EFFECTS OF DIIOSPROPYL-1, 3-DITHIOL-2-YLIDENE MALONATE (NKK-105) ON ACUTE TOXICITY OF VARIOUS DRUGS AND HEAVY METALS.
スポンサーリンク
概要
- 論文の詳細を見る
The influence of NKK-105 on the acute toxicity of strychnine nitrate, potassium cyanide, chloral hydrate, atropine, tetrodotoxin, mercuric chloride, cadmium chloride, lead acetate and arsenic trioxide were examined in rats. NKK-105 prolonged the time of death induced by strychnine, potassium cyanide and tetrodotoxin in acute toxicity. Survival time was prolonged in rats treated with the toxic metals by pretreatment with NKK-105. NKK-105 counteracted the lethal effect of strychnine, potassium cyanide, chloral hydrate, mercuric chloride and cadmium chloride. NKK-105 significantly decreased the acute toxicity of these drugs but the inhibitory effect was not observed in the acute toxicity of atropine, tetrodotoxin, lead acetate and arsenic trioxide.
- 日本トキシコロジー学会の論文
- 1982-06-25
著者
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SAITO Haruo
Department of Radiological Technology, School of Health Sciences, Faculty of Medicine
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YANAURA Saizo
Department of Pharmacology, School of Pharmacy, Hoshi University
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KITAGAWA HARUO
Department of Drug Evaluation and Toxicological Sciences, Faculty of Pharmaceutical Sciences, Chiba
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Saito Haruo
Department Of Pharmaceutical Research Lead Chemical Co. Ltd.
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HOSOKAWA Tomokazu
Department of Pharmacology, School of Pharmacy, Hoshi University
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Hosokawa Tomokazu
Department Of Pharmacology Hoshi College Of Pharmacy
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Kitagawa Haruo
Department Of Biochemical Pharmacology Faculty Of Pharmaceutical Sciences Chiba University
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Kitagawa Haruo
Department Of Drug Evaluation And Toxicological Sciences Faculty Of Pharmaceutical Sciences Chiba Un
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KITAGAWA HARUMI
Department of Pharmacology, School of Pharmacy
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SUGIMOTO Tatsuyoshi
Department of Drug Evaluation and Toxicological Sciences, Faculty of Pharmaceutical Sciences, Chiba
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SAKAMOTO Koji
Department of Pharmacology, School of Medicine, Showa University
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Yanaura Saizo
Department Of Pharmacology Hoshi College Of Pharmacy
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Sugimoto Tatsuyoshi
Department Of Drug Evaluation And Toxicological Sciences Faculty Of Pharmaceutical Sciences Chiba Un
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Sakamoto Koji
Department Of Pharmacology School Of Medicine Showa University
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Yanaura Saizo
Department Of Applied Pharmacology School Of Pharmacy Hoshi University
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Saito Haruo
Department Of Drug Evaluation And Toxicological Sciences Faculty Of Pharmaceutical Sciences Chiba Un
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Hukuhara T
Jikei Univ. School Of Medicine Tokyo
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Hosokawa Tomokazu
Department of Medicinal Plant Sciences, Hoshi University
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Hosokawa Tomokazu
Department of Medicinal Plant Science, Hoshi University
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KITAGAWA Harumi
Department of Pharmacology, Hoshi College of Pharmacy
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KITAGAWA Haruo
Department of Biochemical Pharmacology and Biotoxicology, Faculty of Pharmaceutical Sciences, Chiba University
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YANAURA Saizo
Department of Applied Pharmacology, School of Pharmacy, Hoshi University:Research Institute of Nippon Chemiphar, Co., Ltd.
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