Analysis of the Blood Level of Micafungin Involving Patients with Hematological Diseases : New Findings Regarding Combination Therapy with Tacrolimus(Pharmacology)
スポンサーリンク
概要
- 論文の詳細を見る
In 29 patients (40 samples) with hematological diseases who had been treated with a candin antifungal agent, micafungin (MCFG), we measured the blood level of MCFG by high-performance liquid chromatography (HPLC). There was a correlation between the dose and the blood level of MCFG (r=0.729, p<0.001). In addition, there was a correlation between the total bilirubin level and the C/D value (r=0.458, p<0.01), which was calculated by dividing the blood level of MCFG by the dose, although there was no correlation between creatinine clearance and the C/D value. These findings suggest that the dose of MCFG must be regulated in patients with biliary stasis-type liver hypofunction. In addition, there was no significant difference in the blood level of MCFG between the group in which tacrolimus (FK506) was combined with MCFG and the group in which MCFG alone was administered. These results suggest that there are no changes in the blood level of MCFG even when MCFG is combined with FK506.
- 公益社団法人日本薬学会の論文
- 2005-03-01
著者
-
Kobayashi Hikaru
Department Of Surgical Oncology Osaka City University Graduate School Of Medicine
-
SHIMADA Kenji
Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences, Niigata University of Pharma
-
OHTA SHIN
Department of Pharmacy, Shinshu University Hospital
-
SAITOU HIROSHI
Department of Third Internal Medicine, Nagano Red Cross Hospital
-
YAMATO Susumu
Department of Analytical Chemistry, Niigata College of Pharmacy
-
KAWANO Kenji
Department of Pharmacy, Niigata University of Pharmacy and Applied Life Sciences
-
Hirabayashi Kazuko
The Second Department Of Internal Medicine Shinshu University School Of Medicine
-
Ohta Shin
Pharmaceutical Health Care And Sciences Tokyo Univ. Of Pharmacy And Life Sci.
-
Ohta Shin
Department Of Hospital Pharmacy Shinshu University School Of Medicine
-
大和 進
Pharmaceutical And Analytical Chemistry Niigata Univ. Of Pharmacy And Applied Life Sciences
-
Shimada Kenji
Department Of Analytical Chemistry Faculty Of Pharmaceutical Sciences Niigata University Of Pharmacy
-
Sasaki Mutsuko
Department Of Clinical Pharmaceutics Niigata University Of Pharmacy And Applied Life Sciences
-
SHIMOEDA Sadahiko
Department of Pharmacy, Nagano Red Cross Hospital
-
KUBOTA Ai
Department of Pharmaceutical and Analytical Chemistry, Niigata University of Pharmacy and Applied Li
-
Saitou Hiroshi
Department Of Physical Therapy Clinical Welfare College
-
Hora Kazuhiko
Department Of Hematology Nagano Red Cross Hospital
-
Kobayashi Hikaru
Department Of Hematology Nagano Red Cross Hospital
-
Kubota Ai
Department Of Pharmaceutical And Analytical Chemistry Niigata University Of Pharmacy And Applied Lif
-
Saitou H
Nagano Red Cross Hospital Nagano Jpn
-
Kawano Kenji
First Internal Medicine Nagano Red Cross Hospital
-
Kawano Kenji
Department Of Oncological Science (oral And Maxillofacial Surgery) Faculty Of Medicine Oita Universi
-
Kodaira H
The Second Department Of Internal Medicine Shinshu University School Of Medicine
-
Kobayashi Hikaru
Department Of Pharmacy Nagano Red Cross Hospital
-
SAITOU Hiroshi
Department of First Internal Medicine, Nagano Red Cross Hospital
-
KAWANO Kenji
Department of Clinical Pharmaceutics, Niigata University of Pharmacy and Applied Life Sciences
-
Yamato Susumu
Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences
-
Ohta Shin
Department of Functional Molecular Chemistry, Kyoto Pharmaceutical University
関連論文
- Sweet Potato Acid Phosphatase Immobilized on Glutaraldehyde-Activated Aminopropyl Controlled-Pore Glass : Activation, Repeated Use and Enzyme Fatigue
- Sweet Potato Acid Phosphatase Immobilized on Glutaraldehyde-Activated Aminopropyl Controlled-Pore Glass : Activation, Repeated Use and Enzyme Fatigue(Miscellameous)
- DNA methyltransferase inhibitor 5-aza-CdR enhances the radiosensitivity of gastric cancer cells
- Primary Leiomyosarcoma of the Breast : Report of a Case
- Rapid Analysis of 4-O-Methylpyridoxine in the Serum of Patients with Ginkgo Biloba Seed Poisoning by Ion-Pair High-Performance Liquid Chromatography (Analytical Biochemistry)
- 14q11 abnormality and trisomy 8q are not common in Japanese T-cell prolymphocytic leukemia
- Clinical Pharmacokinetic Study of Arsenic Trioxide in an Acute Promyelocytic Leukemia (APL) Patient : Speciation of Arsenic Metabolites in Serum and Urine(Pharmacology)
