfer system of rats and mice.
- 社団法人 日本薬理学会の論文
著者
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Satoh Tetsuo
Department Of Pharmacology And Toxicology Tokyo College Of Pharmacy
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KITAGAWA HARUO
Department of Drug Evaluation and Toxicological Sciences, Faculty of Pharmaceutical Sciences, Chiba
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Kitagawa Haruo
Department Of Biochemical Pharmacology Faculty Of Pharmaceutical Sciences Chiba University
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AIKAWA KAZUO
Department of Biochemical Pharmacology, Faculty of Pharmaceutical Sciences, Chiba University
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Satoh Tetsuo
Department Of Biochemical Pharmacology Faculty Of Pharmaceutical Sciences Chiba University
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Aikawa Kazuo
Department Of Biochemical Pharmacology Faculty Of Pharmaceutical Sciences Chiba University
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Satoh Tetsuo
Department Of Anesthesiology National Defense Medical College
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KITAGAWA Haruo
Department of Biochemical Pharmacology and Biotoxicology, Faculty of Pharmaceutical Sciences, Chiba University
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