Inhibition by cyanide of drug oxidations in rat liver microsomes.
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概要
- 論文の詳細を見る
Cyanide inhibited microsomal activities of aniline hydroxylation and aminopyrine, ethylmorphine and codeine demethylations and produced a modified type II difference spectrum of cytochrome P-450 to give two spectral dissociation constants, 0.21 mM and 1.05 mM. The binding of cyanide to cytochrome P-450 resulted in inhibition of NADPH-cytochrome P-450 reductase activity. The cyanide inhibition of drug oxidations was partially avoided by increasing oxygen tension. A possible mechanism for the inhibition of drug oxidations by cyanide is discussed.
- 公益社団法人 日本薬理学会の論文
著者
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Kamataki Tetsuya
Department Of Biochemical Pharmacology Faculty Of Pharmaceutical Sciences Chiba University
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Kitada Mitsukazu
Department Of Biochemical Pharmacology Faculty Of Pharmaceutical Sciences Chiba University
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Chiba Kan
Department Of Clinical Pharmacology Research Institute International Medical Center Of Japan
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Kitagawa Haruo
Department Of Biochemical Pharmacology Faculty Of Pharmaceutical Sciences Chiba University
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CHIBA Kan
Department of Biochemical Pharmacology, Faculty of Pharmaceutical Sciences, Chiba University
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KITAGAWA Haruo
Department of Biochemical Pharmacology and Biotoxicology, Faculty of Pharmaceutical Sciences, Chiba University
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KAMATAKI Tetsuya
Department of Analytical Bio chemistry, School of Pharmacy, Hokkaido University
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