EFFECT OF LIPID PEROXIDATION ON COVALENT BINDING OF ACTIVE METABOLITE OF ACETAMINOPHEN TO LIVER MICROSOMAL MACROMOLECULES IN SEVERAL ANIMAL SPECIES
スポンサーリンク
概要
- 論文の詳細を見る
There was good correlation of lipid peroxidation and covalent binding of acetaminophen (AAP) to liver microsomal protein in mice, guinea pigs and rabbits, but not in rats. By increasing concentrations of EDTA which is an inhibitor of lipid peroxidation, the degree of microsomal lipid peroxidation decreased in mice, guinea pigs, rabbits and rats, and the amount of covalent binding of AAP metabolite to liver microsomal protein increased in mice, guinea pigs and rabbits, but no consistent results were observed in rats. GSH depletion caused by AAP metabolite was increased in accordance with increase in the concentration of EDTA in mice and rats. In rats, the metabolism of AAP increased with increasing concentrations of EDTA and, in contrast to liver microsomes, the radioactivity of enzyme-mediated ^<14>C-AAP metabolite in liver microsomal lipid was not observed. These results indicated that the decrease in covalent binding for AAP metabolite to liver microsomal protein with increasing concentrations of EDTA was not due to the decrease in the amount of AAP metabolite and the binding of ^<14>C-AAP metabolite to liver microsomal lipid layer.
- 公益社団法人日本薬学会の論文
著者
-
Satoh Tetsuo
Department Of Pharmacology And Toxicology Tokyo College Of Pharmacy
-
KOBAYASHI Keiko
Department of Geriatric and Environmental Dermatology, Nagoya City University Graduate School of Med
-
KITAGAWA HARUO
Department of Drug Evaluation and Toxicological Sciences, Faculty of Pharmaceutical Sciences, Chiba
-
Kitagawa Haruo
Department Of Biochemical Pharmacology Faculty Of Pharmaceutical Sciences Chiba University
-
Kobayashi Keiko
Department Of Biochemical Pharmacology Faculty Of Pharmaceutical Sciences Chiba University
-
AIKAWA KAZUO
Department of Biochemical Pharmacology, Faculty of Pharmaceutical Sciences, Chiba University
-
Satoh Tetsuo
Department Of Biochemical Pharmacology Faculty Of Pharmaceutical Sciences Chiba University
-
Aikawa Kazuo
Department Of Biochemical Pharmacology Faculty Of Pharmaceutical Sciences Chiba University
-
Satoh Tetsuo
Department Of Anesthesiology National Defense Medical College
-
KITAGAWA Haruo
Department of Biochemical Pharmacology, Faculty of Pharmaceutical Sciences, Chiba University
-
KITAGAWA Haruo
Department of Biochemical Pharmacology and Biotoxicology, Faculty of Pharmaceutical Sciences, Chiba University
関連論文
- Successful treatment with topical tacrolimus in four cases of discoid lupus erythematosus
- Analyses of the transglutaminase 1 gene mutation and ultrastructural characteristics in a Japanese patient with lamellar ichthyosis
- Caldecrin Is a Novel-Type Serine Protease Expressed in Pancreas, but Its Homologue, Elastase IV, Is and Artifact during Cloning Derived from Caldecrin Gene^1
- Fasting-induced reduction in locomotor activity and reduced response of orexin neurons in carnitine-deficient mice
- Conventional Diet Therapy for Hyperammonemia is Risky in the Treatment of Hepatic Encephalopathy Associated with Citrin Deficiency
- Metabolic derangements in deficiency of citrin, a liver-type mitochondrial aspartate-glutamate carrier
- Risk of Worsened Encephalopathy after Intravenous Glycerol Therapy in Patients with Adult-onset Type II Citrullinemia (CTLN2)