- P6-35 Efficacy and pharmacokinetics of arsenic trioxide for treatment of acute promyelocytic leukemia(APL) : 1. Efficacy for APL of Arsenic trioxide(ATO)(DRUG METABOLISM/CARCINOGENICITY)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annu
- Development of Disinfectant Mats and Evaluation of Their Effectiveness
- Preparation and Characteristics of Antibacterial Sepiolite Containing Povidone-Iodine as a Useful Pharmaceutical Product for Patient Care
- Neuroendocrine Carcinoma of the Sigmoid Colon: Report of a Case
- Drug Compliance in Patients with Bronchial Asthma : Relation among Compliance with Different Types of Antiasthmatic Drug and Association with Daily Administration Frequency
- Analysis of Drug Compliance in Adult Patients with Bronchial Asthma
- PJ-525 The Cardiac Function of CAWS-induced Aortitis in DBA/2 Mouse, As a Model of Heart Failure(Infection/Inflammation/Immunity(03)(I),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- Intestinal Diffuse Large B-Cell Lymphoma Associated with Celiac Disease : A Japanese Case
- Liver cirrhosis with marked thrombocytopenia and highly elevated serum thrombopoietin levels
- Low prevalence of a polymorphism of platelet membrane glycoprotein Ibβ associated with noenatal alloimmune thrombocytopenic purpura in Asian populations
- Interface States at Ultrathin Chemical Oxide/Silicon Interfaces Obtained from Measurements of XPS Spectra under Biases
- Interface States for Si-Based MOS Devices with an Ultrathin Oxide Layer : X-Ray Photoelectron Spectroscopic Measurements under Biases
- In vitro and in vivo evidence that a combination of lapatinib plus S-1 is a promising treatment for pancreatic cancer
- Carcinoid Tumor of the Kidney Presenting as a Large Abdominal Mass : Report of a Case
- Lymphangioma of the Lesser Omentum Associated with Abdominal Esophageal Carcinoma : Report of a Case
- Structural Relaxation of Ultrathin Polymer Films Prepared by the Langmuir-Blodgett Technique.Molecular Weight Effect on the Diffusion of Polymer Segments
- Bladder evisceration in a child with antenatally detected gastroschisis : Outcome of bladder function
- Significance of phospho-vascular endothelial growth factor receptor-2 expression in pancreatic cancer
- High Performance Liquid Chromatographic Determination of Acetoacetate by Post-Column Derivatization with p-Nitrobenzene Diazonium Fluoroborate
- A Comparative Study of Characteristics of Current-Type and Conventional-Type Cationic Bactericides
- Urological emergency in neonates with congenital hydronephrosis
- Tacrolimus Related Brady and Tachyarrhythmias in a Familial Amyloid Polyneuropathy Patient who Underwent Partial Liver Transplantation
- Tacrolimus Related Brady and Tachyarrhythmias in a Familial Amyloid Polyneuropathy Patient who Underwent Partial Liver Transplantation
- An Asian Variant of Intravascular Lymphoma Diagnosed Through Splenectomy
- Prepuce-Sparing hypospadias repair with tubularized incised plate urethroplasty
- Surgical treatment for ureterocele with special reference to lower urinary tract reconstruction
- Reversibility of Ischemic Findings on 3-T T_2^*-Weighted Imaging After Emergency Superficial Temporal Artery-Middle Cerebral Artery Anastomosis in Patients With Progressive Ischemic Stroke : Two Case Reports
- Biochemical Characterization of a Pseudomonas fluorescens Strain Isolated from a Benzalkonium Chloride Solution
- Clinical Significance of Measuring the Blood Concentration of Itraconazole Oral Solution in the Field of Hematology
- Two Different Mechanisms Are Involved in the Extremely High-Level Benzalkonium Chloride Resistance of a Pseudomonas fluorescens Strain
- Gemtuzumab ozogamicin-induced long-term remission in a woman with acute myelomonocytic leukemia and bone marrow relapse following allogeneic transplantation
- Cystadenoma Arising from the Retromolar Region : A Case Report
- Effect of cyclosporin A on patients with lupus nephritis: a review of the literature
- Method for Screening and Quantitative Determination of Serum Levels of Salicylic Acid, Acetaminophen, Theophylline, Phenobarbital, Bromvalerylurea, Pentobarbital, and Amobarbital Using Liquid Chromatography/Electrospray Mass Spectrometry(Analytical Bioche
- Toxicokinetics of DL-Glufosinate Enantiomer in Human BASTAR Poisoning
- Histological study of fetal kidney with urethral obstruction and vesicoureteral reflux : A consideration on the etiology of congenital reflux nephropathy
