Increase in Secretory Sphingomyelinase Activity and Specific Ceramides in the Aorta of Apolipoprotein E Knockout Mice during Aging
スポンサーリンク
概要
- 論文の詳細を見る
Atherosclerosis is caused by many factors, one of which is oxidative stress. We recently demonstrated that systemic oxidative stress increased secretory sphingomyelinase (sSMase) activity and generated ceramides in the plasma of diabetic rats. In addition, we also showed that the total ceramide level in human plasma correlated with the level of oxidized low-density lipoprotein. To investigate the relationship between ceramide species and atherogenesis during aging, we compared age-related changes in ceramide metabolism in apolipoprotein E knock out mice (apoE−/−) and wild type mice (WT). Although the total plasma ceramide level was higher in apoE−/− than that in WT at all ages, it decreased with increasing age. sSMase activity increased at 65 weeks (w) of age in both strains of mice. When apoE−/− developed atherosclerosis at 15 w of age, C18:0, C22:0, and C24:0 ceramide levels in the apoE−/− aorta significantly increased. Furthermore, at 65 w of age C16:0 and C24:1 ceramide levels were significantly higher than those in WT. These results suggested that elevation in levels of specific ceramide species due to sSMase activity contributed to atherogenesis during aging.
著者
-
Harada-shiba Mariko
Department Of Bioscience National Cardiovascular Center Research Institute
-
Kobayashi Keiko
Department Of Biochemical Pharmacology Faculty Of Pharmaceutical Sciences Chiba University
-
Kikuzaki Hiroe
Department Of Food And Human Health Sciences Graduate School Of Human Life Science Osaka City Univer
-
Sasaki Kazuki
Department Of Molecular Pharmacology National Cerebral And Cardiovascular Center Research Institute
-
Kojo Shosuke
The Open Univ. Of Japan
-
Nagata Eri
Department of Food Science and Nutrition, Nara Women's University
-
Kojo Shosuke
The Open University of Japan
-
Harada-Shiba Mariko
Department of Molecular Innovation in Lipidology, National Cerebral and Cardiovascular Center Research Institute
-
Sasaki Kazuki
Department of Food Science and Nutrition, Nara Women's University
-
Sasaki Kazuki
Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Japan
-
Kikuzaki Hiroe
Department of Food Science and Nutrition, Nara Women's University
関連論文
- OJ-011 Association of Obesity Related Factors with Plasma B-type Natriuretic Peptide Levels in General Japanese Population(OJ02,Obesity/SAS (H),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- FRS-076 A link between LDL Receptor (LDLR) Gene Mutation and Clinical Manifestations in Familial Hypercholesterolemia(FRS16,Basic Mechanisms of Lipid Disorders and Metabolic Syndrome (H),Featured Research Session (English),The 73rd Annual Scientific Meeti
- PJ-898 Predicting high risk patients of coronary artery disease in heterozygous familial hypercholesterolemia from clinical features(Lipid disorders(05)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-897 A Discontinuation of LDL-apheresis Deteriorates Prognosis of Heterozygous Familial Hypercholesterolemia(FH)(Lipid disorders(05)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-089 Has statin delayed the first event of coronary artery disease in heterozyhous familial hypercholesterolemia(FH)?(Lipid disorders(02)(H),Oral Presentation(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- Effect of Nobiletin on Lipid Metabolism in Rats
- Successful treatment with topical tacrolimus in four cases of discoid lupus erythematosus
- OJ-061 Association analysis between autosomal recessive hypercholesterolemia (ARH) gene and hypercholesterolemia(Lipid Disorders 1 (H) : OJ8)(Oral Presentation (Japanese))
- Analyses of the transglutaminase 1 gene mutation and ultrastructural characteristics in a Japanese patient with lamellar ichthyosis