- Hepatocellular Carcinoma in a Case of Adult-onset Type II Citrullinemia
- Expression and Subcellular Localization of Candida tropicalis Catalase in Catalase Gene Disruptants of Saccharomyces cerevisiae
- Individual Expression of Candida tropicalis Peroxisomal and Mitochondrial Carnitine Acetyltransferase-Encoding Genes and Subcellular Localization of the Products in Saccharomyces cerevisiae
- P-137 Cyclohaliclonamines and Phormidinines, Novel 3-Alkylpyridinium and 2-Alkylpyridine Alkaloids from Marine Organisms
- Spongiacysteine, a Novel Cysteine Derivative from Marine Sponge Spongia sp
- ATTENUATION OF ASPIRIN ANALGESIA BY CALCIUM LOADING IN HEALTHY SUBJECTS
- CHARACTERIZATION AND PURIFICATION OF VARIOUS CARBOXYLESTERASE ISOZYMES FROM RAT LIVER MICROSOME
- THE EFFECTS OF ASPIRIN AND ITS METABOLITE, SALICYLIC ACID, ON CULTURED RAT EMBRYO
- ACETYLSALICYLIC ACID INDUCED FETALTOXICITY AND DRUG METABOLISM
- POTENTIATION OF EPN-INDUCED INHIBITION OF LIVER MICROSOMAL CARBOXYLESTERASE BY NAD IN VITRO
- Immune response to a laminin-binding protein (Lmb) in group A streptococcal infection
- STIMULATORY EFFECT OF CYANIDE ON ANILINE p-HYDROXYLATION IN RAT LIVER MICROSOMES
- Early neonatal onset carbamoyl-phosphate synthase 1 deficiency treated with continuous hemodiafiltration and early living-related liver transplantation
- PHYSIOLOGICAL ROLES OF ALDO/KETO REDUCTASES IN REPRODUCTIVE ORGANS
- LOCALIZATION OF CARBONYL REDUCTASE IN RAT OVARY AND ITS PHYSIOLOGICAL ROLE IN OVARIAN FUNCTION
- CHARACTERISTIC AND PHYSIOLOGICAL ROLES OF CARBONYL REDUCTASES IN RAT OVARY
- CHARACTERISTICS OF 13,14-DIHYDROPROSTAGLANDIN F_ SYNTHETASE OF RAT OVARY
- A possible mechanism of neonatal intrahepatic cholestasis caused by citrin deficiency
- ASSESSMENT OF TRANSENDOSCOPIC MINIATURE ULTRASONIC PROBE FOR CHEMORADIOTHERAPY OUTCOME IN PATIENTS WITH LOCALLY ADVANCED ESOPHAGEAL CANCER
- EFFECTS OF DIIOSPROPYL-1, 3-DITHIOL-2-YLIDENE MALONATE (NKK-105) ON ACUTE TOXICITY OF VARIOUS DRUGS AND HEAVY METALS.
- A pregnant patient with fulminant hepatic failure was found to carry a novel missense mutation in the argininosuccinate synthetase gene
- Distribution and Co-Localization of Nitric Oxide Synthase and Argininosuccinate Synthetase in the Cat Hypothalamus
- MRI of adult-onset type II citrullinemia
- Enzymatic corrections for cells derived from Fabry disease patients by a recombinant adenovirus vector
- Lethal and Dermonecrotic Activities of Clostridium perfringens lota Toxin: Biological Activities Induced by Cooperation of Two Nonlinked Components
- A Case of Cystoid Macular Edema Associated with Latanoprost Ophthalmic Solution
- MECHANISM OF ANTI-PLATELET AGGREGATING ACTION OF DILAZEP
- A Study of γ-Aminobutyric Acid (GABA) in Amniotic Fluid
- REGULATION AND PHYSIOLOGICAL ROLE OF HEPATIC MICROSOMAL CARBOXYLESTERASES
- Histological findings in the livers of patients with neonatal intrahepatic cholestasis caused by citrin deficiency
- EFFECT OF LIPID PEROXIDATION ON COVALENT BINDING OF ACTIVE METABOLITE OF ACETAMINOPHEN TO LIVER MICROSOMAL MACROMOLECULES IN SEVERAL ANIMAL SPECIES
- PROTECTIVE ROLE OF COMPONENTS IN CELL CYTOSOL AGAINST ACETAMINOPHEN-INDUCED HEPATOTOXICITY (The Fourth Meeting for the Study of Toxic Effect)
