Effect of Celecoxib, a Selective Cyclooxygenase-2 Inhibitor on Carbon Tetrachloride Intoxication in Rats

スポンサーリンク

概要

• 論文の詳細を見る

• CCl4 (0.5 ml/kg as CCl4) was orally administered to rats. Twelve hours after administration of CCl4, plasma alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, indicators of liver necrosis, were significantly higher than those in the control group showing that active liver necrosis took place. At the same time the level of liver vitamin C was decreased significantly compared to that in the control group. Oral administration of 100 mg/kg each of celecoxib 3 and 8 h after CCl4 treatment did not change plasma ALT and AST and liver vitamin C levels 12 h after CCl4 treatment, but 24 h after CCl4 treatment, significantly decreased plasma ALT and AST levels and elevated liver vitamin C level. These finding suggested that celecoxib effectively ameliorated the necrotic action and the oxidative stress induced by CCl4 in the second phase. Although the plasma levels of all ceramide species were significantly increased 24 h after CCl4 intoxication, treatment with celecoxib significantly reduced the total ceramide concentration in plasma. These results indicated that celecoxib significantly ameliorated the toxicity of CCl4 in the second phase.

• 公益社団法人　日本薬学会の論文

著者

• KOBAYASHI Keiko

  Department of Geriatric and Environmental Dermatology, Nagoya City University Graduate School of Med

• KOGA Eriko

  Department of Food Science and Nutrition, Nara Women's University

• WASHINO Yukiko

  Department of Food Science and Nutrition, Nara Women's University

• ICHI Ikuyo

  Department of Food Science and Nutrition, Nara Women's University

• KOJO Shosuke

  Department of Food Science and Nutrition, Nara Women's University

• KITAMURA YUKO

  Department of Internal Medicine, Keio University School of Medicine

• Kojo Shosuke

  Department Of Food Science & Nutrition Nara Women's University

• Kobayashi Keiko

  Department Of Biochemical Pharmacology Faculty Of Pharmaceutical Sciences Chiba University

