Effect of Nobiletin on Lipid Metabolism in Rats
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概要
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Nobiletin enhances differentiation and lipolysis of 3T3-L1 adipocytes and improves hyperglycemia and insulin resistance in obese (ob) diabetic ob/ob mice. We investigated the effects of nobiletin on lipid metabolism and accumulation of body fat in rats. The control group was fed a 20% high-fat diet and 1% cholesterol, and the nobiletin group was fed same diet supplemented with 0.1% (w/w) nobiletin. The rats were fed for 4 weeks. Weights of epididymal, perirenal, total white adipose tissues (WAT: mesenteric, perirenal, and epididymal), and the subcutaneous WAT in the nobiletin group were significantly lower than those in the control group. This decrease was brought about by nobiletin without affecting triglyceride (TG) levels in the liver and skeletal muscle. Plasma TG levels tended to be decreased by nobiletin. The size and diameter of WAT adipocytes in the nobiletin group were significantly lower than those in the control group. This decrease may be partly due to lower lipoprotein lipase (a major determinant for the development of obesity) levels in WAT of the nobiletin group than that of the control group. Plasma levels of high density lipoprotein cholesterol and apolipoprotein A-I increased significantly with administration of nobiletin. These results suggested a beneficial effect of nobiletin on lipid metabolism. However, no significant differences were observed between the nobiletin and the control groups in proteins such as ATP-binding cassette transporter A1, and sterol regulatory element-binding protein-1 in the liver, PPARγ and tumor necrosis factor-α (TNF-α) in WAT, and adiponectin and TNF-α in plasma.
著者
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Ichi Ikuyo
Dep. Of Food Sci. And Nutrition Nara Women's Univ.
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Kojo Shosuke
Department Of Food Science & Nutrition Nara Women's University
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Adachi Noriko
Department Of Chemistry Kyoto University Of Education
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Kitamura Yuko
Department Of Food Science And Nutrition Nara Women's University
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Ichi Ikuyo
Department Of Food Science And Nutrition Nara Women's University
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Nagata Eri
Department of Food Science and Nutrition, Nara Womens University
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Kataoka Ryoko
Department of Food Science and Nutrition, Nara Womens University
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Matsushima Miyuki
Department of Food Science and Nutrition, Nara Womens University
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Sasaki Takao
Arkray Inc.
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Adachi Noriko
Department of Food Science and Nutrition, Nara Women's University
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Ichi Ikuyo
Department of Food Science and Nutrition, Nara Women's University
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Matsushima Miyuki
Department of Food Science and Nutrition, Nara Women's University
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Nagata Eri
Department of Food Science and Nutrition, Nara Women's University
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Kataoka Ryoko
Department of Food Science and Nutrition, Nara Women's University
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