- 118. METABOLISM AND HEPATOTOXICITY OF ACETAMINOPHEN (The Third Meeting for the Study of Toxic Effect)
- Mitochondrial aspartate glutamate carrier (citrin) deficiency as the cause of adult-onset type II citrullinemia (CTLN2) and idiopathic neonatal hepatitis (NICCD)
- Effectiveness of carbohydrate-restricted diet and arginine granules therapy for adult-onset type II citrullinemia : a case report of siblings showing homozygous SLC25A13 mutation with and without the disease
- Attenuation of Cardiac Hypertrophy in Carnitine-Deficient Juvenile Visceral Steatosis (JVS) Mice Achieved by Lowering Dietary Lipid
- COMPARISON OF EFFECTS OF ACETAMINOPHEN ON LIVER MICROSOMAL DRUG METABOLISM AND LIPID PEROXIDATION IN RATS AND MICE
- 124. Toxicity of Procaine and Its Brain Concentration (The Second Meeting for the Study of Toxic Effect)
- SIGNIFICANCE OF GONAD AND RENAL PROSTAGLANDIN E_2 IN THE ANTIHYPERTENSIVE EFFECT OF PINDOLOL IN SPONTANEOUSLY HYPERTENSIVE RATS
- MULTIPLICITY AND FUNCTION OF HEPATIC MICROSOMAL CARBOXYLESTERASES IN VARIOUS MAMMALS AND HUMANS
- MULTIPLICITY AND REGULATION OF HEPATIC MICROSOMAL CARBOXYLESTERASE IN RATS
- THE INVOLVEMENT OF CYTOCHROME P-448 AND P-450 IN NADH-DEPENDENT O-DEMETHYLATION OF p-NITROANISOLE IN RAT LIVER MICROSOMES
- ENHANCEMENT IN VIVO OF DRUG OXIDATIONS FOLLOWING ADMINISTRATION OF BENZPHETAMINE, ACETONE, METYRAPONE AND DIMETHYLSULFOXIDE
- ENHANCEMENT OF NADPH-DEPENDENT LIPID PEROXIDATION ACTIVITY BY ETHYLENE-DIAMINETETRAACETIC ACID (EDTA) IN THE PRESENCE OF FERROUS ION IN RABBIT LIVER MICROSOMES
- STIMULATIVE EFFECTS OF CHELATING AGENTS, 2, 2-BIPYRIDINE AND 1, 10-PHENANTHROLINE, ON LIPID PEROXIDATION IN RAT LIVER MICROSOMES
- INDIVIDUAL DIFFERENCES IN THE OCCURRENCE OF A LIPID PEROXIDATION INHIBITOR IN RAT LIVER SOLUBLE FRACTION
- DIFFERENCES IN THE EFFECT OF EPHEDRINE ISOMERS ON BLOOD PRESSURE IN RATS
- METABOLIC STUDIES ON METIAZINIC ACID I ABSORPTION, DISTRIBUTION, EXCRETION AND METABOLISM IN RATS AND RABBITS
- Effect of Celecoxib, a Selective Cyclooxygenase-2 Inhibitor on Carbon Tetrachloride Intoxication in Rats
- EFFECT OF N-FORMYL-L-METHIONYL-L-LEUCYL-L-PHENYLALANINE AND ITS ANALOGUES ON BLOOD PRESSURE
- INFLUENCE OF MATERNAL DRUG METABOLISM ON THE FETAL TOXICITY INDUCED BY ACETYLSALICYLIC ACID
- Assessment of the lingual tonsil and vallecula during fiberoptic intubation
- Flumazenil reduces the hypnotic dose of propofol in male patients under spinal anesthesia
- Halothane anesthesia decreases the extracellular level of dopamine in rat striatum : a microdialysis study in vivo
- Accidental subdural catheterization suspected on administration of a test dose of lidocaine and successfully managed by a small dose of dibucaine
- NAD-Coupled Enzymatic Oxidation of O-Ethyl O-p-Nitrophenyl Phenylphosphonothioate (EPN) to Its Oxygen Analog with Liver Microsomes of Rats
- Terminal deletion of chromosome 10q : Clinical features and literature review
- Propofol injection pain is not alleviated by pretreatment with flurbiprofen axetil, a prodrug of a nonsteroidal antiinflammatory drug
- MULTIPLICITY AND DIFFERENCES IN THE INDUCTION OF HEPATIC MICROSOMAL CARBOXYLESTERASE ISOZYMES IN INBRED STRAINS OF RATS AND MICE
- The Characteristics of Food Intake in Patients with Type II Citrullinemia
- EFFECTS OF VARIOUS COMPOUNDS ON LIPID PEROXIDATION MEDIATED BY DETERGENT-SOLUBILIZED RAT LIVER NADPH-CYTOCHROME C REDUCTASE
