THE PHARMACOKINETICS OF OCHRATOXIN A IN RATS
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概要
- 論文の詳細を見る
The absorption and tissue distribution of ochratoxin A (OCT A) following a single oral dose of OCT A were investigated in adult, male Wistar rats. In experiments concerning excretory patterns of OCT A, <SUP>14</SUP>C-OCT A was used. A relatively large amount of OCT A was found in the circulating blood 48 hours after dosing. The patterns of absorption, tissue distribution and excretion of OCT A were affected by acute catarrhal enteritis produced by OCT A and/or ochratoxin a (OCT α). Quantitative data show that OCT A is distributed mostly in the kidney and this finding is closely associated with the tissue specifity of OCT A-induced nephrotoxicity. OCT A was found to be hydrolyzed to its major metabolite, OCT α by addition of the homogenate of pancreas, duodenum and ileum. Approximately 56% of OCT A administered was excreted in both urine and feces as the unchanged toxin and OCT α during 120 hours following dosing. A relatively larger amount of OCT α was detected as compared with that of OCT A.
- 社団法人 日本薬理学会の論文
著者
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Suzuki Shigetoshi
Research Institute For Chemobiodynamics Chiba University
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YAMAZAKI MIKIO
Research Institute for Chemobiodynamics, Chiba University
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Satoh Tetsuo
Department Of Anesthesiology National Defense Medical College
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Yamazaki Mikio
Research Institute For Chembiodynamics Chiba University
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