Oxyfunctionalization Products of Terpenoids with Dimethyldioxirane and Their Biological Activity
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概要
- 論文の詳細を見る
Oxyfunctionalization of the bioactive terpenoids, ursolic acid acetate (1), oleanolic acid acetate (5), lupeol acetate (12), and kaurenic acid (17), with dimethyldioxirane (DMDO) was investigated. Treatment of the terpenoids with DMDO under mild conditions afforded a variety of oxidation and oxydegradation products to yield naturally occurring and/or novel compounds in one step. After chromatographic separation, the structures of the individual isolated products were determined using spectroscopic methods including several homonuclear (^1H-^1H) and heteronuclear (^1H-^<13>C) shift-correlated 2D-NMR techniques. The inhibitory activity of the terpenoid derivatives against α-glucosidase was investigated and compounds 1, 3, 7, and 9 were found to exhibit potent activity.
- 社団法人日本薬学会の論文
- 2007-02-01
著者
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IIDA Takashi
Departments of Transplantation; School of Medicine, Tokai University
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OGAWA Shoujiro
Department of Chemistry, College of Humanities and Sciences, Nihon University
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MAKINO Mitsuko
Department of Chemistry, College of Humanities and Sciences, Nihon University
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FUJIMOTO Yasuo
Department of General Studies, College of Humanities and Sciences, Nihon University
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Ikeda Noriaki
Department Of Forensic Pathology And Sciences Graduate School Of Medical Sciences Kyushu University
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Iida Takashi
Dep. Of Chemistry Coll. Of Humanities & Sciences Nihon Univ.
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Iida Takashi
Department Of Dermatology Nara Medical University
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Ogawa Shoujiro
Dep. Of Chemistry Coll. Of Humanities & Sciences Nihon Univ.
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FUJIMOTO Yasuo
College of Pharmacy, Nihon University
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HOSOI Keiji
Department of Chemistry, College of Humanities and Sciences, Nihon University
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Hosoi Keiji
Department Of Chemistry College Of Humanities And Sciences Nihon University
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Yoshinori Fujimoto
Department Of Chemistry And Materials Science Tokyo Institute Of Technology
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Ikeda Noriaki
Department Of Chemistry College Of Humanities And Sciences Nihon University
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Makino Mitsuko
Department Of Chemistry College Of Humanities And Sciences Nihon University
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Fujimoto Yasuo
Department Of General Studies College Of Humanities And Sciences Nihon University
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Ogawa Shoujiro
Department Of Chemistry College Of Humanities & Sciences Nihon University
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Iida Takashi
Departmenr Of Neuropathology Neurological Institute Graduate School Of Medical Sciences Kyushu Unive
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Fujimoto Yasuo
Department of General Education, College of Humanities and Sciences, Nihon University
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IKEDA Noriaki
Department of Chemistry and Materials Technology, Kyoto Institute of Technology
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