- Determination of the Antifungal Agent Voriconazole in Human Plasma Using a Simple Column-Switching High-Performance Liquid Chromatography and Its Application to a Pharmacokinetic Study
- Effective Blood Concentration of Micafungin for Pulmonary Aspergillosis(Pharmacology)
- Analysis of the Blood Level of Micafungin Involving Patients with Hematological Diseases : New Findings Regarding Combination Therapy with Tacrolimus(Pharmacology)
- Evidence for the Degradation of Maleate Moiety in Chlorpheniramine Maleate Solution Using a Stability-Indicating HPLC Method
- Fungicidal Activity of New Quaternary Ammonium Salts
- Comparative Fungicidal Activity of a New Quaternary Ammonium Salt, N-Alkyl-N-2-hydroxyethyl-N, N-dimethylammonium Butyl Phosphate and Commonly Used Disinfectants
- Magnetic Order of Cu-Moments in La_Ba_xCuO_4 around x=0.12 Observed by Positive Muon Spin Rotation
- Getting up from a Side-Lying Position at Different Angles of the Shoulder Joint : Electromyography of Muscles Surrounding the Shoulder Joint and Abdominal Muscles
- The Effects of the Chaining Method in Walking with a Simulated Prosthetic Femur on Motion Studies
- Initiation of Enzyme Replacement Therapy for an Adult Patient with Asymptomatic Type 1 Gaucher's Disease
- Assessment of Tear Concentrations on Therapeutic Drug Monitoring. III. Determination of Theophylline in Tears by Gas Chromatography/Mass Spectrometry with Electron Ionization Mode
- Determination of Valproic Acid in Serum by Liquid Chromatography-Atmospheric Pressure Chemical Ionization Mass Spectrometry
- Urinary control after the definitive reconstruction of cloacal anomaly
- Effect of ureteral reimplantation on prevention of urinary tract infection and renal growth in infants with primary vesicoureteral reflux
- Surgical management of urinary incontinence in children with anatomical bladder-outlet anomalies
- Histology of the fetal prune belly syndrome with reference to the efficacy of prenatal decompression
- Lymphadenopathy of IgG4-related sclerosing disease : three case reports and review of literature
- Graft failure in cord blood transplantation successfully treated with short-term reduced-intensity conditioning regimen and second allogeneic transplantation
- Combination effect of a TGF-β receptor kinase inhibitor with 5-FU analog S1 on lymph node metastasis of scirrhous gastric cancer in mice
- Urological management of cloacal anomalies
- Ph^1-Positive Acute Lymphoblastic Leukemia in a Patient with a Germline MEN1 Gene Mutation
- CD56^+ acute myeloid leukemia with monosomy 7
- Treatment of Idiopathic Gustatory Rhinorrhea by Resection of the Posterior Nasal Nerve
- Three-Dimensional Structure of Natural Convection of Water near the Density Extremum within a Horizontal Annulus
- Secondary Squamous Cell Carcinoma of the Oral Cavity in Young Adults after Hematopoietic Stem Cell Transplantation for Leukemia : Report of Two Cases with Human Papillomavirus Infection
- Positioning the instillation of contrast at the ureteral orifice cystography can be useful to predict postoperative contralateral reflux in children with unilateral vesicoureteral reflux
- Retrovesical cystic lesions in female patients with unilateral renal agenesis or dysplasia
- Simultaneous determination of pregnenolone and 17α-hydroxypregnenolone by semi-micro high-performance liquid chromatography with an immobilized cholesterol oxidase as a pre-column reactor : Application to bovine adrenal fasciculata cells
- Inter-twin contact in a case of monochorionic diamniotic twins with acrania of one twin fetus at 10-13 weeks' gestation
- Severe Pulmonary Toxoplasmosis Mimicking Viral Pneumonitis after a Third Allogeneic Stem Cell Transplantation in a Man with Acute Lymphoblastic Leukemia
- Long-term outcome of ovotesticular disorder of sex development : A single center experience
- Effect of psychotropic drugs on the contents of melatonin, serotonin and N-acetylserotonin in rat pineal gland.
- Effect of Polyphenols on Production of Steroid Hormones from Human Adrenocortical NCI-H295R Cells
- Development of Disinfectant Mats and Evaluation of Their Effectiveness.
- Effect of Polyphenols on 3-Hydroxy-3-methylglutaryl-Coenzyme A Lyase Activity in Human Hepatoma HepG2 Cell Extracts
- Asian Variant of Intravascular Lymphoma: Aspects of Diagnosis and the Role of Rituximab
- Acquired Cryptorchidism in a Boy with Disorder of Sex Development
- Editorial Comment to Circumcision related to urinary tract infedtions, sexually transmitted infections, human immunodeficiency virus infections, and penile and cervical cancer