EFFECT OF DIISOPROPYL 1,3-DITHIOL-2-YLIDENEMALONATE ON MICROSOMAL ELECTRON TRANSPORT SYSTEM IN RAT LIVER
スポンサーリンク
概要
- 論文の詳細を見る
Effect of diisopropyl 1,3-dithiol-2-ylidenemalonate (NKK-105) on the components of rat liver microsomal electron transport system was investigated by comparison with those of phenobarbital, 3-methylcholanthrene and polychlorinated biphenyl. When NKK-105 was administered to rats at a dose of 250 mg/kg/day for 7 days, cytochrome b_5 content and NADPH-cytochrome c reductase activity were significantly increased but cytochrome P-450 content to the lesser extent. Three inducers of the drug metabolizing enzymes remarkably increased cytochrome P-450 content but increased cytochrome b_5 content to a lesser extent.
- 公益社団法人日本薬学会の論文
著者
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KITAGAWA HARUO
Laboratory of Biochemical Pharmacology and Biotoxicology, Faculty of Pharmaceutical Sciences, Chiba
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SATOH TETSUO
Laboratory of Biochemical Pharmacology and Biotoxicology, Faculty of Pharmaceutical Sciences, Chiba
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Kitada Mitsukazu
Laboratory Of Hospital Pharmacy Faculty Of Pharmaceutical Sciences Chiba University:division Of Anal
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Kitada Mitsukazu
Laboratory Of Biochemical Pharmacology And Biotoxicology Department Of Drug Evaluation And Toxicolog
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Kitagawa Haruo
Laboratory Of Biochemical Pharmacology And Biotoxicology Department Of Drug Evaluation And Toxicolog
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KATOH MINORU
Laboratory of Biochemical Pharmacology and Biotoxicology, Department of Drug Evaluation and Toxicolo
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SUGIMOTO TATSUYOSHI
Biological Research Center, NIHON NOHYAKU Co., Ltd.
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KASAI TSUTOMU
Biological Research Center, NIHON NOHYAKU Co., Ltd.
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Kasai Tsutomu
Biological Research Center Nihon Nohyaku Co. Ltd.
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Katoh Minoru
Laboratory Of Biochemical Pharmacology And Biotoxicology Department Of Drug Evaluation And Toxicolog
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Sugimoto Tatsuyoshi
Biological Research Center Nihon Nohyaku Co. Ltd.
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Satoh Tetsuo
Laboratory Of Biochemical Pharmacology And Biotoxicology Faculty Of Pharmaceutical Sciences Chiba Un
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Kitada Mitsukazu
Laboratory Of Biochemical Pharmacology And Biotoxicology And Hospital Pharmacy:faculty Of Pharmaceut
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Satoh Tetsuo
Laboratory Of Biochemical Pharmacology And Biotoxicology Department Of Drug Evaluation And Toxicolog
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Satoh Tetsuo
Laboratory Of Biochemical Pharmacology And Biotoxicology Department Of Drug Evaluation And Toxicolog
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KITAGAWA Haruo
Laboratory of Biochemical Pharmacology and Biotoxicology
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SATOH Tetsuo
Laboratory of Biochemical Pharmacology and Biotoxicology
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