BIOCHEMICAL INVESTIGATION ON THE ABNORMAL BEHAVIORS INDUCED BY FUMITREMORGIN A, A TREMORGENIC MYCOTOXIN TO MICE

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概要

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• The relationships between behavioral responses and levels of serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) in brain of mice were investigated after intravenous injection of fumitremorgin A (FTA). The latent periods to the onset of tremor, clonic convulsion, tonic convulsion and death induced by FTA are observed in a dose-dependent fashion. However, the dose-dependency is not observed between levels of 5-HT and 5-HIAA and activities of 5-HT metabolizing enzymes in brain of FTA-treated mice. Insignificant participation of serotonergic mechanism in modulation of those behavioral states elicited by FTA is conclusively suggested.

• 公益社団法人日本薬学会の論文

著者

• Suzuki Shigetoshi

  Research Institute For Chemobiodynamics Chiba University

• YAMAZAKI MIKIO

  Research Institute for Chemobiodynamics, Chiba University

• Ozaki Naoko

  (present Address) Department Of Pharmacology Kanazawa Medical University

• Yamazaki Mikio

  Research Institute For Chembiodynamics Chiba University

関連論文

• NEUROTOXICAL STUDIES ON FUMITREMORGIN A, A TREMORGENIC MYCOTOXIN, ON MICE
• ABNORMAL BEHAVIORAL EFFECTS ELICITED BY A NEUROTROPIC MYCOTOXIN, FUMITREMORGIN A IN MICE
• BIOCHEMICAL INVESTIGATION ON THE ABNORMAL BEHAVIORS INDUCED BY FUMITREMORGIN A, A TREMORGENIC MYCOTOXIN TO MICE
• THE PHARMACOKINETICS OF OCHRATOXIN A IN RATS

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