Comparative Fungicidal Activity of a New Quaternary Ammonium Salt, N-Alkyl-N-2-hydroxyethyl-N, N-dimethylammonium Butyl Phosphate and Commonly Used Disinfectants
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概要
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We synthesized a new quaternary ammonium salt, N-alkyl-N-2-hydroxyethyl-N, N-dimethylammonium butyl phosphate (ABP) that does not precipitate in the presence of anionic surfactants by incorporating a paired butyl phosphate anion into cationic surfactants. ABP showed much greater bactericidal activities and antirusting effects than benzalkonium chloride (BAC). In this study, the fungicidal effects of ABP were evaluated in comparison with common disinfectants [BAC, chlorhexidine digluconate (CHX) and alkyldiaminoethylglycine hydrochloride (ADE)]. Fungicidal effects were evaluated in 10 strains of 6 fungal species, namely, 3 Candida albicans, 2 Candida tropicalis, 1 Candida parapsilosis, 1 Aspergillus niger, 2 Aspergillus terreus, and 1 Trichophyton rubrum. ABP and BAC showed the same effects on 2 C. tropicalis and C. parapsilosis, and similar effects on 3 C. albicans, with slight differences among the strains. ABP showed quick fungicidal effects against A. niger and 2 A. terreus of molds in 30 min at 0.1% and in 15 min at 0.2 and 0.4%, but BAC showed slow effects against A. niger at 1h and 2 A. terreus at 30min at 0.2 and 0.4%, respectively. There is one factor which may have caused this difference : the former had a butyl phosphate anion and the latter had a chloride anion as a counter ion. BAC, CHX and ADE needed 24h to cause notable effects on A. niger at 0.1% and 1h at 0.2%. The new synthetic anti-rust ABP is considered to have sufficient fungicidal effects that are comparable to those of BAC, CHX and ADE.
- 公益社団法人日本薬学会の論文
- 1996-02-15
著者
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MAKINO Mitsuko
Department of Chemistry, College of Humanities and Sciences, Nihon University
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NAGAI KATSUHIRO
Department of Pharmacy, Shinshu University Hospital
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ZENDA HIROSHI
Department of Pharmacy, Shinshu University Hospital
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Ohta S
Department Of Functional Molecular Chemistry Kyoto Pharmaceutical University
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Ohta Shin
Pharmaceutical Health Care And Sciences Tokyo Univ. Of Pharmacy And Life Sci.
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Ohta Shin
Department Of Hospital Pharmacy Shinshu University School Of Medicine
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Zenda Hiroshi
Department Of Pharmacokinetics Hoshi University
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Makino M
College Of Pharmacy Nihon University
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Makino Mitsuko
Department Of Chemistry College Of Humanities And Sciences Nihon University
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MAKINO Masahiro
Department of Research and Development, Nicca Chemical Co., Ltd.
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Makino Masahiro
Department Of Research And Development Nicca Chemical Co. Ltd.
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Nakayama K
Department Of Pharmacy Shinshu University Hospital
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Makino Masahiro
Department of Neurology, Japanese Red Cross Kyoto Daini Hospital, Japan
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