• Washino Yukiko

  Department Of Food Science And Nutrition Nara Women's University

• NAKAZAKI Chihiro

  Department of Food Science and Nutrition, Nara Women's University

• Kamikawa Chiaki

  Department of Food Science and Nutrition, Nara Womens University

• Nakagawa Tomoka

  Department of Food Science and Nutrition, Nara Womens University

• Kitamura Yuko

  Department Of Food Science And Nutrition Nara Women's University

• Koga Eriko

  Department Of Food Science And Nutrition Nara Women's University

• Ichi Ikuyo

  Department Of Food Science And Nutrition Nara Women's University

• Nakazaki Chihiro

  Department Of Food Science And Nutrition Nara Women's University

• Washino Yukiko

  Department of Food Science and Nutrition, Nara Women's University

• Kamikawa Chiaki

  Department of Food Science and Nutrition, Nara Women's University

• Nakagawa Tomoka

  Department of Food Science and Nutrition, Nara Women's University

• Kobayashi Keiko

  Department of Food Science and Nutrition, Nara Women's University

関連論文

• Effect of Nobiletin on Lipid Metabolism in Rats
• Successful treatment with topical tacrolimus in four cases of discoid lupus erythematosus
• Analyses of the transglutaminase 1 gene mutation and ultrastructural characteristics in a Japanese patient with lamellar ichthyosis
• Caldecrin Is a Novel-Type Serine Protease Expressed in Pancreas, but Its Homologue, Elastase IV, Is and Artifact during Cloning Derived from Caldecrin Gene^1
• Fasting-induced reduction in locomotor activity and reduced response of orexin neurons in carnitine-deficient mice
• Conventional Diet Therapy for Hyperammonemia is Risky in the Treatment of Hepatic Encephalopathy Associated with Citrin Deficiency
• Metabolic derangements in deficiency of citrin, a liver-type mitochondrial aspartate-glutamate carrier
• Risk of Worsened Encephalopathy after Intravenous Glycerol Therapy in Patients with Adult-onset Type II Citrullinemia (CTLN2)
• Hepatocellular Carcinoma in a Case of Adult-onset Type II Citrullinemia
• Expression and Subcellular Localization of Candida tropicalis Catalase in Catalase Gene Disruptants of Saccharomyces cerevisiae
• Individual Expression of Candida tropicalis Peroxisomal and Mitochondrial Carnitine Acetyltransferase-Encoding Genes and Subcellular Localization of the Products in Saccharomyces cerevisiae
• P-137 Cyclohaliclonamines and Phormidinines, Novel 3-Alkylpyridinium and 2-Alkylpyridine Alkaloids from Marine Organisms
• Spongiacysteine, a Novel Cysteine Derivative from Marine Sponge Spongia sp
• Inhibitory Effect of Dimethyl Sulfoxide (DMSO) on Necrosis and Oxidative Stress Caused by D-Galactosamine in the Rat Liver
• Increase of Ceramide in the Liver and Plasma after Carbon Tetrachloride Intoxication in the Rat
• Increased Caspase Activity in Circulating Blood from Patients with Acute Myocardial Infarction
• Antibodies to the 37,000-Mr Tryptic Fragment of Islet Antigen were Detected in Japanese Insulin-Dependent Diabetes Mellitus Patients
• Immune response to a laminin-binding protein (Lmb) in group A streptococcal infection
• Hyperglycemia Decreases Dehydroepiandrosterone in Japanese Male with Impaired Glucose Tolerance and Low Insulin Response
• Early neonatal onset carbamoyl-phosphate synthase 1 deficiency treated with continuous hemodiafiltration and early living-related liver transplantation
• A possible mechanism of neonatal intrahepatic cholestasis caused by citrin deficiency
• ASSESSMENT OF TRANSENDOSCOPIC MINIATURE ULTRASONIC PROBE FOR CHEMORADIOTHERAPY OUTCOME IN PATIENTS WITH LOCALLY ADVANCED ESOPHAGEAL CANCER
• A pregnant patient with fulminant hepatic failure was found to carry a novel missense mutation in the argininosuccinate synthetase gene
• Distribution and Co-Localization of Nitric Oxide Synthase and Argininosuccinate Synthetase in the Cat Hypothalamus
• MRI of adult-onset type II citrullinemia
• Enzymatic corrections for cells derived from Fabry disease patients by a recombinant adenovirus vector
• Effects of Seasonings on the Stability of Ascorbic Acid in a Cooking Model System
• Lethal and Dermonecrotic Activities of Clostridium perfringens lota Toxin: Biological Activities Induced by Cooperation of Two Nonlinked Components
• A Case of Cystoid Macular Edema Associated with Latanoprost Ophthalmic Solution
• A Study of γ-Aminobutyric Acid (GABA) in Amniotic Fluid
• Facile Degradation of Apolipoprotein B by Radical Reactions and the Presence of Cleaved Proteins in Serum
• Mechanism for Aerobic Oxidation of 3, 5-Di-tert-butylcatechol to 3, 5-Di-tert-butyl-o-benzoquinone Catalyzed by Di-μ-hydroxo-dicopper(II) Complexes of Peralkylated Ethylelnediamine Ligands
• Histological findings in the livers of patients with neonatal intrahepatic cholestasis caused by citrin deficiency
• EFFECT OF LIPID PEROXIDATION ON COVALENT BINDING OF ACTIVE METABOLITE OF ACETAMINOPHEN TO LIVER MICROSOMAL MACROMOLECULES IN SEVERAL ANIMAL SPECIES
• PROTECTIVE ROLE OF COMPONENTS IN CELL CYTOSOL AGAINST ACETAMINOPHEN-INDUCED HEPATOTOXICITY (The Fourth Meeting for the Study of Toxic Effect)
• 118. METABOLISM AND HEPATOTOXICITY OF ACETAMINOPHEN (The Third Meeting for the Study of Toxic Effect)
• Mitochondrial aspartate glutamate carrier (citrin) deficiency as the cause of adult-onset type II citrullinemia (CTLN2) and idiopathic neonatal hepatitis (NICCD)
• Increase of Lipid Hydroperoxides in the Rat Liver and Kidney after Administering Ferric Nitrilotriacetate
• Effectiveness of carbohydrate-restricted diet and arginine granules therapy for adult-onset type II citrullinemia : a case report of siblings showing homozygous SLC25A13 mutation with and without the disease
• Attenuation of Cardiac Hypertrophy in Carnitine-Deficient Juvenile Visceral Steatosis (JVS) Mice Achieved by Lowering Dietary Lipid
• A Novel Vitamin C Analog, 2-O-(β-D-Glucopyranosyl) Ascorbic Acid : Examination of Enzymatic Synthesis and Biological Activity(Brewing and Food Technology)
• Change in the Concentration of Vitamins C and E in Rat Tissues by Paraquat Administration(Food & Nutrition Science)
• MECHANISM OF THE ORIGIN OF L-AMINO ACIDS IN THE BIOSPHERE BASED ON EXPERIMENTAL EVIDENCES(Chiral Homogeneity and D-Amino Acids, International Symposium on Origins of Life and Astrobiology)
• Oxidative Stress in the Ischemic and Non-Ischemic Parts of the Rat Liver after Two-Thirds Ischemia/Reperfusion
• Effect of Celecoxib, a Selective Cyclooxygenase-2 Inhibitor on Carbon Tetrachloride Intoxication in Rats
• Changes in the Level of Sialic Acid in Plasma, Brain and Liver of Inherently Scorbutic Rats during Vitamin C and E Deficiencies
• The Antioxidant Role of a Reagent, 2',7'-Dichlorodihydrofluorescin Diacetate, Detecting Reactive-Oxygen Species and Blocking the Induction of Heme Oxygenase-1 and Preventing Cytotoxicity
• The Characteristics of Food Intake in Patients with Type II Citrullinemia
• The mutation spectrum of the SLC25A13 gene in Chinese infants with intrahepatic cholestasis and aminoacidemia
• GLUTATHIONE DEPLETION BY ANILINE ANALOGS IN VITRO ASSOCIATED WITH LIVER MICROSOMAL CYTOCHROME P-450
• The Role of Kupffer Cells in Carbon Tetrachloride Intoxication in Mice
• Mechanistic Insight into Pentatricopeptide Repeat Proteins as Sequence-Specific RNA-Binding Proteins for Organellar RNAs in Plants
• Neonatal intrahepatic cholestasis caused by citrin deficiency : efficacy of therapeutic formulas and update of clinical outcomes
• Increase in Secretory Sphingomyelinase Activity and Specific Ceramides in the Aorta of Apolipoprotein E Knockout Mice during Aging
• Effects of Ca ion and ADP on superprecipitation of myosin B from slime mold, Physarum polycephalum.
• Individual Expression of Candida tropicalis Peroxisomal and Mitochondrial Carnitine Acetyltransferase-Encoding Genes and Subcellular Localization of the Products in Saccharomyces cerevisiae.
• Identification of 13 novel mutations including a retrotransposal insertion in SLC25A13 gene and frequency of 30 mutations found in patients with citrin deficiency

もっと見る 閉じる

スポンサーリンク