Effect of psychotropic drugs on the contents of melatonin, serotonin and N-acetylserotonin in rat pineal gland.
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概要
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In the dark phase, the effects of the psychotropic drugs on the contents of melatonin, serotonin (5-HT) and N-acetylserotonin (NAS) in rat pineal gland were examined. The pineal gland was removed at a certain period of time after subcutaneous injection of the drugs. 5-HT, NAS and melatonin contents in the pineal gland were determined by high performance liquid chromatography with fluorometric detection. A dose-dependent decrease was observed for melatonin content in the administration of diazepam (DZP), hydroxyzine (HYZ), chlorpromazine (CPZ) or haloperidol (HPD). When imipramine (IPM) or amitriptyline (APL) was given to rats, pineal 5-HT content was significantly decreased. On the other hand, the administration of IPM or APL caused increases in pineal NAS and melatonin. Furthermore, the administration of phenytoin (PYT) revealed no changes in the content of pineal indoleamines. These results suggest that the psychotropic drugs widely used in clinical applications could cause significant changes in pineal indoleamine content.
著者
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Shimada Kenji
Department Of Analytical Chemistry Faculty Of Pharmaceutical Sciences Niigata University Of Pharmacy
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Wakabayashi Hiroyuki
Department Of Analytical Chemistry Niigata College Of Pharmacy
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Wakabayashi Hiroyuki
Department of Analytical Chemistry, Niigata College of Pharmacy
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AIZAWA Yoshio
Department of Pharmacolgy, Tokyo College of Pharmacy
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SHIMADA Kenji
Department of Analytical Chemistry, Niigata College of Pharmacy
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SATOH Tetsuo
Laboratory of Biochemical Pharmacology and Biotoxicology
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Satoh Tetsuo
Laboratory of Biochemical Pharmacology and Biotoxicology, Faculty of Pharmaceutical Sciences, Chiba University
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