- LIPID PEROXIDATION ACTIVITY MEDIATED BY NADPH-CYTOCHROME C REDUCTASE PURIFIED FROM RABBIT LIVER MICROSOMES
- The mutation spectrum of the SLC25A13 gene in Chinese infants with intrahepatic cholestasis and aminoacidemia
- EFFECTS OF LYOPHILIZATION AND STORAGE OF RAT LIVER MICROSOMES ON ACTIVITY OF ANILINE HYDROXYLASE, CONTENTS OF CYTOCHROME b5 AND CYTOCHROME P-450 AND ANILINE-INDUCED P-450 DIFFERENCE SPECTRUM
- Autoantibodies against C-reactive protein (CRP) in sera of patients with systemic rheumatic diseases
- STUDIES ON THE ULTRASTRUCTURAL DISTRIBUTION OF H3-DIMETACRINE IN RAT CEREBRAL CORTEX
- PARTIAL PURIFICATION AND IMMUNOLOGICAL ASPECTS OF CARBOXYLESTERASE FROM RAT LIVER MICROSOMES
- GLUTATHIONE DEPLETION BY ANILINE ANALOGS IN VITRO ASSOCIATED WITH LIVER MICROSOMAL CYTOCHROME P-450
- EFFECT OF LYOPHILIZATION AND STORAGE OF LIVER 9, 000 × g SUPERNATANT FRACTION ON THE METABOLISM OF IMIPRAMINE IN SEVERAL SPECIES OF ANIMALS
- THE PHARMACOKINETICS OF OCHRATOXIN A IN RATS
- EFFECT OF PRETREATMENT WITH TRICRESYLPHOSPHATES AND PHENOBARBITAL ON THE METABOLISM AND TOXICITY OF PROCAINE IN RATS
- Comparison of Vasodilation Potency between Sufentanil and Fentanyl on the Isolated Aorta of the Rat
- The Role of Kupffer Cells in Carbon Tetrachloride Intoxication in Mice
- Stimulation of microsomal drug oxidation activities by incorporation into microsomes of purified NADPH-cytochrome c (P-450) reductase.
- Inhibition by cyanide of drug oxidations in rat liver microsomes.
- Cause of decrease of ethylmorphine N-demethylase activity by lipid peroxidation in microsomes from the rat, guinea pig and rabbit.
- COMPARISON OF N-OXIDATION AND N-DEMETHYLATION OF DIMETHYLANILINE IN HUMAN LIVER
- Mechanistic Insight into Pentatricopeptide Repeat Proteins as Sequence-Specific RNA-Binding Proteins for Organellar RNAs in Plants
- Neonatal intrahepatic cholestasis caused by citrin deficiency : efficacy of therapeutic formulas and update of clinical outcomes
- Increase in Secretory Sphingomyelinase Activity and Specific Ceramides in the Aorta of Apolipoprotein E Knockout Mice during Aging
- Plasma glutathione S-transferase in carbon tetrachrolide treated rats and its association to hepatic cytosolic isozymes.
- Enhancement of the binding of O-ethyl O-p-nitrophenyl phenylphosphonate (EPNoxon) to microsomal carboxylesterase by NAD in vitro.
- Contribution of isosorbide-5-mononitrate, a major metabolite of isosorbide dinitrate (ISDN), to the hemodynamic effect of ISDN administered orally in conscious dogs.
- Effects of Ca ion and ADP on superprecipitation of myosin B from slime mold, Physarum polycephalum.
- Effects of co-administration of monomethylaminoantipyrine and cobaltous chloride on hepatic glutathione level and glutathione-related enzyme activities in rats.
- Suppression of pentylenetetrazol-induced seizures by hydralazine associated with 5-hydroxytryptaminergic system in rat brain.
- Individual Expression of Candida tropicalis Peroxisomal and Mitochondrial Carnitine Acetyltransferase-Encoding Genes and Subcellular Localization of the Products in Saccharomyces cerevisiae.
- Identification of 13 novel mutations including a retrotransposal insertion in SLC25A13 gene and frequency of 30 mutations found in patients with citrin deficiency