EFFECT OF LYOPHILIZATION AND STORAGE OF LIVER 9, 000 × g SUPERNATANT FRACTION ON THE METABOLISM OF IMIPRAMINE IN SEVERAL SPECIES OF ANIMALS
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概要
- 論文の詳細を見る
Effects of lyophilization and storage of liver 9, 000 × g supernatant fraction on the activity of drug metabolizing enzymes in some species of animals were studied. Imipramine metabolizing enzyme activity and the content of cytochrome P-450 were stable for, at least, one month without any loss of the activity when lyophilized liver 9, 000×g supernatant fraction of some animal species, i.e., rat, mouse, guinea pig, rabbit and dog, was stored under reduced pressure in a deep freezer (-20°C). There were no differences of imipramine metabolism between lyophilized liver 9, 000 × g supernatant fraction which was kept in a deep freezer for one month and a fresh fraction which was prepared immediately before determinations of the enzyme activity and cytochrome P-450. The data presented here indicated that the lyophilized preparation of the liver 9, 000 × g supernatant as well as the fresh preparation can be used for the determination of the drug metabolizing enzyme activity.
- 社団法人 日本薬理学会の論文
著者
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Kitagawa Haruo
Department Of Biochemical Pharmacology Faculty Of Pharmaceutical Sciences Chiba University
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Aikawa Kazuo
Department Of Biochemical Pharmacology Faculty Of Pharmaceutical Sciences Chiba University
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Satoh Tetsuo
Department Of Anesthesiology National Defense Medical College
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KODAMA Toshiaki
Department of Biochemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Chiba
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SATOH Tetsuo
Department of Biochemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Chiba
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KITAGAWA Haruo
Department of Biochemical Pharmacology and Biotoxicology, Faculty of Pharmaceutical Sciences, Chiba University
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