ABNORMAL BEHAVIORAL EFFECTS ELICITED BY A NEUROTROPIC MYCOTOXIN, FUMITREMORGIN A IN MICE

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概要

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• Fumitremorgin A (FTA), a neurotropic mycotoxin induced dose-dependent abnormal behaviors, including tremor, clonic convulsion, kangaroo posture and tonic exensor convulsion in the mouse. FTA-induced tinic extensor convulsion was markedly suppressed by anticonvulsant, e.g. phenobarbital, phenytoin. Phenobarbital, trimethadione, valproic acid and mephenesin decreased the occurrence of abnormal behaviors induced by FTA. Although pentylenetetrazol-induced tonic extensor convulsion was not affected by antipsychotic drugs (dopaminergic drugs) except chlorpromazine, FTA-induced abnormal behaviors were inhibited by antipsychotic drugs, e.g. chlorpromazine, haloperidol. Chlordiazepoxide, diazepam and muscimol inhibited FTA-induced abnormal behaviors. These findings suggest that both dopaminergic and γ-aminobutyric acid (GABA)-ergic systems are involved in FTA-induced abnormal behaviors. FTA-induced abnormal behaviors may be useful as a common experimental model for the primary evaluation of anticonvulsants, antipsychotic drugs and anxiolytic drugs.

• 公益社団法人日本薬学会の論文

著者

• Suzuki S

  Research Institute For Chemobiodynamics Chiba University

• Suzuki Shigetoshi

  Research Institute For Chemobiodynamics Chiba University

• Kikkawa Kohei

  Research Institute For Chemobiodynamics Chiba University

• Yamazaki M

  Chiba Univ.

• YAMAZAKI MIKIO

  Research Institute for Chemobiodynamics, Chiba University

• Yamazaki Mikio

  Research Institute For Chembiodynamics Chiba University

関連論文

• NEUROTOXICAL STUDIES ON FUMITREMORGIN A, A TREMORGENIC MYCOTOXIN, ON MICE
• ABNORMAL BEHAVIORAL EFFECTS ELICITED BY A NEUROTROPIC MYCOTOXIN, FUMITREMORGIN A IN MICE
• BIOCHEMICAL INVESTIGATION ON THE ABNORMAL BEHAVIORS INDUCED BY FUMITREMORGIN A, A TREMORGENIC MYCOTOXIN TO MICE
• THE PHARMACOKINETICS OF OCHRATOXIN A IN RATS

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