- Caldecrin Is a Novel-Type Serine Protease Expressed in Pancreas, but Its Homologue, Elastase IV, Is and Artifact during Cloning Derived from Caldecrin Gene^1
- Fasting-induced reduction in locomotor activity and reduced response of orexin neurons in carnitine-deficient mice
- Conventional Diet Therapy for Hyperammonemia is Risky in the Treatment of Hepatic Encephalopathy Associated with Citrin Deficiency
- Metabolic derangements in deficiency of citrin, a liver-type mitochondrial aspartate-glutamate carrier
- Risk of Worsened Encephalopathy after Intravenous Glycerol Therapy in Patients with Adult-onset Type II Citrullinemia (CTLN2)
- Hepatocellular Carcinoma in a Case of Adult-onset Type II Citrullinemia
- Expression and Subcellular Localization of Candida tropicalis Catalase in Catalase Gene Disruptants of Saccharomyces cerevisiae
- Individual Expression of Candida tropicalis Peroxisomal and Mitochondrial Carnitine Acetyltransferase-Encoding Genes and Subcellular Localization of the Products in Saccharomyces cerevisiae
- P-137 Cyclohaliclonamines and Phormidinines, Novel 3-Alkylpyridinium and 2-Alkylpyridine Alkaloids from Marine Organisms
- Spongiacysteine, a Novel Cysteine Derivative from Marine Sponge Spongia sp
- Inhibitory Effect of Dimethyl Sulfoxide (DMSO) on Necrosis and Oxidative Stress Caused by D-Galactosamine in the Rat Liver
- PJ-378 Decreased Circulating CD34-positive Cells are Associated with High Plasma BNP Concentration in Elderly Patients with Type 2 Diabetes Mellitus(Diabetes/Obesity/Metabolic syndrome-9 (H) PJ64,Poster Session (Japanese),The 70th Anniversary Annual Scien
- Obesity and Insulin Resistance Possibly Promotes Ischemic Heart Disease of the Patients with Familial Combined Hyperlipidemia (FCHL)(Lipid Disorders 4 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Isocaloric High-protein Diet Ameliorates Systolic Blood Pressure Increase and Cardiac Remodeling Caused by Maternal Caloric Restriction in Adult Mouse Offspring
- Transgenic Approach toward Leptin Biology : The Clinical Implications of Leptin for the Treatment of Obesity-Associated Diabetes and Obesity-Related Hypertension
- Immune response to a laminin-binding protein (Lmb) in group A streptococcal infection
- LOW DENSITY LIPOPROTEIN (LDL) BINDING AFFINITY TO LDL RECEPTOR IN HYPERLIPOPROTEINEMIA
- Early neonatal onset carbamoyl-phosphate synthase 1 deficiency treated with continuous hemodiafiltration and early living-related liver transplantation
- IS055 Leptin, a Missing Link Between Obesity and Hypertension
- IS-33 Effects of hyperleptinemia on food intake and blood pressure in transgenic mice overexpressing leptin during pregnancy
- A possible mechanism of neonatal intrahepatic cholestasis caused by citrin deficiency
- Identification of Novel Neuroendocrine Regulatory Peptide 1 and 2 by Peptidome Analysis Strategy
- ASSESSMENT OF TRANSENDOSCOPIC MINIATURE ULTRASONIC PROBE FOR CHEMORADIOTHERAPY OUTCOME IN PATIENTS WITH LOCALLY ADVANCED ESOPHAGEAL CANCER
- A pregnant patient with fulminant hepatic failure was found to carry a novel missense mutation in the argininosuccinate synthetase gene
- Distribution and Co-Localization of Nitric Oxide Synthase and Argininosuccinate Synthetase in the Cat Hypothalamus
- MRI of adult-onset type II citrullinemia
- Enzymatic corrections for cells derived from Fabry disease patients by a recombinant adenovirus vector
- Lethal and Dermonecrotic Activities of Clostridium perfringens lota Toxin: Biological Activities Induced by Cooperation of Two Nonlinked Components
- A Case of Cystoid Macular Edema Associated with Latanoprost Ophthalmic Solution
- Spasmolytic Activity of Aurapten Analogs
- A Study of γ-Aminobutyric Acid (GABA) in Amniotic Fluid
- Histological findings in the livers of patients with neonatal intrahepatic cholestasis caused by citrin deficiency
