ENHANCEMENT OF NADPH-DEPENDENT LIPID PEROXIDATION ACTIVITY BY ETHYLENE-DIAMINETETRAACETIC ACID (EDTA) IN THE PRESENCE OF FERROUS ION IN RABBIT LIVER MICROSOMES
スポンサーリンク
概要
- 論文の詳細を見る
The addition of EDTA to the incubation mixture containing rabbit liver microsomes and ferrous ion resulted in 2-fold increase of lipid peroxidation activity. Such an enhancement was not observed in rat liver microsomes. The maximum lipid peroxidation activity seen in rabbit microsomes in the presence of EDTA and ferrous ion was about 80% that seen in rat liver microsomes. From these results, it is likely that low lipid peroxidation activity in rabbit liver microsomes may account for the insufficiency of an EDTA-like factor(s) in rabbit liver microsomes.
- 社団法人 日本薬理学会の論文
著者
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KAMATAKI TETSUYA
Department of Pharmacology, School of Medicine, Keio University
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KITAGAWA HARUO
Department of Drug Evaluation and Toxicological Sciences, Faculty of Pharmaceutical Sciences, Chiba
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Kamataki Tetsuya
Department Of Biochemical Pharmacology Faculty Of Pharmaceutical Sciences Chiba University
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KITADA MITSUKAZU
Department of Biochemical Pharmacology, Faculty of Pharmaceutical Sciences, Chiba University
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Kitada Mitsukazu
Department Of Biochemical Pharmacology Faculty Of Pharmaceutical Sciences Chiba University
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Kitagawa Haruo
Department Of Biochemical Pharmacology Faculty Of Pharmaceutical Sciences Chiba University
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KAMATAKI Tetsuya
Department of Biochemical Pharmacology, Faculty of Pharmaceutical Sciences, Chiba University
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KITAGAWA Haruo
Department of Biochemical Pharmacology and Biotoxicology, Faculty of Pharmaceutical Sciences, Chiba University
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KAMATAKI Tetsuya
Department of Analytical Bio chemistry, School of Pharmacy, Hokkaido University
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