THE INVOLVEMENT OF CYTOCHROME P-448 AND P-450 IN NADH-DEPENDENT O-DEMETHYLATION OF <I>p</I>-NITROANISOLE IN RAT LIVER MICROSOMES
スポンサーリンク
概要
- 論文の詳細を見る
These studies have shown that addition of <I>p</I>-nitroanisole to a reaction mixture containing rat liver microsomes resulted in an increase the reoxidation rate of NADH-reduced cytochrome b<SUB>5</SUB>. Fortification of rat liver microsomes with partially purified cytochrome b<SUB>5</SUB> produces an increase in both NADPH-dependent and NADH-dependent <I>p</I>-nitroanisole O-demethylation activity. Antiserum to cytochrome P-450 isolated from phenobarbital-treated rat liver microsomes inhibited the NADH-dependent O-demethylation activity as well as the NADPH-dependent O-demethylation activity seen in rat liver microsomes. Addition of either purified cytochrome P-450 or cytochrome P-448 to an incubation mixture containing phenobarbital-treated rat liver microsomes enhanced the NADH-dependent <I>p</I>-nitroanisole O-demethylation activity. These results suggest that NADH-dependent and, in part, NADPH-dependent O-demethylations are catalyzed by cytochrome P-448 and cytochrome P-450 receiving electrons from cytochrome b<SUB>5</SUB>.
- 社団法人 日本薬理学会の論文
著者
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KAMATAKI TETSUYA
Department of Pharmacology, School of Medicine, Keio University
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KITAGAWA HARUO
Department of Drug Evaluation and Toxicological Sciences, Faculty of Pharmaceutical Sciences, Chiba
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Kamataki Tetsuya
Department Of Biochemical Pharmacology Faculty Of Pharmaceutical Sciences Chiba University
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KITADA MITSUKAZU
Department of Biochemical Pharmacology, Faculty of Pharmaceutical Sciences, Chiba University
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Kitada Mitsukazu
Department Of Biochemical Pharmacology Faculty Of Pharmaceutical Sciences Chiba University
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Kitagawa Haruo
Department Of Biochemical Pharmacology Faculty Of Pharmaceutical Sciences Chiba University
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SHIGEMATSU Hidenari
Department of Hygienic Chemistry, Daiichi College of Pharmacy
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Shigematsu Hidenari
Department Of Hygienic Chemistry Daiichi University Of Pharmaceutical Sciences
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KITAGAWA Haruo
Department of Biochemical Pharmacology, Faculty of Pharmaceutical Sciences, Chiba University
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KITAGAWA Haruo
Department of Biochemical Pharmacology and Biotoxicology, Faculty of Pharmaceutical Sciences, Chiba University
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KAMATAKI Tetsuya
Department of Analytical Bio chemistry, School of Pharmacy, Hokkaido University
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