METABOLIC STUDIES ON METIAZINIC ACID I ABSORPTION, DISTRIBUTION, EXCRETION AND METABOLISM IN RATS AND RABBITS
スポンサーリンク
概要
- 論文の詳細を見る
Absorption, distribution, excretion and metabolism after oral administration of <SUP>3</SUP>H-labelled metiazinic acid were studied. The administrered radioactivity was excreted through both the urinary and fecal routes. The maximum levels of concentration in blood and most tissues were shown within 3 hr after dosing. The highest radioactivity was found in the kidney throughout all experiments. Relatively high radioactivity was observed in inflammatory-treated parts in rats. Unchanged compound, metiazinic acid S-oxide and these conjugates were found in urine and feces. Approximately 60% of the unchanged form was observed in plasma after 6 hr.
- 社団法人 日本薬理学会の論文
著者
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SATOH Hisashi
Department of Dentistry and Oral Surgery, National University Corporation, Hirosaki University Schoo
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KITAGAWA HARUO
Department of Drug Evaluation and Toxicological Sciences, Faculty of Pharmaceutical Sciences, Chiba
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Nanbo Toshio
Tokai Laboratories Daiichi Pure Chemicals Co. Ltd.
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Kitagawa Haruo
Department Of Biochemical Pharmacology Faculty Of Pharmaceutical Sciences Chiba University
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YOKOSHIMA TETSUYOSHI
Tokai Laboratories, Daiichi Pure Chemicals Co., Ltd.
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MIYAZU Kaoru
Department of Biochemical Pharmacology, Faculty of Pharmaceutical Sciences University of Chiba
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TSURUTA Minoru
Department of Biochemical Pharmacology, Faculty of Pharmaceutical Sciences University of Chiba
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TAKEMOTO Minoru
Tokai Laboratory Dai-ichi Pure Chemicals Co., Ltd
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USHIODA Koji
Tokai Laboratory Dai-ichi Pure Chemicals Co., Ltd
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HASEGAWA Masaru
Tokai Laboratory Dai-ichi Pure Chemicals Co., Ltd
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Satoh Hisashi
Department Of Biology Faculty Of Science Kyushu University
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Yokoshima Tetsuyoshi
Tokai Laboratories Daiichi Pure Chemicals Co. Ltd.
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NANBO Toshio
Tokai Laboratory Dai-ichi Pure Chemicals Co., Ltd
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YOKOSHIMA Tetsuyoshi
Tokai Laboratory Dai-ichi Pure Chemicals Co., Ltd
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SATOH Hisashi
Department of Biochemical Pharmacology, Faculty of Pharmaceutical Sciences University of Chiba
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KITAGAWA Haruo
Department of Biochemical Pharmacology and Biotoxicology, Faculty of Pharmaceutical Sciences, Chiba University
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