Chemical Synthesis of (22E)-3α,6α,7α,12α-Tetrahydroxy-5β-chol-22-en-24-oic Acid and Its N-Acylamidated Conjugates with Glycine or Taurine: Precursors of the [22,23-3H] Labelled Tracers
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概要
- 論文の詳細を見る
(22E)-3α,6α,7α,12α-Tetrahydroxy-5β-chol-22-en-24-oic acid and its N-acylamidated conjugates with glycine or taurine were synthesized from cholic acid. The key reactions employed are: 1) degradation of the side chain in intermediary C24 3α,6α,7α,12α-tetrahydroxylated bile acid to the corresponding C22 23,24-dinor-aldehyde, followed by Wittig reaction with methyl (triphenylphosphoranylidene)acetate and 2) N-acylamidation of the unconjugated tetrahydroxy-Δ22-5β-cholenoic acid with glycine (or taurine) in the presence of diethylphosphorocyanide and triethylamine as coupling reagents.
著者
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Kakiyama Genta
Department of Chemistry, College of Humanities & Sciences, Nihon University
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Iida Takashi
Department Of Dermatology Nara Medical University
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Kakiyama Genta
Dep. Of Chemistry Coll. Of Humanities & Sciences Nihon Univ.
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Ogawa Shoujiro
Dep. Of Chemistry Coll. Of Humanities & Sciences Nihon Univ.
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Goto Junichi
Department Of Pharmaceutical Sciences Tohoku University Hospital : Department Of Clinical Pharmacy G
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Shimada Miki
Department Of Clinical Pharmacy Tohoku University Graduate School Of Pharmaceutical Sciences
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Mano Nariyasu
Department Of Clinical Pharmacy Tohoku University Graduate School Of Pharmaceutical Sciences
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Ogawa Shoujiro
Department Of Chemistry College Of Humanities & Sciences Nihon University
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Adachi Yuuki
Department of Chemistry, College of Humanities & Sciences, Nihon University
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Goto Junichi
Department Of Pharmaceutical Sciences Tohoku University Hospital
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Iida Takashi
Departmenr Of Neuropathology Neurological Institute Graduate School Of Medical Sciences Kyushu Unive
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Mano Nariyasu
Department of Pharmaceutical Sciences, Tohoku University Hospital
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Adachi Yuuki
Department of Chemistry, College of Humanities & Sciences, Nihon University
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