- EFFECT OF LIPID PEROXIDATION ON COVALENT BINDING OF ACTIVE METABOLITE OF ACETAMINOPHEN TO LIVER MICROSOMAL MACROMOLECULES IN SEVERAL ANIMAL SPECIES
- PROTECTIVE ROLE OF COMPONENTS IN CELL CYTOSOL AGAINST ACETAMINOPHEN-INDUCED HEPATOTOXICITY (The Fourth Meeting for the Study of Toxic Effect)
- 118. METABOLISM AND HEPATOTOXICITY OF ACETAMINOPHEN (The Third Meeting for the Study of Toxic Effect)
- Mitochondrial aspartate glutamate carrier (citrin) deficiency as the cause of adult-onset type II citrullinemia (CTLN2) and idiopathic neonatal hepatitis (NICCD)
- Effectiveness of carbohydrate-restricted diet and arginine granules therapy for adult-onset type II citrullinemia : a case report of siblings showing homozygous SLC25A13 mutation with and without the disease
- Attenuation of Cardiac Hypertrophy in Carnitine-Deficient Juvenile Visceral Steatosis (JVS) Mice Achieved by Lowering Dietary Lipid
- Change in the Concentration of Vitamins C and E in Rat Tissues by Paraquat Administration(Food & Nutrition Science)
- Oxidative Stress in the Ischemic and Non-Ischemic Parts of the Rat Liver after Two-Thirds Ischemia/Reperfusion
- Effect of Celecoxib, a Selective Cyclooxygenase-2 Inhibitor on Carbon Tetrachloride Intoxication in Rats
- Transformation of Glycyrrhizic Acid by Aspergillus spp.
- New Bitter Diterpenes, Rabdosianone I and II, Isolated from Isodon japonicus Hara
- The Characteristics of Food Intake in Patients with Type II Citrullinemia
- Chemical Constituents of Cape Aloe and Their Synergistic Growth-Inhibiting Effect on Ehrlich Ascites Tumor Cells
- A novel hypothalamic peptide, neuroendocrine regulatory peptide-2, regulates feeding behavior via the orexin system in the hypothalamus
- The mutation spectrum of the SLC25A13 gene in Chinese infants with intrahepatic cholestasis and aminoacidemia
- LC-MS Analysis and Structural Determination of New Amides from Javanese Long Pepper (Piper retrofractum)
- Microbial Transformation of (±)-Epoxyaurpten by Pseudomonas aeruginosa
- Proteolytic processing of neurosecretory protein VGF in the rat
- Peptidomics-based discovery of bioactive peptides
- Global Identification of Peptide Processing Sites Implicated in the Regulated Secretory Pathway
- GLUTATHIONE DEPLETION BY ANILINE ANALOGS IN VITRO ASSOCIATED WITH LIVER MICROSOMAL CYTOCHROME P-450
- Association of plasma B-type natriuretic peptide levels with obesity in a general urban Japanese population : the Suita study
- A Case of Thyroid Storm with Multiple Organ Failure Effectively Treated with Plasma Exchange
- Peptidomics-Based Discovery of AMP-IBP5, an Antimicrobial Peptide Derived from Insulin-Like Growth Factor-Binding Protein 5
- The Role of Kupffer Cells in Carbon Tetrachloride Intoxication in Mice
- Mechanistic Insight into Pentatricopeptide Repeat Proteins as Sequence-Specific RNA-Binding Proteins for Organellar RNAs in Plants
- Neonatal intrahepatic cholestasis caused by citrin deficiency : efficacy of therapeutic formulas and update of clinical outcomes
- Familial Hypercholesterolemia with Multiple Large Tendinous Xanthomas and Advanced Coronary Artery Atherosclerosis
- Increase in Secretory Sphingomyelinase Activity and Specific Ceramides in the Aorta of Apolipoprotein E Knockout Mice during Aging
- A New Antioxidative Glucoside Isolated from Oregano (Origanum vulgare L.)
- Effects of Ca ion and ADP on superprecipitation of myosin B from slime mold, Physarum polycephalum.
- Structure of a New Antioxidative Phenolic Acid from Oregano (Origanum vulgare L.)
- Individual Expression of Candida tropicalis Peroxisomal and Mitochondrial Carnitine Acetyltransferase-Encoding Genes and Subcellular Localization of the Products in Saccharomyces cerevisiae.
- Identification of 13 novel mutations including a retrotransposal insertion in SLC25A13 gene and frequency of 30 mutations found in patients with citrin deficiency