THE APPARENT LOSS OF CYTOCHROME P-450 ASSOCIATED WITH METABOLIC ACTIVATION OF CARBON TETRACHLORIDE
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概要
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Carbon monoxide inhibited the carbon tetrachloride-induced NADPH oxidation rate. The addition of methylviologen to the incubation mixture under the atmosphere of nitrogen resulted in the enhancement of the reductase activity of microsomes for carbon tetrachloride, as determined by chloroform formation. The addition of methylviologen also enhanced the carbon tetrachloride-induced loss of cytochrome P-450, while the apparent content of cytochrome b<SUB>5</SUB> and the activity of NADPH-cytochrome <I>c</I> reductase remained unchanged. Under a strong inhibition of lipid peroxidation by addition of EDTA, carbon tetrachloride induced a clear loss of cytochrome P-450 to the extent similar to that seen in the absence of EDTA. These results indicate that cytochrome P-450 is directly degraded in association with the reductive metabolism of carbon tetrachloride by cytochrome P-450.
- 社団法人 日本薬理学会の論文
著者
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YAMAZOE YASUSHI
Department of Pharmacology, School of Medicine, Keio University
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KAMATAKI TETSUYA
Department of Pharmacology, School of Medicine, Keio University
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Yamazoe Yasushi
Department Of Pharmacology School Of Medicine Keio University:department Of Analytical Biochemistry
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Kato Ryuichi
Department Of Biology Graduate School Of Science Osaka University
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Yamazoe Yasushi
Department Of Pharmacology School Of Medicine Keio University
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Kamataki Tetsuya
Department Of Biochemical Pharmacology Faculty Of Pharmaceutical Sciences Chiba University
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Sugiura Masahiko
Department Of Chemical Engineering Waseda University
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KAMATAKI Tetsuya
Department of Analytical Bio chemistry, School of Pharmacy, Hokkaido University
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YAMAZOE Yasushi
Department of Drug Metabolism and Molecular Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University
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