ROLE OF PHOSPHOLIPID IN THE EFFECT OF ESTRADIOL ON SUGAR TRANSPORT IN RAT UTERUS

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In 1961, one of the authors (1) demonstrated that estrogen stimulated the biosynthesis of phospholipids in the ovariectomized rat uterus and phospholipid metabolism constitutes an unusually sensitive indicator of early estrogen action. Recently, Roskoski and Steiner reported that estrogen injection increases the initial rate of 3-0-methylglucose transport into uterine cells and this transport takes place by means of a specific mobile carrier transport system (2).<BR> Phospholipid is an essential component of biological membrane (3, 4) and it has been clarified that phospholipid affects various enzymic reactions (5-10). Membrane lipid is also of interest in this regard as it may play an important role in transport of a substance through cell membrane.<BR> This present report is an investigation as to whether or not sugar transport into uterine cells, which is accelerated by estrogen administration, is affected by phospholipids in vitro. It was observed that sugar transport in the spayed rat uterus increased with the addition of phospholipid.
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